Urinary glyphosate, selenium status, and their impact on mortality: Evidence from NHANES 2013–2018 DOI Creative Commons
Pei‐Lun Chu, Ching-Chung Hsiao, Ta‐Chen Su

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117989 - 117989

Published: March 1, 2025

Glyphosate and glyphosate-based herbicides (GBHs), extensively used worldwide, have been associated with various health concerns, including an elevated risk of mortality. Experimental studies suggest that these may disrupt selenium homeostasis by hindering its uptake or promoting oxidative stress. However, the interplay between glyphosate exposure status remains poorly understood in epidemiological studies, particularly regarding selenium's role modulating mortality nationally representative populations. In this study, we analyzed data from 2013-2018 National Health Nutrition Examination Survey (NHANES), which included 6410 participants aged 3 years older. This dataset was linked to information Center for Statistics (NCHS) individuals 18 older, follow-up through 2019. The primary aim investigate relationships urinary levels, whole blood selenium, intake, influence on glyphosate-related all-cause risk. A significant negative correlation observed natural logarithm (ln) levels ln complex multiple linear regression models, a ß coefficient -0.010 (SE = 0.003, P 0.003). no association found intake. Furthermore, prominent among females, non-Hispanic whites, lower When examining relationship exposure, mortality, higher ln-urinary were significantly increased (Hazard Ratio [HR] 1.43; 95 % CI: 1.00-2.09). especially pronounced concentrations at above 50th percentile. Additionally, ln-whole protective effect against (HR 0.01; 0.00-0.18), strongest below comprehensive analysis NHANES data, our study identifies potentially harmful levels. Notably, excessively high not only reduce effects but could also increase suggesting U-shaped These findings highlight need further research into interaction status, emphasizing potential public implications.

Language: Английский

Calling for a comprehensive risk assessment of selenium in drinking water DOI Creative Commons
Marco Vinceti, R Mazzoli, Lauren A. Wise

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 966, P. 178700 - 178700

Published: Feb. 1, 2025

In the last two decades, research has elucidated that selenium, a trace element, both nutritional and toxicological effects on human health, depending its dose chemical form. Recent animal, laboratory, studies have shown harmful of certain selenium species at specific exposure levels, prompting need to reassess overall this including occurring through drinking water, primary source inorganic selenium. Drinking water standards worldwide are scarce existing inconsistent, likely because they been informed by an incomplete outdated assessment scientific evidence. Incorporating all available laboratory evidence into precautionary regulatory framework indicates limit around 5 μg/L is needed protect i.e. with uncertainty factor 2 versus lowest adverse effect level observed in studies, higher values may pose unacceptable risks humans. Despite rarity such high levels underground potable waters, coal mining other sources environmental pollution as well geological factors raise content above safe threshold, triggering consumers, face challenging technological issues for removal, currently under active investigation.

Language: Английский

Citations

0
Urinary glyphosate, selenium status, and their impact on mortality: Evidence from NHANES 2013–2018 DOI Creative Commons
Pei‐Lun Chu, Ching-Chung Hsiao, Ta‐Chen Su

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117989 - 117989

Published: March 1, 2025

Glyphosate and glyphosate-based herbicides (GBHs), extensively used worldwide, have been associated with various health concerns, including an elevated risk of mortality. Experimental studies suggest that these may disrupt selenium homeostasis by hindering its uptake or promoting oxidative stress. However, the interplay between glyphosate exposure status remains poorly understood in epidemiological studies, particularly regarding selenium's role modulating mortality nationally representative populations. In this study, we analyzed data from 2013-2018 National Health Nutrition Examination Survey (NHANES), which included 6410 participants aged 3 years older. This dataset was linked to information Center for Statistics (NCHS) individuals 18 older, follow-up through 2019. The primary aim investigate relationships urinary levels, whole blood selenium, intake, influence on glyphosate-related all-cause risk. A significant negative correlation observed natural logarithm (ln) levels ln complex multiple linear regression models, a ß coefficient -0.010 (SE = 0.003, P 0.003). no association found intake. Furthermore, prominent among females, non-Hispanic whites, lower When examining relationship exposure, mortality, higher ln-urinary were significantly increased (Hazard Ratio [HR] 1.43; 95 % CI: 1.00-2.09). especially pronounced concentrations at above 50th percentile. Additionally, ln-whole protective effect against (HR 0.01; 0.00-0.18), strongest below comprehensive analysis NHANES data, our study identifies potentially harmful levels. Notably, excessively high not only reduce effects but could also increase suggesting U-shaped These findings highlight need further research into interaction status, emphasizing potential public implications.

Language: Английский

Citations

0