Critical Reviews in Environmental Science and Technology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 25
Published: Nov. 20, 2024
Bisphenol
A
(BPA)
is
an
emerging
contaminant
that
disrupts
endocrine
systems
and
poses
significant
risks
to
organisms.
It
increasingly
detected
in
municipal
wastewater
due
its
widespread
use
high
production
volume.
Despite
this,
gaps
remain
understanding
the
sources
of
BPA
wastewater,
effects
on
nitrification
denitrification,
potential
for
co-removal
with
ammonia
or
nitrate
during
biological
nitrogen
removal
processes.
This
review
first
examines
BPA,
primarily
from
industrial
effluents
landfill
leachates,
which
enter
treatment
plants
alongside
domestic
sewage.
Additionally,
it
meticulously
elucidated
influences,
performance,
biotransformation
mechanisms
denitrification
processes,
shedding
light
pathways,
functional
microbes
key
enzymes.
While
there
no
consensus
anoxic
conditions,
aerobic
environments
support
biodegradation
through
various
microorganisms.
Lastly,
microbial
cooperation
enhance
discussed,
focusing
bacterial
mutual
alliances
bacteria-algae
metabolic
interaction
consortiums.
provides
valuable
guidance
synergistic
Foods,
Journal Year:
2025,
Volume and Issue:
14(2), P. 214 - 214
Published: Jan. 12, 2025
Bisphenol
A
(BPA)
and
diisobutyl
(DIBP)
phthalate
are
widely
used
as
typical
plasticizers
in
food
packaging.
Plasticizers
can
be
released
from
polymers,
migrate
into
food,
ingested
by
humans,
leading
to
various
health
problems.
However,
little
research
has
investigated
the
combined
toxicity
of
BPA
DIBP,
particularly
their
intestinal
toxicity.
Our
goal
is
analyse
(50
mg/kg)
DIBP
(500
on
intestines
KM
mice.
Additionally,
we
tried
find
natural
products
that
inhibit
or
prevent
DIBP.
The
results
indicated
combination
exposure
resulted
a
reduction
beneficial
flora,
an
increase
D-Lac
levels
(136
±
14
μmol/L),
permeability,
activation
notch
pathway,
decline
stem
cells
(ISCs)
goblet
cells,
compared
single-exposure
sources.
Nevertheless,
Rubus
chingii
Hu
phenolic
extract
(RHPE)
(200,
400
600
ameliorated
DIBP-induced
microbiota
disruption
mucosal
barrier
impairment
inhibiting
overactivation
pathway.
this
study
highlight
potential
risks
human
posed
may
help
explain
pathways
enterotoxicity
caused
ingestion.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(47), P. 35128 - 35162
Published: Jan. 1, 2024
Bisphenol
A
(BPA)
raises
concerns
among
the
scientific
community
as
it
is
one
of
most
widely
used
compounds
in
industrial
processes
and
a
component
polycarbonate
plastics
epoxy
resins.
In
this
review,
we
discuss
mechanism
BPA
toxicity
food-grade
plastics.
Owing
to
its
proliferation
aqueous
environment,
delved
into
performance
various
biological,
physical,
chemical
techniques
for
remediation.
Detailed
mechanistic
insights
these
removal
are
provided.
The
toxic
effects
unravel
changes
at
cellular
level
brain,
which
can
result
learning
difficulties,
increased
aggressiveness,
hyperactivity,
endocrine
disorders,
reduced
fertility,
risk
dependence
on
illicit
substances.
Bacterial
decomposition
leads
new
intermediates
products
with
lower
toxicity.
Processes
such
membrane
filtration,
adsorption,
coagulation,
ozonation,
photocatalysis
have
also
been
shown
be
efficient
aqueous-phase
degradation.
breakdown
discussed.
review
demonstrates
that
high
efficiency
usually
achieved
expense
throughput.
For
scalable
application
degradation
technologies,
needs
remain
We
propose
need
process
intensification
using
an
integrated
combination
processes,
solve
multiple
associated
challenges.
Microplastics,
Journal Year:
2024,
Volume and Issue:
3(2), P. 217 - 233
Published: April 8, 2024
The
tremendous
plastic
production
and
poor
post-use
management
are
current
future
sources
of
environmental
human
contamination
due
to
their
degradation
products:
microplastics
nanoplastics
(MNPLs).
Methodological
developments
have
allowed
MNPLs
be
detected
in
an
increasing
variety
foods,
as
well
stool
colonic
mucosa.
It
was
suggested
early
that
the
direct
contact
between
intestinal
tissues
could
represent
a
potential
risk
for
health.
In
order
assess
this,
over
last
3
years,
numerous
studies
evaluated
impact
MNPL
ingestion
on
homeostasis
rodents.
This
comprehensive
review
reports
preclinical
published
January
2021
2024,
analyzes
contributions
shortcomings.
shows
evidence
is
accumulating
toxicity
spherical
MNPLs,
which
lead
pro-inflammatory,
pro-oxidative,
barrier-disruptive
dysbiotic
effects.
However,
available
literature
has
addressed
only
minor
part
health
issues
MNPLs.
Many
parameters
contributing
need
better
taken
into
account
studies.
Particular
attention
should
paid
improve
representativeness
consider
susceptibility
factors
toxicity,
generated
especially
by
underlying
pathology
or
pathological
imprinting.
Environment International,
Journal Year:
2024,
Volume and Issue:
191, P. 108948 - 108948
Published: Aug. 13, 2024
Bisphenol
A
(BPA)
and
its
substitute
fluorene-9-bisphenol
(BHPF)
are
used
in
consumer
products;
however,
their
toxic
effects
on
intestinal
epithelium
remain
largely
unknown.
In
this
study,
we
combined
organoids
single-cell
RNA
sequencing
to
investigate
the
impact
of
BPA
BHPF
exposure
cell
composition,
differentiation,
function.
Both
compounds
inhibited
growth
small
organoids,
with
exhibiting
a
more
potent
inhibitory
effect.
did
not
significantly
alter
overall
type
composition;
they
led
different
alterations
cell-cell
communications.
Gene
Ontology
enrichment
analysis
showed
that
exposures
affected
various
biological
processes,
such
as
glutathione
transferase
activity,
antioxidant
lipid
metabolism,
type-specific
compound-dependent
manners.
Trajectory
demonstrated
altered
differentiation
trajectory
cells.
To
further
connect
cellular
mechanism
phenotypic
vivo,
constructed
mouse
model
exposed
or
observed
significant
morphology,
including
reduced
crypt
depth
villus
length
impaired
stem
proliferation
self-renewal.
These
results
provide
novel
insights
into
highlight
potential
risks
these
compounds.
Our
findings
underscore
importance
evaluating
safety
substitutes
contribute
better
understanding
environmental
chemicals
gut
health.
