Flavonoids as therapeutic agents for epilepsy: unveiling anti-inflammatory and antioxidant pathways for novel treatments DOI Creative Commons
Ya Zhang, Xizhuo Hu, Liqun Zou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 12, 2024

Epilepsy, a chronic neurological disorder affecting millions globally, is often exacerbated by neuroinflammation and oxidative stress. Existing antiepileptic drugs primarily manage symptoms, leaving the disease's progression largely unaddressed. Flavonoids, ubiquitous plant metabolites with potent anti-inflammatory antioxidant properties, show promise in epilepsy treatment. Unlike conventional therapies, they target multiple pathophysiological processes simultaneously, offering comprehensive approach to this complex disorder. This review explores dual role of flavonoids mitigating reducing stress through various molecular pathways. By inhibiting key inflammatory mediators pathways such as NF-κB, MAPK, JNK, JAK, offer neuronal protection. They enhance body's natural defenses modulating enzyme activities, including superoxide dismutase, catalase, glutathione peroxidase. Moreover, influence crucial response like PI3K/AKT, Nrf2, PKA. Despite their therapeutic promise, low bioavailability poses considerable challenge. However, cutting-edge strategies, nanotechnology chemical modifications, are underway improve efficacy. These advancements support potential valuable addition treatment strategies.

Language: Английский

Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence DOI Creative Commons

Enzo Pereira de Lima,

Lucas Fornari Laurindo,

Vitor Cavallari Strozze Catharin

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 124 - 124

Published: Feb. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Language: Английский

Citations

7
Role of Plant Phytochemicals: Resveratrol, Curcumin, Luteolin and Quercetin Indemyelination, Neurodegeneration, and Epilepsy DOI Creative Commons
M Grabarczyk,

Weronika Justyńska,

Joanna Czpakowska

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1364 - 1364

Published: Nov. 7, 2024

Polyphenols are an important group of biologically active compounds present in almost all food sources plant origin and primarily known for their anti-inflammatory antioxidative capabilities. Numerous studies have indicated broad spectrum pharmacological properties correlations between increased supply the human diet lower prevalence various disorders. The positive effects polyphenols application mostly discussed terms cardiovascular system well-being. However, recent years, they also increasingly mentioned as prophylactic therapeutic factors context neurological diseases, being able to suppress progression such disorders soothe accompanying symptoms. Among over 8000 compounds, that been identified, most widely examined comprise resveratrol, curcumin, luteolin quercetin. This review focuses on vitro assessments, animal models clinical trials, reflecting actual state knowledge, polyphenols' medicinal capabilities epilepsy, demyelinating neurodegenerative diseases central nervous system.

Language: Английский

Citations

9
Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action DOI Creative Commons
Abdul Waris, Ata Ullah, Muhammad Asim

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 24, 2024

Epilepsy is one of the most common, severe, chronic, potentially life-shortening neurological disorders, characterized by a persisting predisposition to generate seizures. It affects more than 60 million individuals globally, which major burdens in seizure-related mortality, comorbidities, disabilities, and cost. Different treatment options have been used for management epilepsy. More 30 drugs approved US FDA against However, one-quarter epileptic still show resistance current medications. About 90% low middle-income countries do not access medication. In these countries, plant extracts treat various diseases, including These medicinal plants high therapeutic value contain valuable phytochemicals with diverse biomedical applications. multifactorial disease, therefore, multitarget approaches such as or extracted are needed, can target multiple pathways. Numerous shown epilepsy animal models targeting receptors, enzymes, metabolic could be humans future; however, further research needed study exact mechanism action, toxicity, dosage reduce their side effects. this narrative review, we comprehensively summarized species purified isolated from plants, targets

Language: Английский

Citations

6
Flavonoids as therapeutic agents for epilepsy: unveiling anti-inflammatory and antioxidant pathways for novel treatments DOI Creative Commons
Ya Zhang, Xizhuo Hu, Liqun Zou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 12, 2024

Epilepsy, a chronic neurological disorder affecting millions globally, is often exacerbated by neuroinflammation and oxidative stress. Existing antiepileptic drugs primarily manage symptoms, leaving the disease's progression largely unaddressed. Flavonoids, ubiquitous plant metabolites with potent anti-inflammatory antioxidant properties, show promise in epilepsy treatment. Unlike conventional therapies, they target multiple pathophysiological processes simultaneously, offering comprehensive approach to this complex disorder. This review explores dual role of flavonoids mitigating reducing stress through various molecular pathways. By inhibiting key inflammatory mediators pathways such as NF-κB, MAPK, JNK, JAK, offer neuronal protection. They enhance body's natural defenses modulating enzyme activities, including superoxide dismutase, catalase, glutathione peroxidase. Moreover, influence crucial response like PI3K/AKT, Nrf2, PKA. Despite their therapeutic promise, low bioavailability poses considerable challenge. However, cutting-edge strategies, nanotechnology chemical modifications, are underway improve efficacy. These advancements support potential valuable addition treatment strategies.

Language: Английский

Citations

3