Association between urinary volatile organic compound metabolites and sarcopenia in the US general population: a cross-sectional NHANES study from 2011 to 2018

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 28, 2025

Volatile organic compound (VOC) is a prevalent form of pollutant that has been linked to various human ailments, yet their connection sarcopenia remains uncertain. This study seeks examine the potential association between exposure mixtures metabolites volatile compounds (mVOCs) and sarcopenia, while also investigating mediating effects oxidative stress inflammation. Data from 2011-2018 National Health Nutrition Examination Survey (NHANES) were utilized for analysis relationship mVOCs through logistic regression. The least absolute shrinkage selection operator (LASSO) regression model was employed identify key mVOCs, quantile-g computation (qgcomp) bayesian kernel machine (BKMR) models mVOC sarcopenia. Potential factors explored analysis. Of 2908 participants included in study, 246 individuals (8.5%) found have Logistic revealed five urinary VOC positively correlated with an increased risk identified LASSO method further analyzed using qgcomp, which showed 47% average increase when exposed mixture (OR = 1.47, 95% CI 1.14-1.91). Four components (DHBMA, 3HPMA, ATCA 3,4MHA) largest weight. BKMR results confirm this joint association. Furthermore, Mediation inflammation mediate In conclusion, our provides evidence suggesting heightened potentially serving as mediators relationship. It recommended additional cohort studies be conducted validate these findings.

Language: Английский

Effect of Zinc Supplementation on Altered Calcium Homeostasis, Parathyroid Gland, Bone, and Skeletal Muscle Histology Induced by Subchronic Oral Exposure to Glyphosate-Based Herbicide (GOBARA^®) in Wistar Rats

Clinical Pathology, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 1, 2024

The study was carried out to assess the effect of zinc supplementation on changes in calcium homeostasis, and parathyroid gland, bone, skeletal muscle histology rats exposed subchronic oral glyphosate-based herbicide (GBH, GOBARA

Language: Английский