Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4962 - 4962
Published: March 4, 2023
Wound
healing
is
a
complex
process
of
overlapping
phases
with
the
primary
aim
creation
new
tissues
and
restoring
their
anatomical
functions.
dressings
are
fabricated
to
protect
wound
accelerate
process.
Biomaterials
used
design
dressing
wounds
could
be
natural
or
synthetic
as
well
combination
both
materials.
Polysaccharide
polymers
have
been
fabricate
dressings.
The
applications
biopolymers,
such
chitin,
gelatin,
pullulan,
chitosan,
greatly
expanded
in
biomedical
field
due
non-toxic,
antibacterial,
biocompatible,
hemostatic,
nonimmunogenic
properties.
Most
these
form
foams,
films,
sponges,
fibers
drug
carrier
devices,
skin
tissue
scaffolds,
Currently,
special
focus
has
directed
towards
fabrication
based
on
synthesized
hydrogels
using
polymers.
high-water
retention
capacity
makes
them
potent
candidates
for
they
provide
moist
environment
remove
excess
fluid,
thereby
accelerating
healing.
incorporation
pullulan
different,
naturally
occurring
polymers,
currently
attracting
much
attention
antimicrobial,
antioxidant
Despite
valuable
properties
it
also
some
limitations,
poor
mechanical
high
cost.
However,
improved
by
blending
different
Additionally,
more
investigations
required
obtain
derivatives
suitable
quality
engineering
applications.
This
review
summarizes
then
examines
other
biocompatible
chitosan
discusses
facile
approaches
oxidative
modification
pullulan.
Biomaterials,
Journal Year:
2024,
Volume and Issue:
312, P. 122718 - 122718
Published: July 27, 2024
Functional
hydrogels
are
used
for
numerous
biomedical
applications
such
as
tissue
engineering,
wound
dressings,
lubricants,
contact
lenses
and
advanced
drug
delivery
systems.
Most
of
them
based
on
synthetic
or
natural
polymers
forming
a
three-dimensional
network
that
contains
aqueous
media.
Among
polymers,
poly(meth)acrylates,
polyethyleneglycols,
poly(vinylalcohols),
poly(vinylpyrrolidones),
PLGA
poly(urethanes)
high
relevance,
whereas
mainly
polysaccharides
hyaluronic
acid,
alginate
chitosan
proteins
albumin,
collagen
elastin.
In
contrast
to
most
biodegradable.
Both
often
chemically
modified
in
order
improve
induce
favorable
properties
functions
like
mechanical
strength,
stiffness,
elasticity,
porosity,
adhesive
properties,
situ
gelling
water
binding
capacity
release
controlling
properties.
Within
this
review
we
provide
an
overview
about
the
broad
spectrum
functional
hydrogels,
summarize
innovative
approaches,
discuss
concept
relevant
clinical
trials
highlight
products
examples
successful
developments.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
