Astaxanthin Inhibits Ferroptosis of Hippocampal Neurons in Kainic Acid‐Induced Epileptic Mice by Activating the Nrf2/GPX4 Signaling Pathway

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

ABSTRACT Background Epilepsy, a prevalent neurological disorder, is distinguished by episodic abnormal discharges of neurons within the brain, resulting in transient brain dysfunction. Prior research has identified novel form cell death termed ferroptosis, which intricately linked to initiation and progression epilepsy. It been demonstrated that astaxanthin (AST) can inhibit ferroptosis enhancing activity nuclear factor erythroid 2‐related 2 (Nrf2), thereby providing cytoprotection. Therefore, this study aims investigate whether AST alleviate neuronal epilepsy activating Nrf2/GPX4 pathway, exerting neuroprotective effect. Methods By constructing kainic acid (KA)‐induced mouse model KA‐induced HT22 model, we employed behavioral testing, Western blot analysis, quantitative real‐time reverse transcription qRT‐PCR, ferroptosis‐related assay kits, immunofluorescence staining, other methods. These methodologies were utilized protective effects underlying mechanisms on epileptic mice neurons. Results Our results demonstrate pretreatment alleviates behaviors cognitive impairments mitigates indicators such as lipid peroxidation mitochondrial morphological alterations. This effect appears be mediated activation signaling axis. In vitro studies further revealed confers neuroprotection against death, an abrogated Nrf2 inhibitor. Hence, properties are significantly associated with modulation Nrf2‐mediated corroborated bioinformatics analyses. Conclusion The effectively inhibits both vivo models via pathway. finding suggests holds promise potential therapeutic agent for treatment

Language: Английский

---

Association between severity of stroke and poststroke epilepsy among patients with ischemic stroke: Mediating role of infection and early seizure

Epilepsia, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Objective Despite extensive studies about the direct effect of stroke severity on poststroke epilepsy (PSE), pathway this relationship remains unclear. We examined whether stroke‐associated infection (SAI) and early seizure (ES) mediate association between PSE. Methods Patients with ischemic from two tertiary hospitals in China were included our retrospective cohort study. PSE was identified through telephone interviews based a validated questionnaire supplemented by review medical records. Stroke measured using National Institutes Health Scale (NIHSS) score, divided into four levels: mild (NIHSS score = 0–4), intermediate 5–9), moderate 10–14), severe ≥ 15). Mediation analysis applying Karlson–Holm–Breen method used to explore mediating SAI ES different levels Results A total 2420 patients analysis, 110 (4.5%) developed during follow‐up. associated SAI, ES, revealed that partially mediated After controlling for covariates, mediation proportion associations ranged 19.71% 29.27%. mediators accounted 28.17% Significance This highlighted need additional attention prevent

Language: Английский

---

The Association of Epileptic Seizures after Acute Ischemic Stroke with Cerebral Cortical Involvement and Electroencephalographic Changes

Medicina, Journal Year: 2024, Volume and Issue: 60(5), P. 768 - 768

Published: May 6, 2024

Background and objectives: while acute ischemic stroke is the leading cause of epilepsy in elderly population, data about its risk factors have been conflicting. Therefore, aim our study to determine association early late epileptic seizures after with cerebral cortical involvement electroencephalographic changes. Materials methods: a prospective cohort Hospital Lithuanian University Health Sciences Kaunas Clinics Department Neurology was conducted enrolled 376 patients. Data demographical, clinical, radiological, encephalographic changes gathered. Patients were followed for 1 year assessed ES. Results: incidence ES 4.5%, 2.7% 2.4%. The occurrence increased probability developing There no between damage ES, including both However, interictal epileptiform discharges associated

Language: Английский

---

Long-Term Safety and Efficacy of Lacosamide Combined with NOACs in Post-Stroke Epilepsy and Atrial Fibrillation: A Prospective Longitudinal Study

