Elsevier eBooks, Journal Year: 2022, Volume and Issue: unknown, P. 1 - 11
Published: Jan. 1, 2022
Language: Английский
Current Opinion in Psychology, Journal Year: 2020, Volume and Issue: 38, P. 49 - 55
Published: July 16, 2020
The aim of this review is to discuss the most recent evidence for short-term and long-term effects cannabis on cognition. that intoxication associated with impairment across several basal cognitive domains, including learning (episodic) memory, attentional control, motor inhibition increasing. However, regarding heavy use cognition remains equivocal. Cannabis research suffers from difficulties in measuring exposure history, poor control over potential subacute effects, heterogeneity measures sample composition. Multidisciplinary collaborations investment studies help overcome these should be prioritized.
Language: Английский
Citations
75
Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(7), P. 439 - 454
Published: May 27, 2021
Language: Английский
Citations
55
Stroke, Journal Year: 2022, Volume and Issue: 53(4)
Published: Feb. 10, 2022
Marijuana is perceived as a harmless drug, and its recreational use has gained popularity among young individuals. The concentration of active ingredients in formulations gradually increased over time, high-potency illicit cannabinomimetics have become available. Thus, the consumption cannabis general population rising. Data from preclinical models demonstrate that cannabinoid receptors are expressed high density areas involved cognition behavior, particularly during periods neurodevelopment maturation. In addition, growing evidence highlights role endogenous pathways regulation neurotransmitter release, synaptic plasticity, neurodevelopment. animal models, exogenous cannabinoids disrupt these important processes lead to cognitive behavioral abnormalities. These data correlate with higher risk impairment reported some observational studies done humans. It unclear whether effect on reverts after abstinence. However, this evidence, along stroke marijuana users, raises concerns about potential long-term effects function. This scientific statement reviews safety perspective brain health, describes mechanistically how may cause dysfunction, advocates for more informed health care worker consumer adversely affect brain.
Language: Английский
Citations
33
Frontiers in Neuroscience, Journal Year: 2021, Volume and Issue: 15
Published: Oct. 28, 2021
The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, plasticity circuit repair, up learning, memory, fear, protection, death. It a major player in the hypothalamic-peripheral system-adipose tissue regulation of food intake, energy storage, nutritional status, adipose mass, consequently affecting obesity. Loss control might affect mood disorders (anxiety, hyperactivity, psychosis, depression), lead drug abuse, impact neurodegenerative (Alzheimer’s, Parkinson, Huntington, Multiple, Amyotrophic Lateral Sclerosis) neurodevelopmental (autism spectrum) disorders. Practice regular physical and/or mind-body mindfulness meditative activities have been shown modulate (eCB) levels, addition other players as brain-derived neurotrophic factor (BDNF). involved pain, inflammation, metabolic cardiovascular dysfunctions, general immune responses (asthma, allergy, arthritis) tumor expansion, both/either periphery. reason for such vast fact that arachidonic acid, precursor eCBs, present every membrane cell body on demand eCBs synthesis regulated by electrical activity calcium shifts. Novel lipid (lipoxins resolvins) or peptide (hemopressin) also operate regulators physiological allostasis. Indeed, presence cannabinoid receptors intracellular organelles mitochondria lysosomes, nuclear targets PPARγ consumption, metabolism To live better life implies vigilant ECS, through healthy diet selection (based balanced omega-3 -6 polyunsaturated fatty acids), weekly exercises meditation therapy, all which regulating surrounded constructive social Cannabidiol, supplement has with anti-inflammatory, anxiolytic, antidepressant, antioxidant activities. Cognitive challenges emotional intelligence strengthen built variety synapses modify human behavior. As therapeutically concerned, essential maintaining cannabinoids are promising tools innumerous targets.
Language: Английский
Citations
33
npj Mental Health Research, Journal Year: 2025, Volume and Issue: 4(1)
Published: April 24, 2025
Abstract Posttraumatic stress disorder (PTSD) is associated with poor hippocampal function and disrupted pattern recognition. Cannabis use highly prevalent in individuals PTSD, yet the impact on these cognitive functions poorly understood. Participants ( n = 111) a range of PTSD symptoms without regular cannabis completed mnemonic similarity task. We hypothesized that would be alterations separation ability symptoms. High were reduced performance minimal users. Regular users high showed greater separation, but low These results suggest may disrupt similar hippocampal-dependent processes, while it improve cross-sectional require longitudinal follow-up studies to evaluate causal effects PTSD.
Language: Английский
Citations
0
Advances in pharmacology, Journal Year: 2022, Volume and Issue: unknown, P. 275 - 333
Published: Jan. 1, 2022
Language: Английский
Citations
15
Current Addiction Reports, Journal Year: 2024, Volume and Issue: 11(3), P. 384 - 395
Published: April 15, 2024
Language: Английский
Citations
3
Biological Psychiatry Global Open Science, Journal Year: 2022, Volume and Issue: 3(2), P. 222 - 232
Published: Feb. 8, 2022
We investigated how low marijuana (MJ) use levels, the typical pattern in most adolescent users, affect cognitive maturation and schizophrenia risk.
Language: Английский
Citations
13
Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12
Published: April 23, 2021
Cannabis (marijuana) has been known to humans for thousands of years but its neurophysiological effects were sparsely understood until recently. Preclinical and clinical studies in the past two decades have indisputably supported proposition that endocannabinoid system plays an important role etiopathogeneses many neuropsychiatric disorders, including mood addictive disorders. In this review, we discuss existing knowledge exo- endo-cannabinoids, depressive suicidal behavior. A dysfunction system, located brain regions such as prefrontal cortex limbic structures is implicated regulation, impulsivity decision-making, may increase risk negative cognition well suicidality. The literature discussed here also suggests be a viable target treatments these conditions.
Language: Английский
Citations
13
Comparative Clinical Pathology, Journal Year: 2022, Volume and Issue: 31(5), P. 853 - 873
Published: June 28, 2022
Language: Английский
Citations
9