Uncovering layer by layer the risk of nanoplastics to the environment and human health DOI
Joana Antunes, Paula Sobral, Vasco Branco

et al.

Journal of Toxicology and Environmental Health Part B, Journal Year: 2024, Volume and Issue: 28(2), P. 63 - 121

Published: Dec. 13, 2024

Nanoplastics (NPs), defined as plastic particles with dimensions less than 100 nm, have emerged a persistent environmental contaminant potential risk to both environment and human health. might translocate across biological barriers accumulate in vital organs, leading inflammatory responses, oxidative stress, genotoxicity, already reported several organisms. Disruptions cellular functions, hormonal balance, immune responses were also linked NPs exposure vitro assays. Further, been found adsorb other pollutants, such organic pollutants (POPs), leach additives potentially amplifying their advere impacts, increasing the threat organisms greater alone. However, toxic effects remain largely unexplored, requiring further research elucidate risks health, especially accumulation, degradation, migration, interactions systems long-term consequences of chronic these compounds. This review provides an overview current state-of-art regarding mechanisms toxicity within cells.

Language: Английский

Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-κB/NLRP3 pathways and related gut-liver axis in mice DOI
Xuanwei Chen, Xuan Yang, Ya‐Wen Chen

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 935, P. 173458 - 173458

Published: May 23, 2024

Language: Английский

Citations

14
Genotoxic and neurotoxic potential of intracellular nanoplastics: A review DOI
Claudio Casella, Santiago Ballaz

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: 44(11), P. 1657 - 1678

Published: March 17, 2024

Abstract Plastic waste comprises polymers of different chemicals that disintegrate into nanoplastic particles (NPLs) 1–100‐nm size, thereby littering the environment and posing a threat to wildlife human health. Research on NPL contamination has up now focused ecotoxicology effects pollution rather than health risks. This review aimed speculate about possible properties carcinogenic neurotoxic as pollutants. Given their low‐dimensional size high surface ratio, NPLs can easily penetrate biological membranes cause functional structural damage in cells. Once inside cell, interrupt autophagy flux cellular debris, alter proteostasis, provoke mitochondrial dysfunctions, induce endoplasmic reticulum stress. Harmful metabolic processes induced by include oxidative stress (OS), ROS generation, pro‐inflammatory reactions. Depending cell cycle status, may direct DNA damage, tumorigenesis, lately carcinogenesis tissues with self‐renewal capabilities like epithelia. In cells able live longest neurons, could trigger neurodegeneration promoting toxic proteinaceous aggregates, OS, chronic inflammation. genotoxicity neurotoxicity are discussed based gathered evidence, when available, within context intracellular uptake these newcomer nanoparticles. summary, this explains how risk evaluation for benefit from accurately monitoring toxicokinetics toxicodynamics at resolution level.

Language: Английский

Citations

8
Polystyrene nanoplastics exacerbate aflatoxin B1-induced hepatic injuries by modulating the gut−liver axis DOI

Kai-Kai Zhang,

Jia-Yuan Wan,

Yu‐Chuan Chen

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 935, P. 173285 - 173285

Published: May 19, 2024

Language: Английский

Citations

7
Micro(nano)plastics: an Emerging Burden for Human Health DOI Creative Commons

Isabella Donisi,

Antonino Colloca,

Camilla Anastasio

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(14), P. 5779 - 5792

Published: Oct. 21, 2024

The escalation of plastic pollution represents a global environmental and health problem. Important toxic effects have been attributed to the increasing diffusion microplastics (MPs) nanoplastics (NPs) derived from degradation plastics. These particles ubiquitously observed in environment, with humans being continuously exposed via ingestion, inhalation skin contact. Nonetheless, cellular homeostasis imbalance induced by micro- nano- plastics (MNPs) human has only recently shown, while most evidence molecular mechanisms studies

Language: Английский

Citations

5
Microplastics and Nanoplastics as Environmental Contaminants of Emerging Concern: Potential Hazards for Human Health DOI Open Access
Rita Khanna, Abhilash P. Chandra,