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1125 - 1125

Published: Nov. 27, 2024

Background and Aims: Stroke is the leading cause of seizures epilepsy in adults; however, current guidelines lack robust recommendations for treating post-stroke (PSSs) (PSE). This study aims to demonstrate long-term safety efficacy lacosamide combined with non-vitamin K antagonist oral anticoagulants (NOACs) patients PSE atrial fibrillation (AF). Methods: In this prospective longitudinal single-center study, 53 concomitant AF, admitted between 2022 2023, received NOACs AF management seizure control. A control group cardioembolic stroke, receiving (but without PSE), was matched by age, sex, NIHSS scores ensure comparability. Results: Over 24 months, 16 15 experienced new embolic events, no significant difference groups (p = 0.82). Seizure improved significantly group, reduced frequency severity. No severe adverse events from were observed. Conclusions: The combination a safe effective treatment does not increase risk recurrent ischemic or hemorrhagic events. Further studies larger sample sizes longer follow-ups are needed confirm these findings optimize protocols.

Language: Английский

---

Evaluating the Safety and Efficacy of Lacosamide Combined with NOACs in Post-Stroke Epilepsy and Atrial Fibrillation: A Prospective Longitudinal Study

Published: June 5, 2024

Background and Aims: Stroke is a leading cause of seizures epilepsy in adults, but current guidelines lack strong recommendations for treating post-stroke (PSE). This study aims to demonstrate the safety efficacy lacosamide combined with non-vitamin K antagonist oral anticoagulants (NOACs) patients PSE atrial fibrillation (AF). Methods: In this prospective longitudinal study, 53 AF, admitted from 2022 2023, received NOACs AF management seizure control. A control group cardioembolic stroke, receiving NOACs, was matched by age, sex, NIHSS scores ensure comparability. Results: Over 24 months, 16 15 experienced new embolic events, no significant difference between groups. Seizure improved significantly group, reduced frequency severity. No severe adverse effects were observed. Conclusions: The combination safe effective treatment PSE, not increasing risk recurrent ischemic or hemorrhagic events. Further studies larger sample sizes longer follow-ups are needed confirm these findings optimize protocols.

Language: Английский

---

Poststroke seizures and epilepsy increase the risk of dementia among stroke survivors: A population‐based study

Epilepsia, Journal Year: 2024, Volume and Issue: 65(11), P. 3244 - 3254

Published: Sept. 10, 2024

Abstract Objective With global aging, the occurrence of stroke and associated outcomes like dementia are on rise. Seizures epilepsy common poststroke complications have a strong connection to subsequent dementia. This study examines relationship between seizures (PSS) or (PSE) using national health care database. Methods We conducted retrospective data from Taiwan National Health Insurance Research Database 2009 2020. identified acute patients 2010 2015, excluding those with pre‐existing neurological conditions. Based age, sex, severity level, year index stroke, PSS PSE were matched without. The main outcome was incident Results included 62 968 an average age 63 years, males accounting for 62.9%. Of them, 60.3% had ischemic strokes, 39.7% hemorrhagic strokes. After follow‐up period 5.2 developed in 15.9% who PSE, as opposed 8.4% without these A time‐dependent Fine Gray competing risk analysis showed that significantly across all types. Subgroup analyses revealed increased groups (<50, 50–64, ≥65 years), sexes, various levels. link particularly pronounced men, less distinct correlation women. Significance higher PSE. potential therapeutic interventions reduce underscores importance seizure screening treatment survivors.

Language: Английский

---

Prophylactic Administration of Perampanel for Post-Stroke Epilepsy (PROPELLER Study): A Trial Protocol

Methods and Protocols, Journal Year: 2024, Volume and Issue: 7(5), P. 79 - 79

Published: Oct. 5, 2024

Post-stroke epilepsy can reduce patients' abilities to carry out various activities of daily living. Despite their importance in preventing the onset post-stroke epilepsy, prophylactic administration antiepileptic drugs is controversial due a lack high-level clinical research. In this study, we initiated prospective interventional study drug patients with subcortical hemorrhage, who are at highest risk developing after experiencing stroke.

Language: Английский

---