Influence of para-substituted benzaldehyde derivatives with different push/pull electron strength groups on the conformation of human serum albumin and toxicological effects in zebrafish

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131246 - 131246

Published: March 28, 2024

Language: Английский

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Strong binding between nanoplastic and bacterial proteins facilitates protein corona formation and reduces nanoplastics toxicity

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175433 - 175433

Published: Aug. 11, 2024

Language: Английский

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Adsorption of clarithromycin on polystyrene nanoplastics surface and its combined adverse effect on serum albumin

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 234, P. 113673 - 113673

Published: Dec. 1, 2023

Language: Английский

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Unveiling the Modification of Esterase-like Activity of Serum Albumin by Nanoplastics and Their Cocontaminants

ACS Omega, Journal Year: 2023, Volume and Issue: 8(46), P. 43719 - 43731

Published: Nov. 6, 2023

Nanoplastics and other cocontaminants have raised concerns due to their widespread presence in the environment potential enter food chain. The harmful effects of these particles depend on various factors, such as nanoparticle size, shape, surface charge, nature involved. On entering human body, serum albumin (HSA) molecules bind transport blood system. esterase-like activity HSA, which plays a role metabolizing drug/toxic compounds, was taken representative portray HSA. Polystyrene nanoplastics (PSNPs) with different functionalization (plain (PS), amine (PS-NH2), carboxy (PS-COOH)), sizes (100 500 nm), PS cocontaminant metformin hydrochloride (Met-HCl), widely used antidiabetic drug, were investigated this study. Fluorescence emission spectra HSA revealed that PS-NH2 exhibits greater effect protein conformation, smaller NPs influence structure than larger NPs, Met-HCl lowers PSNPs' affinity for by coating may result direct NP distribution drug's target organs toxicity. Circular dichroism also supported results terms secondary structural changes. Esterase inhibited all (except Met-HCl) competitive inhibition concluded from constant Vmax increasing Km. Greater reduction enzyme observed among functionalizations 100 nm sizes. Furthermore, inhibitory impact PSNPs since drug binds weakly so they can serve vector delivering organs, resulting serious implications.

Language: Английский

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Surface functionalization, particle size and pharmaceutical co-contaminant dependent impact of nanoplastics on marine crustacean – Artemia salina

Environmental Science Processes & Impacts, Journal Year: 2024, Volume and Issue: 26(7), P. 1130 - 1146

Published: Jan. 1, 2024

Despite a significant amount of research on micronanoplastics (MNPs), there is still gap in our understanding their function as transporters other environmental pollutants (known the Trojan horse effect) and combined effects ingestion, bioaccumulation, toxicity to organisms. This study examined individual polystyrene nanoplastics (PSNPs) with various surface functionalizations (plain (PS), carboxylated (PS-COOH), aminated (PS-NH2)), particle sizes (100 nm 500 nm), pharmaceutical co-contaminant (metformin hydrochloride (MH), an anti-diabetic drug) marine crustacean - Artemia salina. The specifically aimed determine if MH alters detrimental PSNPs A. potential these emerging was assessed by examining mortality, hatching rate, morphological changes, biochemical changes. Smaller nanoparticles had more impact than larger ones, PS-NH2 harmful PS PS-COOH. Exposure nanoparticle complex resulted decrease increase developmental abnormalities, reactive oxygen species, catalase, lipid peroxidase, total protein superoxide dismutase, indicating synergistic effect. There were no differences between nanoparticles. However, accumulating particles organisms could contaminate food chain. These results highlight risks associated simultaneous exposure aquatic species plastics, particularly smaller PS, PS.

Language: Английский

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Investigating the impact of nanoplastics in altering the efficacy of Clarithromycin antibiotics through In vitro studies

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125144 - 125144

Published: Oct. 1, 2024

Language: Английский

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