A pH-Responsive Ti-Based Local Drug Delivery System for Osteosarcoma Therapy DOI Creative Commons
Qin Xiao, Changjun Wan, Zhe Zhang

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(10), P. 312 - 312

Published: Oct. 21, 2024

Osteosarcoma is one of the major bone cancers, especially for youngsters. The current treatment usually requires systemic chemotherapy and removal tumors. Titanium (Ti)-based implants can be modified as local drug delivery (LDD) systems controllable localized chemotherapeutic release. In this work, a pH-responsive Ti-based LDD prototype was designed by introducing polydopamine (PDA) to release doxorubicin (DOX) around osteosarcoma cells with low pH. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle meter were applied surface characterization. Both direct indirect cell culture modes performed biocompatibility biofunction assessments. results indicate that exhibits significant pH-dependent DOX cumulative reach up approximately 40% at pH = 6.0 after 72 h, but only 20% 7.4. implant shows good 93% viability MC3T3 in vitro 24 h. verify anti-osteosarcoma function implant, which should attributed DOX.

Language: Английский

Bioactive chitosan/polydopamine nanospheres coating on carbon fiber towards strengthening epoxy composites DOI
Qing Wu,

Bolin Xiao,

Yating Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133568 - 133568

Published: July 3, 2024

Language: Английский

Citations

9
Near-Infrared Multifunctional Antitumor Nanomaterial of Bismuth Sulfide Heterojunction Coupled with Mesoporous Polydopamine DOI

Juanxuan Guo,

Biling Chen,

Menglong Zhao

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Bismuth sulfide@bismuth nanorods (Bi2S3@Bi NRs) have emerged as promising photodynamic therapeutic agents due to Bi2S3@Bi being able produce reactive oxygen species from self-supplied O2. Combining photothermal and therapies with chemotherapy is attractive but difficult achieve. Here, we develop a subtle method wrap NRs mesoporous polydopamine, where drug doxorubicin hydrochloride can be loaded, thus providing multifunctional antitumor nanospheres. To our delight, the prepared triple-functional material exhibits excellent efficacy toward tumor cells under near-infrared light irradiation. This nanomaterial not only biocompatible also suitable for hypoxic microenvironments, having much better than single- or double-functional materials. study highlights great potential of combining photothermal, photodynamic, chemotherapies.

Language: Английский

Citations

0
Tannic acid/doxorubicin hybrid nano-assemblies decorated with D-α-tocopheryl polyethylene glycol succinate-conjugated pemetrexed to treat non-small cell lung cancer DOI

Wei-Jen Huang,

Wen‐Hsuan Chiang,

Hsiang-Yun Chih

et al.

Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2025, Volume and Issue: 172, P. 106115 - 106115

Published: April 8, 2025

Language: Английский

Citations

0
Enhanced Intracellular IR780 Delivery by Acidity-Triggered PEG-Detachable Hybrid Nanoparticles to Augment Photodynamic and Photothermal Combination Therapy for Melanoma Treatment DOI Creative Commons

Min‐Chen Tsai,

L. T. Hsiao,

Yen-Hsuan Chang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

The PEGylation of drug-carrying nanoparticles has often been used to prolong blood circulation and improve drug deposition at tumor sites. Nevertheless, the PEG-rich hydrophilic surfaces retard release payloads internalization therapeutic by cancer cells, thus lowering anticancer efficacy. To boost potency combined photodynamic therapy (PDT) photothermal (PTT) against melanoma conquering PEG dilemma, herein, hybrid PEGylated chitosan-covered polydopamine (PDA) (PCPNs) with acidity-elicited detachment ability were fabricated as carriers IR780, a small-molecule photosensitizer for PTT PDT. IR780@PCPNs displayed uniform, solid-like spherical shape sound colloidal stability. Under near-infrared (NIR) irradiation, showed prominent conversion efficiency (ca. 54.6%), robust stability, reduced IR780 photobleaching, sufficient singlet oxygen (1O2) production, glutathione-depleting ability. Moreover, environmental pH being from 7.4 5.0 37 °C, decreased interactions between PCPNs due increased protonation phenolic hydroxyl residues within PDA primary amine groups chitosan accelerated species IR780@PCPNs. Importantly, cellular uptake B16F10 was remarkably promoted in weakly acidic milieu upon driven disintegration acid-labile benzoic imine. With NIR internalized generated hyperthermia 1O2 damage mitochondria, thereby effectively inhibiting proliferation cells. Collectively, our findings present practical strategy amplifying efficacy PDT using PEG-detachable

Language: Английский

Citations

0
Construction of CuS/HKUST-1@PDA drug carrier for enhanced chemo-photothermal synergistic therapy triggered by near-infrared light in tumor treatment DOI

Peixuan Zou,

Yusong Pan, Wenjie Luo

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114784 - 114784

Published: May 1, 2025

Language: Английский

Citations

0
RGD peptide-conjugated polydopamine nanoparticles loaded with doxorubicin for combined chemotherapy and photothermal therapy in thyroid cancer DOI Creative Commons

Donglan Yuan,

Zhiqiang Lu,

Xin-Rong Xu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

To construct polydopamine (PDA)-based nanoparticles (NPs) for combined chemotherapy (CT) and photothermal therapy (PTT) of thyroid tumors by conjugating doxorubicin (DOX) via Schiff base reaction decorating with RGD peptide.

Language: Английский

Citations

1
A pH-Responsive Ti-Based Local Drug Delivery System for Osteosarcoma Therapy DOI Creative Commons
Qin Xiao, Changjun Wan, Zhe Zhang

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(10), P. 312 - 312

Published: Oct. 21, 2024

Osteosarcoma is one of the major bone cancers, especially for youngsters. The current treatment usually requires systemic chemotherapy and removal tumors. Titanium (Ti)-based implants can be modified as local drug delivery (LDD) systems controllable localized chemotherapeutic release. In this work, a pH-responsive Ti-based LDD prototype was designed by introducing polydopamine (PDA) to release doxorubicin (DOX) around osteosarcoma cells with low pH. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle meter were applied surface characterization. Both direct indirect cell culture modes performed biocompatibility biofunction assessments. results indicate that exhibits significant pH-dependent DOX cumulative reach up approximately 40% at pH = 6.0 after 72 h, but only 20% 7.4. implant shows good 93% viability MC3T3 in vitro 24 h. verify anti-osteosarcoma function implant, which should attributed DOX.

Language: Английский

Citations

0