Shaundeep Sen

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(19), P. 8704 - 8704

Published: Oct. 9, 2024

With nearly 40% of the total plastics produced being used for packaging, up to five trillion plastic bags are consumed in world annually. The inadequate disposal waste and its persistence has become a serious challenge/risk environment, health, well-being living creatures, including humans. natural degradation is extremely slow; large pieces may break down into microplastics (MPs) (1 μm–5 mm) or nanoplastics (NPs) (<1000 nm) after protracted physical, chemical, and/or biological degradations. A brief overview transport micro- aquatic, terrestrial, atmospheric environments presented. Details provided on exposure routes these materials their entry humans other biota through ingestion, inhalation, dermal contact. greatest concern cumulative impact heterogeneous secondary MPs NPs planetary human health. Inhaled have been shown affect upper respiratory tract, lower alveoli; prolonged can lead chronic inflammatory changes systemic disease. These also autoimmune diseases health conditions, atherosclerosis malignancy. Sustainable mitigation strategies reduce MPs/NPs include source reduction, material substitution, filtration purification, transformation value-added materials, technological innovations, etc. Multidisciplinary collaborations across fields medicine, public environmental science, economics, policy required help limit detrimental effects widespread environment.

Language: Английский

Citations

4
Role of microplastics in the tumor microenvironment (Review) DOI Open Access
Yunjie Chen, Zihang Zhang,

Kangming Ji

et al.

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4), P. 1 - 14

Published: Feb. 21, 2025

Microplastics (MPs) are pervasive in several ecosystems and have the potential to infiltrate multiple aspects of human life through ingestion, inhalation dermal exposure, thus eliciting substantial concerns regarding their implications for health. Whilst initial research has documented effects MPs on disease development across physiological systems, may also facilitate tumor progression by influencing microenvironment (TME). This evolving focus underscores growing interest role tumorigenesis interactions within TME. In present review, relationship between TME is comprehensively assessed, providing a detailed analysis with cells, stromal cells (including macrophages, fibroblasts endothelial cells), extracellular matrix inflammatory processes. Recommendations future directions strategies address reduce microplastic pollution proposed.

Language: Английский

Citations

0
Toxicological effects of micro/nanoplastics and benzo[a]pyrene on cellular and molecular responses of Apostichopus japonicus (Selenka, 1867) during intestinal regeneration DOI
Ji Liu,

Yanru Chen,

Baiqin Sun

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 491, P. 138003 - 138003

Published: March 19, 2025

Language: Английский

Citations

0
Microplastics/nanoplastics and Neurological Health: An Overview of Neurological Defects and Mechanisms DOI
Junjie Sun,

Siwan Peng,

Qiongxia Yang

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 511, P. 154030 - 154030

Published: Dec. 7, 2024

Language: Английский

Citations

2
Can evolutionary immunology decode micro and nanoplastic challenges? DOI Creative Commons
Andi Alijagić, Eva Särndahl

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 17, 2024

Keywords: innate immunity, particles, environmental species, humans, pattern recognition receptors (PRRs)

Language: Английский

Citations

0
Biobased, Biodegradable but not bio-neutral: about the effects of polylactic acid nanoparticles on macrophages DOI

Véronique Collin‐Faure,

Marianne Vitipon,

Hélène Diemer

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Abstract Plastics are persistent pollutants, because of their slow degradation, which suggests that they may lead to cumulative and/or delayed adverse effects due progressive accumulation over time. Macroplastics produced by human activity released in the environment, where degrade into micro and nanoplastics very easily uptaken a wide variety organisms, including humans. Microplastics being particulates, handled body specialized cells such as macrophages (or evolutionary counterparts), can elicit responses. One solution alleviate problems biopersistence, life, would be use biodegradable plastics. emerging plastics polylactide, we decided test responses polylactide nanoparticles, using combination untargeted proteomics targeted validation experiments. Proteomics showed important adaptive changes proteome response exposure nanoparticles. These affected for example mitochondrial, cytoskeletal lysosomal proteins, but also proteins implicated immune functions or redox homeostasis. Validation experiments many these were homeostatic, with no induced oxidative stress gross perturbation mitochondrial function. However, particles altered phagocytosis (−20%) cytokine production (2-fold increase TNF production), translate decreased ability respond bacterial infections. Furthermore, moderate cross-toxicity some quinones phenanthrene quinone, combustion by-product is suspected carcinogen.

Language: Английский

Citations

0