Pregnancy as a Susceptible Period to Ambient Air Pollution Exposure on the Maternal Postpartum Metabolome DOI
Sandra India Aldana, Lauren Petrick, Megan M. Niedzwiecki

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Pregnancy is a potential critical window to air pollution exposure for long-term maternal metabolic effects. However, little known about early mechanisms linking health. We included 544 pregnant Mexican women with both ambient PM2.5 levels during pregnancy and untargeted serum metabolomics examine associations between (overall monthly) postpartum metabolites, implementing FDR-adjusted robust linear regression controlling covariates. Pathway enrichment analyses (in Reactome MetaboAnalyst) effect modification by fetal sex folic acid supplementation were also evaluated. Higher throughout associated higher bile acids amino acids, dysregulated glycerophospholipids, or lower fatty acyl (FDR < 0.05), among other metabolites. Potential windows of susceptibility monthly on metabolites observed in midpregnancy 0.005). Main findings consistent strata supplementation. Metabolic pathways corresponding positive PM2.5-metabolite indicated enriched acid, dietary lipid, transmembrane transport metabolism, whereas negative associations, we identified altered involving adipogenesis, incretin peptide hormone, GLP-1, PPAR-alpha, receptors 0.05). exposures pregnancy, especially gestation, lipids as well metabolism.

Language: Английский

Pregnancy as a Susceptible Period to Ambient Air Pollution Exposure on the Maternal Postpartum Metabolome DOI
Sandra India Aldana, Lauren Petrick, Megan M. Niedzwiecki

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Pregnancy is a potential critical window to air pollution exposure for long-term maternal metabolic effects. However, little known about early mechanisms linking health. We included 544 pregnant Mexican women with both ambient PM2.5 levels during pregnancy and untargeted serum metabolomics examine associations between (overall monthly) postpartum metabolites, implementing FDR-adjusted robust linear regression controlling covariates. Pathway enrichment analyses (in Reactome MetaboAnalyst) effect modification by fetal sex folic acid supplementation were also evaluated. Higher throughout associated higher bile acids amino acids, dysregulated glycerophospholipids, or lower fatty acyl (FDR < 0.05), among other metabolites. Potential windows of susceptibility monthly on metabolites observed in midpregnancy 0.005). Main findings consistent strata supplementation. Metabolic pathways corresponding positive PM2.5-metabolite indicated enriched acid, dietary lipid, transmembrane transport metabolism, whereas negative associations, we identified altered involving adipogenesis, incretin peptide hormone, GLP-1, PPAR-alpha, receptors 0.05). exposures pregnancy, especially gestation, lipids as well metabolism.

Language: Английский

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