Substance P’s Impact on Chronic Pain and Psychiatric Conditions—A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5905 - 5905

Published: May 28, 2024

Substance P (SP) plays a crucial role in pain modulation, with significant implications for major depressive disorder (MDD), anxiety disorders, and post-traumatic stress (PTSD). Elevated SP levels are linked to heightened sensitivity various psychiatric conditions, spurring interest potential therapeutic interventions. In chronic pain, commonly associated MDD emerges as key mediator emotional regulation. This review examines SP’s impact on perception its contributions MDD, PTSD. The association of increased conditions underscores importance modulation. Additionally, influences the pathophysiology PTSD, highlighting target. Understanding diverse effects provides valuable insights into mechanisms underlying these disorders their treatment. Further research is essential explore modulation develop more effective treatment strategies.

Language: Английский

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GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Sept. 24, 2024

The microcircuitry within superficial layers of the dorsolateral prefrontal cortex (DLPFC), composed excitatory pyramidal neurons and inhibitory GABAergic interneurons, has been suggested as neural substrate working memory performance. In schizophrenia, impairments are thought to result from alterations DLPFC. in particular, crucially involved synchronizing activity at gamma frequency, power which increases with load. Alterations particularly parvalbumin (PV) somatostatin (SST) subtypes, frequently observed schizophrenia. Abnormalities neurotransmission, such deficiencies 67 kDA isoform GABA synthesis enzyme (GAD67), vesicular transporter (vGAT), reuptake 1 (GAT1) presynaptic boutons, well postsynaptic A receptor subunits further contribute impaired inhibition. This review explores abnormalities postmortem DLPFC a focus on roles interneuron subtypes cognition, neurotransmission boutons alterations. Where available, comparisons between schizophrenia affective disorders that share cognitive pathology bipolar disorder major depressive will be made. Challenges directly measuring levels addressed, emphasizing need for innovative techniques. Understanding their implications circuit dysfunction is crucial developing targeted therapies.

Language: Английский

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Cholecystokinin in the central and peripheral nervous system

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 101 - 160

Published: Jan. 1, 2025

Language: Английский

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Long Neuro-COVID-19: Current Mechanistic Views and Therapeutic Perspectives

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1081 - 1081

Published: Aug. 28, 2024

Long-lasting COVID-19 (long COVID) diseases constitute a real life-changing burden for many patients around the globe and, overall, can be considered societal and economic issues. They include variety of symptoms, such as fatigue, loss smell (anosmia), neurological–cognitive sequelae, memory loss, anxiety, brain fog, acute encephalitis, stroke, collectively called long neuro-COVID-19 neuro-COVID). also cardiopulmonary myocardial infarction, pulmonary damage, fibrosis, gastrointestinal dysregulation, renal failure, vascular endothelial onset new diabetes, with each symptom usually being treated individually. The main unmet challenge is to understand mechanisms pathophysiologic in particular neurological symptoms. This mini-review presents mechanistic hypotheses explain multiple neuro-COVID namely immune dysregulation prolonged inflammation, persistent viral reservoirs, dysfunction, disruption neurotransmitter signaling along various paths. We suggest that nucleoprotein N SARS-CoV-2 constitutes “hub” between virus host immunity, neurotransmission.

Language: Английский

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Of artificial intelligence, machine learning, and the human brain. Celebrating Miklos Palkovits' 90th birthday

Frontiers in Neuroanatomy, Journal Year: 2024, Volume and Issue: 18

Published: May 3, 2024

OPINION article Front. Neuroanat., 03 May 2024 Volume 18 - | https://doi.org/10.3389/fnana.2024.1374864

Language: Английский

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Role of the locus coeruleus-noradrenergic system in stress-related psychopathology and resilience: clinical and pre-clinical evidences

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 167, P. 105925 - 105925

Published: Oct. 18, 2024

Language: Английский

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