Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 354, P. 318 - 320
Published: March 11, 2024
Language: Английский
Psychological Medicine, Journal Year: 2025, Volume and Issue: 55
Published: Jan. 1, 2025
Abstract Background Offspring of parents with bipolar disorder (BD offspring) face elevated risks for emotional dysregulation and cognitive deficits, particularly in working memory. This study investigates memory deficits their neural correlates BD offspring. Methods We assessed 41 offspring 25 age-matched healthy controls (HCs) using a spatial N-back task task-related functional magnetic resonance imaging (fMRI). Results Compared to HCs, exhibit reduced accuracy lower signal-detection sensitivity ( d ′) on the 1-back task. fMRI reveals hyperactivation right intracalcarine cortex/lingual gyrus (ICC/LG) offspring, during condition. Psychophysiological interaction (PPI) analyses show connectivity between ICC/LG left postcentral as load increases from 0-back 1-back. positively performance HCs but not Additionally, bilateral dorsolateral prefrontal cortex (DLPFC) regions interest, PPI diminished condition-dependent DLPFC superior frontal gyrus/paracingulate cortex, gyrus/precentral increases. Conclusions These findings suggest that impaired involving both sensory processing higher-order systems. Such may emerge at genetically predisposed stage disorder, underscoring significance early identification intervention strategies.
Language: Английский
Citations
0
Neuropsychiatric Disease and Treatment, Journal Year: 2023, Volume and Issue: Volume 19, P. 2617 - 2626
Published: Nov. 1, 2023
Abstract: Bipolar disorder (BD) is a common and highly heritable psychiatric disorder, the study of BD genetic characteristics can help with early prevention individualized treatment. At same time, heterogeneous polygenic significant overlap other disorders. In recent years, risk scores (PRS) derived from genome-wide association studies (GWAS) data have been widely used in various complex diseases be to explore susceptibility diseases. This review discusses phenotypic associations correlations conditions based on PRS, provides ideas for BD. Keywords: bipolar scores, forecast
Language: Английский
Citations
5
Psychological Medicine, Journal Year: 2024, Volume and Issue: 54(11), P. 2857 - 2865
Published: April 18, 2024
Abstract Background There is a significant contribution of genetic factors to the etiology bipolar disorder (BD). Unaffected first-degree relatives patients (UR) with BD are at increased risk developing mental disorders and may manifest cognitive impairments alterations in brain functional connective dynamics, akin their affected relatives. Methods In this prospective longitudinal study, resting-state connectivity was used explore stable progressive markers vulnerability i.e. abnormalities shared between UR compared healthy controls (HC) resilience features unique HC full or partial remission (UR n = 72, mean age 28.0 ± 7.2 years; 64, 30.0 9.7 91, 30.6 7.7 years). Out these, 34 UR, 48 BD, 38 were investigated again following time 1.3 0.4 years. Results At baseline, showed lower values within default mode network (DMN), frontoparietal network, salience (SN) HC. This pattern remained over follow-up period not present suggesting trait. The further demonstrated less negative DMN SN HC, abnormality that also marker. Conclusion Our findings indicate coexistence both vulnerability-related connectivity, as well adaptive changes possibly promoting psychopathology individual familial risk.
Language: Английский
Citations
1
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 369, P. 845 - 853
Published: Oct. 18, 2024
Language: Английский
Citations
1
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 354, P. 318 - 320
Published: March 11, 2024
Language: Английский
Citations
0