Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 120121 - 120121
Published: Dec. 1, 2024
Language: Английский
Journal of Clinical Laboratory Analysis, Journal Year: 2024, Volume and Issue: 38(3)
Published: Jan. 24, 2024
Abstract Background Procalcitonin (PCT) is a critical biomarker that released in response to bacterial infections and can be used differentiate the pathogenesis of infectious process. Objective In this article, we provide an overview recent advances PCT biosensors, highlighting different approaches for biosensor construction, immobilization methods, advantages roles matrices used, analytical performance, construction. Also, will explain biosensors sensible limits detection (LOD), linearity, other characteristics. Future prospects development better systems are also discussed. Methods Traditional methods such as capillary electrophoresis, high‐performance liquid chromatography, mass spectrometry effective analyzing medical field, but they complicated, time‐consuming sample preparation, require expensive equipment skilled personnel. Results past decades, have emerged simple, fast, sensitive tools analysis various fields, especially fields. Conclusion These potential accompany or replace traditional by simplifying reducing preparation making field testing easier faster, while significantly cost per analysis.
Language: Английский
Citations
7
Journal of Clinical Laboratory Analysis, Journal Year: 2025, Volume and Issue: unknown
Published: March 13, 2025
ABSTRACT Background The recent rise in dengue virus (DENV) cases poses a significant threat to human health, with infections ranging from mild severe and potentially leading premature death. Objective To highlight the importance of early detection DENV review advancements technologies, particularly focusing on nanobiosensors. Methods This examines traditional methods for DENV, including molecular, serological, direct culture techniques, while discussing their limitations. It also explores innovative technologies that enhance accuracy, speed, efficiency. Results Nonstructural protein 1 (NS1) serves as key biomarker present high concentrations during stages infection, underscoring need timely detection. Traditional methods, effective, have limitations new aim address. Biosensors, nanobiosensors, emerged promising tools rapid, sensitive, cost‐effective Conclusion adoption advanced especially is crucial improving management reducing suffering. provides comprehensive overview nanobiosensors applications, presented an accessible manner readers.
Language: Английский
Citations
0
Theranostics, Journal Year: 2024, Volume and Issue: 14(11), P. 4411 - 4437
Published: Jan. 1, 2024
In recent years, gene therapy has been made possible with the success of nucleic acid drugs against sepsis and its related organ dysfunction.Therapeutics based on acids such as small interfering RNAs (siRNAs), microRNAs (miRNAs), messenger (mRNAs), plasmid DNAs (pDNAs) guarantee to treat previously undruggable diseases.The advantage acid-based lies in development nanocarriers, achieving targeted controlled delivery for improved efficacy minimal adverse effects.Entrapment into nanocarriers also ameliorates poor cellular uptake naked acids.In this study, we discuss current state art nanoparticles hyperinflammation apoptosis associated sepsis.The optimized design through physicochemical property modification ligand conjugation can target specific organs-such lung, heart, kidney, liver-to mitigate multiple sepsis-associated injuries.This review highlights nanomaterials designed fabricating anti-sepsis nanosystems, their characterization, mechanisms working sepsis, potential promoting therapeutic efficiency acids.The investigations nanoparticulate application management are summarized paper.Noteworthily, nanotherapeutic allows a novel strategy sepsis.Further clinical studies required confirm findings cell-and animal-based experiments.The capability large-scale production reproducibility nanoparticle products critical commercialization.It is expected that numerous possibilities will be investigated nanotherapeutics future.
Language: Английский
Citations
2
Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 565, P. 120013 - 120013
Published: Oct. 22, 2024
Language: Английский
Citations
2
Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 120121 - 120121
Published: Dec. 1, 2024
Language: Английский
Citations
2