The role of stress in the biological embedding of experience DOI Creative Commons
Robert Kumsta

Psychoneuroendocrinology, Journal Year: 2023, Volume and Issue: 156, P. 106364 - 106364

Published: Aug. 10, 2023

Exposure to early adversity is one of the most important and pervasive risk factors for development nearly all major mental disorders across lifespan. In search mediating mechanisms processes that underlie long-term stability these effects, changes stress-associated hormonal cellular signalling have emerged as prime candidates. This review summarises evidence showing experience in form childhood abuse or neglect exposure severe institutional deprivation influences multiple interconnected bio-behavioural, physiological processes. paper focusses on dysregulations stress regulation, altered DNA methylation pattern, transcriptomic profiles context stress-immune interplay, mitochondrial biology. Consistent findings include a relative cortisol hypoactivity hyporeactivity response challenge, increased activity pro-inflammatory genes, function. The majority investigations focussed single outcomes, but there clear rationale conceiving implicated parts wider regulatory network, which turn connected behaviour disorders. calls integrated longitudinal come more comprehensive understanding role biological embedding experience. concludes with considerations how research can contribute translational efforts through characterising subtypes arise function adversity, distinct features behavioral processing.

Language: Английский

Multi-omics in stress and health research: study designs that will drive the field forward DOI Creative Commons
Summer Mengelkoch, Jeffrey Gassen, Shahar Lev‐Ari

et al.

Stress, Journal Year: 2024, Volume and Issue: 27(1)

Published: Feb. 29, 2024

Despite decades of stress research, there still exist substantial gaps in our understanding how social, environmental, and biological factors interact combine with developmental stressor exposures, cognitive appraisals stressors, psychosocial coping processes to shape individuals' reactivity, health, disease risk. Relatively new profiling approaches, called multi-omics, are helping address these issues by enabling researchers quantify thousands molecules from a single blood or tissue sample, thus providing panoramic snapshot the molecular occurring an organism systems perspective. In this review, we summarize two types research designs for which multi-omics approaches best suited, describe can help advance development, prevention, treatment stress-related pathologies. We first discuss incorporating into theory-rich, intensive longitudinal study characterize, high-resolution, transition multisystem dysfunction throughout development. Next, should be incorporated intervention better understand back inform novel precision medicine managing fostering biopsychosocial resilience. Throughout, provide concrete recommendations studies that will translate data health care.

Language: Английский

Citations

11
Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues DOI Creative Commons

Robel Alemu,

Nigussie Tadesse Sharew,

Yodit Y. Arsano

et al.

Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 31, 2025

Non-communicable diseases (NCDs) such as cardiovascular diseases, chronic respiratory cancers, diabetes, and mental health disorders pose a significant global challenge, accounting for the majority of fatalities disability-adjusted life years worldwide. These arise from complex interactions between genetic, behavioral, environmental factors, necessitating thorough understanding these dynamics to identify effective diagnostic strategies interventions. Although recent advances in multi-omics technologies have greatly enhanced our ability explore interactions, several challenges remain. include inherent complexity heterogeneity multi-omic datasets, limitations analytical approaches, severe underrepresentation non-European genetic ancestries most omics which restricts generalizability findings exacerbates disparities. This scoping review evaluates landscape data related NCDs 2000 2024, focusing on advancements integration, translational applications, equity considerations. We highlight need standardized protocols, harmonized data-sharing policies, advanced approaches artificial intelligence/machine learning integrate study gene-environment interactions. also opportunities translating insights (GxE) research into precision medicine strategies. underscore potential advancing enhancing patient outcomes across diverse underserved populations, emphasizing fairness-centered strategic investments build local capacities underrepresented populations regions.

Language: Английский

Citations

1
Multi-omics approaches in psychoneuroimmunology and health research: Conceptual considerations and methodological recommendations DOI Open Access
Summer Mengelkoch, Sophia Miryam Schüssler‐Fiorenza Rose, Ziv Lautman

et al.

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 114, P. 475 - 487

Published: Aug. 4, 2023

Language: Английский

Citations

18
Multi-omics integration identifies regulatory factors underlying bovine subclinical mastitis DOI Creative Commons
Mengqi Wang,

Naisu Yang,

Mario Laterrière

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 14, 2024

Abstract Background Mastitis caused by multiple factors remains one of the most common and costly disease dairy industry. Multi-omics approaches enable comprehensive investigation complex interactions between layers information to provide a more holistic view pathogenesis. Therefore, this study investigated genomic epigenomic signatures possible regulatory mechanisms underlying subclinical mastitis integrating RNA sequencing data (mRNA lncRNA), small (miRNA) DNA methylation milk somatic cells from 10 healthy cows 20 with naturally occurring Staphylococcus aureus or chromogenes . Results Functional sets through gene set analysis uncovered 3458 biological process GO terms 170 KEGG pathways altered activities during mastitis, provided further insights into revealed involvement multi-omics in immune responses impaired mammary gland productivity mastitis. The abundant significant alterations related were observed, including 30,846, 2552, 1276 57 differential haplotype blocks (dMHBs), differentially expressed genes (DEGs), lncRNAs (DELs) miRNAs (DEMs), respectively. Next, 5 presenting principal variation identified. important roles Factor 1 (DEG, DEM DEL) 2 (dMHB DEM), regulation defense functions revealed. Each omics within Factors explained about 20% source Also, networks functional demonstrated, which contributed Furthermore, integration enabled association (dMHBs, DELs DEMs) pathways, such as ‘ infection pathway’ ‘natural killer cell mediated cytotoxicity pathway’, etc., provides mechanisms. Moreover, few (14 dMHBs, 25 DEGs, 18 identified candidate discriminant capacity distinguishing cows. Conclusion better understanding molecular for may ultimately lead development effective control management strategies.

