Genomic Regions Associated with Spontaneous Abortion in Holstein Heifers

Genes, Journal Year: 2024, Volume and Issue: 15(12), P. 1498 - 1498

Published: Nov. 22, 2024

Background/Objectives: The dairy industry relies on reproductive efficiency to maintain efficient milk production. Spontaneous abortion (SA), defined as pregnancy loss between gestation days 42 and 260, occurred in 4.5% of the artificially inseminated (AI) Holstein heifers 31.6% embryo transfer (ET) recipient that received vitro-produced frozen embryos a single farm Idaho. Methods: A genome-wide association analysis (GWAA) was performed identify associations (FDR p < 0.05) with SA were bred by AI (1351 controls delivered at term 63 cases aborted) conceived following first insemination, well 59 273 ET pregnant from ET. Results: There 216 loci 413 positional candidate genes associated recessive model no recipients. Conclusions: identification may be used reduce fetal through genomic selection.

Language: Английский

Prenatal Exposure of Pesticide Mixtures and the Placental Transcriptome: Insights from Trimester-specific, Sex-Specific and Metabolite-Scaled Analyses in the SAWASDEE Cohort

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120637 - 120637

Published: Dec. 1, 2024

Language: Английский