Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 30, 2025

Abstract Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding complexities of tumor development and mutation need hour for advancement targeted therapies cancer care. A significant innovation this area use nanotechnology, specifically nanoparticles, tackle various challenges treatment. Iron oxide nanoparticles stand out both therapeutic diagnostic applications, offering versatile platform drug delivery, hyperthermia, magneto-thermal therapy, combinational therapy using modulation ferroptosis pathways. These are easy synthesize, non-toxic, biocompatible, display enhanced circulation time within system. They can also be easily conjugated anti-cancer drugs, targeting agents, or genetic vectors that respond specific stimuli pH changes. The surface functionalization these bioactive molecules unveils promising effective nanoparticle system assisting osteosarcoma therapy. This review will summarize current conventional their disadvantages, synthesis modification iron documented literature, cellular uptake mechanism, with focus on natural biomaterials application strategies towards management osteosarcoma. compiles translational future prospects must addressed clinical advancements based treatment future. Graphical abstract

Language: Английский

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Unraveling the Structure and Properties of High-Concentration Aqueous Iron Oxide Nanocolloids Free of Steric Stabilizers

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Aqueous colloids with a high concentration of nanoparticles and free steric stabilizers are prospective soft materials, the engineering which is still challenging. Herein, we prepared superparamagnetic very large, up to 1350 g/L 11 nm via Fe2+ Fe3+ coprecipitation, water washing, purification using cation-exchange resin, stabilization monolayer citrate anions (ζ potential diluted dispersions about -35 mV). XRD, XPS, Mössbauer, FTIR spectra elucidated defective reverse spinel structure magnetite/maghemite (Fe3O4/γ-Fe2O3) reduced content cations. The viscosity increases nanoparticle depends also on nature salt, being one order magnitude lower for lithium than sodium potassium as counter-cation. SAXS/USAXS curves show power-law behavior in scattering vector range between 0.1 0.002 nm-1, suggesting that particles interact forming fractal clusters, looser Na+- denser Li+-citrate (fractal dimensions 1.9 2.4, respectively). In parallel, ATR-FTIR found increasing proportions symmetric O-H stretching vibrations ice-like interfacial concentrated colloids. We hypothesize clusters arise due attraction like-charge possibly involving shells hydration counter-cations; overlapping transition continuous non-Newtonian phases seen at vs plots 700-900 g/L. results shed new light nanocolloids pave way their manufacturing tailoring.

Language: Английский

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Green nanotechnologies for removing cosmetic pollutants: approach towards preserving and protecting aquatic health

Nanotechnology for Environmental Engineering, Journal Year: 2025, Volume and Issue: 10(2)

Published: March 13, 2025

Language: Английский

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Source Identification and Potential Ecological Risk Assessment of Heavy Metals in the Topsoil of the Weining Plain (Northwest China)

Exposure and Health, Journal Year: 2021, Volume and Issue: 14(2), P. 281 - 294

Published: Oct. 29, 2021

Language: Английский

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Bioremediation and decontamination potentials of metallic nanoparticles loaded nanohybrid matrices – A review

Environmental Research, Journal Year: 2021, Volume and Issue: 204, P. 112407 - 112407

Published: Nov. 18, 2021

Language: Английский

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