Lead-free single and dual-filler loaded polychloroprene X-ray shielding nanocomposites DOI Creative Commons

Aklilu Getnet Messele,

Kalin Penev, Kibret Mequanint

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 42, P. 102558 - 102558

Published: Dec. 18, 2024

Language: Английский

Transcriptome analysis unveils the mechanisms of oxidative stress, immunotoxicity and neurotoxicity induced by benzotriazole UV stabilizer-328 in zebrafish embryos DOI Creative Commons
Xinlu Yang,

Yijing Gan,

Menghuan Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117822 - 117822

Published: Jan. 30, 2025

Language: Английский

Citations

0
Diselenide-based nanoparticles enhancing the radioprotection to the small intestine of mice DOI Creative Commons
Yichi Huang, Jiaze Li, Sen Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 22, 2025

The widespread application of ionizing radiation (IR) in medicine, while beneficial, also poses potential risks that necessitate effective countermeasures. Both 2-(3-aminopropylamino) ethanethiol (WR-1065) and curcumin are recognized as radioprotective agents; however, their clinical utility is hindered by notable shortcomings could be addressed through reactive oxygen species (ROS)-responsive amphiphilic nanomaterials. We introduced a newly synthesized poly (ethylene glycol) (PEG)-polycaprolactone (PCL) polymer integrated with diselenide bonds (HOOC-SeSe-Cur-PEG-SeSe-Cur-PCL, PEG-Cur-SeSe-PCL). resulting spherical nanoparticles (NPs), which self-assembled from this polymer, were uniform an average diameter 118 nm. As carrier for WR-1065, these NPs demonstrated loading capacity 30.9% efficacy 56.7%. Importantly, the degradation WR-1065 within was minimal gastric fluid, decreasing only approximately 20% over 6-hour period. innovative aspect design to destabilize ROS-rich environments, facilitating release curcumin. Indeed, survival rate mice increased 50% when orally administered prior exposure lethal dose whole-body irradiation (8 Gy). impact WR-1065-loaded evident small intestine irradiated mice, characterized amelioration radiation-induced epithelial damage, reduction DNA inhibition apoptotic pathway. Collectively, oral nanocarrier system holds promise candidate prophylaxis treatment acute intestinal injuries induced IR.

Language: Английский

Citations

0
Ursolic acid derivative UA312 ameliorates ionizing radiation-induced cardiotoxicity and neurodevelopmental toxicity in zebrafish via targeting chrna3 and grik5 DOI
Feifei Xu, Yue Shang, Hui‐Qiang Wei

et al.

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Citations

0
Mechanisms of Developmental Neurotoxicity of Dechlorane Plus, a Recently Identified Persistent Organic Pollutant: An In Silico Study DOI
Fuat Karakuş, Zübeyde Tanrıverdi, Burak Kuzu

et al.

NeuroToxicology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Lead-free single and dual-filler loaded polychloroprene X-ray shielding nanocomposites DOI Creative Commons

Aklilu Getnet Messele,

Kalin Penev, Kibret Mequanint

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 42, P. 102558 - 102558

Published: Dec. 18, 2024

Language: Английский

Citations

1