Feruloylacetone and Its Analog Demethoxyferuloylacetone Mitigate Obesity-Related Muscle Atrophy and Insulin Resistance in Mice

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Obesity-induced muscle alterations, such as inflammation, metabolic dysregulation, and myosteatosis, lead to a decline in mass function, often resulting sarcopenic obesity. Currently, there are no definitive treatments for obesity beyond lifestyle changes dietary supplementation. Feruloylacetone (FER), thermal degradation product of curcumin, its analog demethoxyferuloylacetone (DFER), derived from the bisdemethoxycurcumin, have shown potential antiobesity effects previous studies. This study investigates impact FER DFER on obesity-related glucose intolerance atrophy. High-fat diet (HFD) feeding resulted reduction increased intramuscular triglyceride accumulation, both which were mitigated by The supplements activated PI3K/Akt/mTOR signaling pathway, enhanced protein synthesis, decreased markers degradation. Additionally, supplementation improved homeostasis HFD-fed mice. also promoted formation gut microbial consortium comprising Blautia intestinalis, Dubosiella newyorkensis, Faecalicatena fissicatena, Waltera Clostridium viride, Caproiciproducens galactitolivorans, contributed obesity-induced chronic inflammation. These findings suggest, first time, that may prevent complications, including atrophy insulin resistance, thereby warranting further research into their long-term efficacy safety.

Language: Английский

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Waste-to-resource caproic acid production by anaerobic mixed microbial cultures: A review of recent developments

Biomass and Bioenergy, Journal Year: 2025, Volume and Issue: 197, P. 107769 - 107769

Published: March 14, 2025

Language: Английский

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Steering yeast-bacteria synergy by biochar to achieve enhanced endogenous ethanol-driven chain elongation

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162013 - 162013

Published: March 1, 2025

Language: Английский

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Feedback of chain elongation microorganisms on iron-based conductive materials: Enhanced microbial functions and biotoxicity adaptation mechanisms

Bioresource Technology, Journal Year: 2024, Volume and Issue: 406, P. 130959 - 130959

Published: June 12, 2024

Language: Английский

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Carbon Chain Elongation Characterizations of Electrode-Biofilm Microbes in Electro-fermentation

Water Research, Journal Year: 2024, Volume and Issue: 267, P. 122417 - 122417

Published: Sept. 8, 2024

Language: Английский

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Beyond Anaerobic Digestion: New Perspectives for the Development of a Biorefinery Platform for the Simultaneous Production of Medium-Chain Fatty Acids by Chain Elongation and Biogas from Food Wastes

ACS Sustainable Chemistry & Engineering, Journal Year: 2024, Volume and Issue: 12(42), P. 15294 - 15306

Published: Oct. 9, 2024

The medium chain fatty acids (MCFAs) obtained via elongation of short are becoming a trend topic in the field biorefinery research. Their synthesis can be implemented over 150 000 full-scale anaerobic digestion plants around world, increasing economic revenues derived from mere biogas production. This paper offers critical insight into needed actions for creation model simultaneous production MCFAs and organic fraction municipal solids wastes most abundant food wastes, such as brewery grape pomace, cheese whey. A three-stage process was suggested with aim to optimize operational parameters pretreatments purification all compounds involved process: (i) electron donor, (ii) acceptor compounds, (iii) their reaction separate reactor MCFAs. remaining matter fermentation steps donor molecules sent already-existing AD plant Specifically, it emphasized that molar ratio between (ethanol or lactate) (volatile acids, VFAs) ranges 3:1 6:1 yield. Regarding configuration, batch mode not able ensure high yield, while continuous operating at hydraulic retention time (HRT) 5–10 days neutral slightly acidic pH led conversion (25–50% (w/w)). Nanofiltration pertraction were best techniques recover other very yields range 75%–95%. applications different fields: jet diesel fuels polyhydroxyoctanoate polyhydroxydecanoate biosynthesis. Finally, main challenges implementation discussed emphasized: among them, low concentration need increase technology readiness level recovery considered priorities.

Language: Английский

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Single- vs. two-stage fermentation of an organic fraction of municipal solid waste for an enhanced medium chain carboxylic acids production − The impact of different pH and temperature

Bioresource Technology, Journal Year: 2024, Volume and Issue: unknown, P. 131697 - 131697

Published: Oct. 1, 2024

Language: Английский

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