Toxicant Actions: Mode of Action of Endocrine Disruptors

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Endocrine disruptors in personal care products and cosmetics: Sample preparation and analysis- evaluation of green and blue characteristics

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113769 - 113769

Published: April 1, 2025

Language: Английский

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Mitigation of PFOA-Induced Developmental Toxicity in Danio rerio by Bacillus subtilis var. natto: Focus on Growth and Ossification

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4261 - 4261

Published: April 30, 2025

Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that resists biological degradation and accumulates in organisms. It disrupts zebrafish embryo development, affecting their heartbeat rate locomotion. Meanwhile, probiotics are known to enhance the development ossification of embryos. In this study, we examined toxic effects PFOA on growth bone formation potential probiotic Bacillus subtilis var. natto counteract its toxicity. Larvae were exposed 0, 50, or 100 mg/L from hatching 21 days post-fertilization (dpf), with without dietary supplementation (107 CFU/larva/day), they sampled at 7, 14, dpf. exposure reduced standard length dpf, while co-administration mitigated these effects. Craniofacial cartilage defects appeared larvae 50 7 14 impaired Probiotics counteracted abnormalities. also delayed ossification, correlating downregulation col10a1a, runx2b, cyp26b1, treatment restored normal ossification. These findings improve our understanding PFOA’s detrimental demonstrating protective role against PFOA-induced developmental

Language: Английский

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The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system

Biology of Reproduction, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Endocrine-disrupting chemicals are natural and synthetic compounds found ubiquitously in the environment that interfere with hormonal-immune axis, potentially impacting human health reproduction. Exposure to endocrine-disrupting has been associated numerous risks, such as neurodevelopmental disorders, metabolic syndrome, thyroid dysfunction, infertility, cancers. Nevertheless, current approach establishing causality between these substances disease outcomes limitations. Epidemiological experimental research on faces challenges accurately assessing chemical exposure interpreting non-monotonic dose response curves. In addition, most studies have focused single or simple mixtures, overlooking complex real-life exposures mechanistic insights, particular regarding chemicals' impact immune system. The ENDOMIX project, funded by EU’s Horizon Health Program, addresses integrating epidemiological, risk assessment, immunotoxicology methodologies. This systemic comprises triangulation of cohort, vitro, vivo data determine combined effects mixtures. present review presents discusses literature reproduction context immunotolerance disruption mode action. It further underscores perspective elucidate immune-reproductive health.

Language: Английский

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Editorial: The role of thyroid hormones in vertebrate development, volume II

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 17, 2024

Citation: Campinho MA and Sachs LM (2024) Editorial: The role of thyroid hormones in vertebrate development, volume II. Front. Endocrinol. 15:1408070. doi: 10.3389/fendo.2024.1408070

Language: Английский

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Associations between Exposure to Sodium/Iodide Symporter Inhibitors and Thyroid Function: A Systematic Review and Meta-Analysis

Published: Jan. 1, 2024

Language: Английский

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The Interplay of the Mammalian Brain and Thyroid Hormones, and the Threat of Endocrine-Disrupting Chemicals

Endocrines, Journal Year: 2024, Volume and Issue: 5(4), P. 501 - 515

Published: Oct. 25, 2024

Introduction: During the formation of neural circuits, developing brain demonstrates extraordinary plasticity, heavily influenced by hormones. These chemical messengers interact with specific receptors to regulate vital physiological functions. The thyroid gland plays a pivotal role in maintaining hormonal balance and guiding development. However, emerging threats like endocrine-disrupting chemicals (EDCs) can interfere this intricate system. EDCs are exogenous substances that mimic, enhance, or block actions endogenous hormones, disrupting signaling at various developmental stages. Exposure impair cognitive function behavior due disruptions function. Studies indicate mixtures negatively impact development, leading lower IQ behavioral problems. Reducing EDC exposure through regulations public awareness is crucial, further research needed elucidate their mechanisms. Conclusions: Protecting vulnerable populations, such as pregnant women children, essential prompt regulatory measures.

Language: Английский

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Iodine and Hyperthyroidism: A Double-Edged Sword

Endocrine Practice, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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