Language: Английский

Citations

7
Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine DOI Creative Commons

Fabiola Stolfi,

Hugo Abreu,

Riccardo Sinella

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: June 13, 2024

Major depressive disorder (MDD) is a recurrent episodic mood that represents the third leading cause of disability worldwide. In MDD, several factors can simultaneously contribute to its development, which complicates diagnosis. According practical guidelines, antidepressants are first-line treatment for moderate severe major episodes. Traditional strategies often follow one-size-fits-all approach, resulting in suboptimal outcomes many patients who fail experience response or recovery and develop so-called “therapy-resistant depression”. The high biological clinical inter-variability within lack robust biomarkers hinder finding specific therapeutic targets, contributing failure rates. this frame, precision medicine, paradigm tailors medical interventions individual characteristics, would help allocate most adequate effective each patient while minimizing side effects. particular, multi-omic studies may unveil intricate interplays between genetic predispositions exposure environmental through study epigenomics, transcriptomics, proteomics, metabolomics, gut microbiomics, immunomics. integration flow information into molecular pathways produce better than current psychopharmacological targets singular mainly related monoamine systems, disregarding complex network our organism. concept system biomedicine involves analysis enormous datasets generated with different technologies, creating “patient fingerprint”, defines underlying mechanisms every patient. This review, centered on explores approaches as tools prediction MDD at single-patient level. It investigates how combining existing technologies used diagnostic, stratification, prognostic, treatment-response discovery artificial intelligence improve assessment MDD.

Language: Английский

Citations

6
The Legalome: Microbiology, Omics and Criminal Justice DOI Creative Commons
Alan C. Logan, Pragya Mishra, Susan L. Prescott

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(3)

Published: March 1, 2025

ABSTRACT Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles human cognition behaviour. Included this research is evidence indicating gut microbes, through direct indirect pathways, can influence aggression, anger, irritability antisocial Moreover, manufacture chemicals are known to compromise cognition. For example, recent court decisions United States Europe acknowledge produce high levels of ethanol, without consumption alcohol by defendants. The dismissal driving while intoxicated charges these cases—so‐called auto‐brewery syndrome—highlights way which microbiome knowledge will enhance precision, objectivity fairness our legal systems. Here opinion essay, we introduce concept ‘legalome’—the application science forensic psychiatry criminal law. We argue rapid pace microbial discoveries, including those challenge ideas free moral responsibility, necessitate a reconsideration traditional doctrines justifications retributive punishment. implications extend beyond courtroom, challenging us reconsider how environmental factors—from diet socioeconomic conditions—might shape preventative rehabilitative efforts their effects on microbiome.

Language: Английский

Citations

0
Efficacy and safety of fecal microbiota transplantation for chronic insomnia in adults: a real world study DOI Creative Commons
Haiming Fang, Tingting Yao, Wanli Li

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 21, 2023

Objective To assess the efficacy and safety of fecal microbiota transplantation (FMT) for adult chronic insomnia. Methods Patients treated with FMT diseases were divided into insomnia non-insomnia group. The primary endpoint was 4 weeks after treatment, secondary endpoints included impacts on anxiety, depression, health-related quality life, gut microbiota, adverse events associated FMT. Insomnia Severity Index (ISI) Pittsburgh Sleep Quality (PSQI) utilized to insomnia, self-rating anxiety/depression scale [Zung Self-Rating Anxiety Scale (SAS), Zung Depression (SDS)] employed evaluate anxiety depression. life evaluated by SF-36. 16S rRNA sequencing analyze correlation analysis performed. Results Forty patients met inclusion criteria seven excluded. 33 enrolled stratified group ( N = 17) 16). Compared baseline, significantly ameliorated ISI (17.31 ± 5.12 vs. 5.38 5.99), PSQI (14.56 2.13 6.63 4.67), SAS (54.25 8.90 43.68 10.64) SDS (57.43 10.96 50.68 15.27) score patients. 76.47% (13/17) achieved endpoints. In patients, relative abundance Eggerthella marked enhanced at while Lactobacillus, Bifidobacterium, Turicibacter, Anaerostipes , Eisenbergiella increased latter positive correlated Encouragingly, also improved sleep Conclusion may potentially serve as a distinctive genus maybe novel treatment option adults provide an alternative traditional treatments effects augmentation probiotics, such Bifidobacterium Lactobacillus Turicibacter Fusobacterium .

Language: Английский

Citations

12
Comprehensive multi-omics analysis reveals the mechanism of hepatotoxicity induced by Emilia sonchifolia (L.) DC DOI
Xin Liu,

Gongzhen Chen,

Yuqi Yang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119371 - 119371

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multi-omics and drug development DOI

Saira Hamid,

Ajaz A. Bhat,

Muzafar Rasool Bhat

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 147 - 171

Published: Jan. 1, 2025

Citations

0
A comprehensive review of neurotransmitter modulation via artificial intelligence: A new frontier in personalized neurobiochemistry DOI

Jaleh Bagheri Hamzyan Olia,

Arasu Raman, Chou‐Yi Hsu

et al.

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 189, P. 109984 - 109984

Published: March 14, 2025

Language: Английский

Citations

0