Particulate Matter-Induced Emerging Health Effects Associated with Oxidative Stress and Inflammation
Eun Yeong Lim,
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Gun-Dong Kim
No information about this author
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(10), P. 1256 - 1256
Published: Oct. 17, 2024
Environmental
pollution
continues
to
increase
with
industrial
development
and
has
become
a
threat
human
health.
Atmospheric
particulate
matter
(PM)
was
designated
as
Group
1
carcinogen
by
the
International
Agency
for
Research
on
Cancer
in
2013
is
an
emerging
global
environmental
risk
factor
that
major
cause
of
death
related
cardiovascular
respiratory
diseases.
PM
complex
composed
highly
reactive
organic
matter,
chemicals,
metal
components,
which
mainly
excessive
production
oxygen
species
(ROS)
can
lead
DNA
cell
damage,
endoplasmic
reticulum
stress,
inflammatory
responses,
atherosclerosis,
airway
remodeling,
contributing
increased
susceptibility
exacerbation
various
diseases
infections.
effects
health
depending
particle
size,
physical
chemical
characteristics,
source,
exposure
period.
smaller
than
5
μm
penetrate
accumulate
alveoli
circulatory
system,
causing
harmful
skin,
brain.
In
this
review,
we
describe
relationship
mechanism
ROS-mediated
oxidative
responses
caused
organs,
well
comprehensively
discuss
harmfulness
PM.
Language: Английский
Identification of particulate matter (PM10 and PM2.5) sources using bivariate polar plots and k-means clustering in a South American megacity: Metropolitan Area of Lima-Callao, Peru
Environmental Monitoring and Assessment,
Journal Year:
2025,
Volume and Issue:
197(3)
Published: Feb. 3, 2025
Language: Английский
Epigenetics and Chromatin Remodeling
Elsevier eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Language: Английский
In vitro genotoxic and mutagenic potentials of combustion particles from marine fuels with different sulfur contents
Environment International,
Journal Year:
2025,
Volume and Issue:
unknown, P. 109440 - 109440
Published: April 1, 2025
Language: Английский
Exploring the mechanism of sesamin for the treatment of PM2.5-induced cardiomyocyte damage based on transcriptomics, network pharmacology and experimental verification
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 5, 2024
Introduction
Exposure
to
fine
particulate
matter
(PM
2.5
)
is
known
be
associated
with
cardiovascular
diseases.
Sesamin
(Ses)
a
natural
phenolic
compound
found
in
sesame
seeds
and
oil.
Ferroptosis
novel
mode
of
cell
death
characterised
by
iron-dependent
lipid
peroxidation.
This
study
aims
explore
whether
PM
can
induce
ferroptosis
H9C2
cells
investigate
the
precise
protective
mechanism
Ses.
Methods
Based
on
transcriptomic
data,
may
cardiomyocytes.
The
inducer
erastin
inhibitor
ferrostatin-1
(Fer-1)
were
used
illustrate
mechanisms
involved
-induced
injury.
Using
network
pharmacology,
pharmacological
potential
therapy
targets
Ses
explored
for
treatment
cardiomyocyte
cultured
pretreated
Fer-1
or
different
concentrations
Ses,
then
injury
model
was
established
using
.
Indicators
oxidative
responses,
including
total
superoxide
dismutase,
reduced
glutathione,
glutathione
peroxidase
malondialdehyde,
measured.
expression
levels
ferroptosis-related
proteins
determined
through
Western
blot
analysis.
Results
demonstrate
that
induces
exerts
effect
suppressing
ACSL4-mediated
ferroptosis.
Discussion
Overall,
these
findings
elucidate
which
ameliorates
detrimental
effects
Language: Английский