Functional Hydrogels as Wound Dressing to Enhance Wound Healing

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12687 - 12722

Published: Aug. 10, 2021

Hydrogels, due to their excellent biochemical and mechnical property, have shown attractive advantages in the field of wound dressings. However, a comprehensive review functional hydrogel as dressing is still lacking. This work first summarizes skin healing process relates evaluation parameters then reviews advanced functions dressings such antimicrobial adhesion hemostasis, anti-inflammatory anti-oxidation, substance delivery, self-healing, stimulus response, conductivity, recently emerged monitoring feature, strategies adopted achieve these are all classified discussed. Furthermore, applications for treatment different types wounds incisional excisional summarized. Chronic also mentioned, focus attention on infected wounds, burn diabetic Finally, future directions further proposed.

Language: Английский

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Translational Applications of Hydrogels

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(18), P. 11385 - 11457

Published: May 3, 2021

Advances in hydrogel technology have unlocked unique and valuable capabilities that are being applied to a diverse set of translational applications. Hydrogels perform functions relevant range biomedical purposes-they can deliver drugs or cells, regenerate hard soft tissues, adhere wet prevent bleeding, provide contrast during imaging, protect tissues organs radiotherapy, improve the biocompatibility medical implants. These make hydrogels useful for many distinct pressing diseases conditions even less conventional areas such as environmental engineering. In this review, we cover major hydrogels, with focus on novel benefits injectable how they relate applications medicine environment. We pay close attention development contemporary requires extensive interdisciplinary collaboration accomplish highly specific complex biological tasks from cancer immunotherapy tissue engineering vaccination. complement our discussion preclinical clinical mechanical design considerations needed scaling technologies application. anticipate readers will gain more complete picture expansive possibilities practical impactful differences across numerous fields

Language: Английский

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Rational design and latest advances of polysaccharide-based hydrogels for wound healing

Biomaterials Science, Journal Year: 2020, Volume and Issue: 8(8), P. 2084 - 2101

Published: Jan. 1, 2020

This review presented the crucial design considerations and current state of polysaccharide-based hydrogels as wound dressings. The commonly used crosslinking techniques are also discussed in detail.

Language: Английский

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Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications

Biomacromolecules, Journal Year: 2020, Volume and Issue: 21(5), P. 1802 - 1811

Published: Jan. 22, 2020

Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending proprietary wound dressings. Recently, silver nanoparticles have attracted attention in management. In current study, green synthesis was accomplished using reducing agent, curcumin, which polyphenolic compound that well-known as wound-healing agent. The hydrophobicity curcumin overcome by its microencapsulation cyclodextrins. This study demonstrates production, characterization aqueous curcumin:hydroxypropyl-β-cyclodextrin complex loading them into bacterial cellulose hydrogel moist properties. These nanoparticle-loaded hydrogels were characterized for wound-management applications. addition cytocompatibility, these novel dressings exhibited activity against three common wound-infecting pathogenic microbes Staphylococcus aureus, Pseudomonas aeruginosa, Candida auris.

Language: Английский

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Research status of self-healing hydrogel for wound management: A review

International Journal of Biological Macromolecules, Journal Year: 2020, Volume and Issue: 164, P. 2108 - 2123

Published: Aug. 13, 2020

Language: Английский

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A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(9), P. 2829 - 2840

Published: Feb. 21, 2021

In recent years, the developed hemostatic technologies are still difficult to be applied hemostasis of massive arterial and visceral hemorrhage, owing their weak function, inferior wet tissue adhesion, low mechanical properties. Herein, a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust property (308.47 ± 29.20 kPa) excellent efficiency (96.5% 2.1%) was constructed as sealant. Typically, we combined chitosan (CS) silk fibroin (SF) by cross-linking them through tannic acid (TA) maintain structural stability hydrogel, especially for adhesion ability (shear adhesive strength = 29.66 0.36 kPa). Compared other materials reported previously, obtained CS/TA/SF yielded lower amount blood loss shorter time in various bleeding models, which could ascribed synergistic effect wound closure under state well intrinsic activity CS. As superior sealant, unique proposed this work can exploited offer significant advantages acute hemorrhage restrictive access therapeutic moieties.

Language: Английский

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Injectable Adhesive Self-Healing Multicross-Linked Double-Network Hydrogel Facilitates Full-Thickness Skin Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2020, Volume and Issue: 12(52), P. 57782 - 57797

Published: Dec. 18, 2020

The development of natural polymer-based hydrogels, combining outstanding injectability, self-healing, and tissue adhesion, with mechanical performance, able to facilitate full-thickness skin wound healing, remains challenging. We have developed an injectable micellar hydrogel (AF127/HA-ADH/OHA-Dop) adhesive self-healing properties accelerate healing. Dopamine-functionalized oxidized hyaluronic acid (OHA-Dop), adipic dihydrazide-modified HA (HA-ADH), aldehyde-terminated Pluronic F127 (AF127) were employed as polymer backbones. They cross-linked in situ using Schiff base dynamic covalent bonds (AF127 micelle/HA-ADH network HA-ADH/OHA-Dop network), hydrogen bonding, π–π stacking interactions. resulting multicross-linked double-network design forms a hydrogel. unique structure endows the both improved injection abilities performance while faster than single-network hydrogels. Inspired by mussel foot protein, OHA-Dop mimics catechol groups seen proteins, endowing hydrogels robust adhesion properties. also demonstrate potential our cutaneous closure improve regeneration reduced scarring. anticipate that platform based on novel will transform future multifunctional dressings.

Language: Английский

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Structural and biological engineering of 3D hydrogels for wound healing

Bioactive Materials, Journal Year: 2022, Volume and Issue: 24, P. 197 - 235

Published: Dec. 23, 2022

Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause death worldwide. Wound dressings necessary to facilitate wound treatment. Engineering may substantially reduce healing time, risk recurrent infections, disability costs associated. In path engineering an ideal dressing, hydrogels played role. Hydrogels 3D hydrophilic polymeric structures that can provide protective barrier, mimic native extracellular matrix (ECM), humid environment. Due their advantages, (with different architectural, physical, mechanical, biological properties) been extensively explored as dressing platforms. Here we describe recent studies on applications with strong focus interplay between fabrication method used performance achieved. Moreover, review categories additives which enhance regeneration using hydrogel dressings. Hydrogel promises generation smart solutions solve this pressing problem, enabling key functionalities such bacterial growth inhibition, enhanced re-epithelialization, vascularization, improved recovery tissue functionality, overall, accelerated effective healing.

Language: Английский

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Recent advances in polysaccharide-based self-healing hydrogels for biomedical applications

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 283, P. 119161 - 119161

Published: Jan. 25, 2022

Language: Английский

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Physically cross-linked chitosan-based hydrogels for tissue engineering applications: A state-of-the-art review

European Polymer Journal, Journal Year: 2021, Volume and Issue: 145, P. 110176 - 110176

Published: Jan. 17, 2021

Language: Английский

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