Symmetry,
Journal Year:
2024,
Volume and Issue:
16(1), P. 73 - 73
Published: Jan. 5, 2024
This
paper
presents
the
general
synthesis
of
a
comprehensive
group
P-chiral
phosphinyl
derivatives
with
natural
coumarin-type
motif.
A
chiral
substituent
was
attached
at
third
position
coumarin
molecule
via
Knoevenagel
procedure
using
readily
available
phoshinylacetic
acid
esters
without
loss
enantiomeric
purity.
The
application
salicylaldehyde-based
allowed
incorporation
substituents
different
electron
character
into
backbone
these
coumarins
making
them
suitable
for
subsequent
chemical
modifications.
As
result,
we
gained
access
to
six
achiral
(2a–g)
and
large
number
((Sp)-4a–f,
(Sp)-6a–e
(Rp)-8a)
new
potential
ligand
precursors,
pharmaceuticals,
etc.
an
imbedded
evidenced
biological
activity
based
on
backbone.
molecular
structure,
including
absolute
configuration,
determined
seven
compounds.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
The
advent
of
bioorthogonal
chemistry
has
transformed
scientific
research,
offering
a
powerful
tool
for
selective
and
noninvasive
labeling
(bio)molecules
within
complex
biological
environments.
This
innovative
approach
facilitated
the
study
intricate
cellular
processes,
protein
dynamics,
interactions.
Nevertheless,
number
challenges
remain
to
be
addressed,
including
need
improved
reaction
kinetics,
enhanced
biocompatibility,
development
more
diverse
orthogonal
set
reactions.
While
scientists
continue
search
veritable
solutions,
remains
transformative
with
vast
potential
advancing
our
understanding
biology
medicine.
Perspective
offers
insights
into
reactions
commonly
classified
as
"bioorthogonal",
which,
however,
may
not
always
demonstrate
desired
selectivity
regarding
interactions
between
their
components
additives
or
catalysts
used
under
conditions.
Journal of Materials Chemistry A,
Journal Year:
2023,
Volume and Issue:
11(48), P. 26371 - 26392
Published: Jan. 1, 2023
Detection
and
sensing
of
lithium
ions
are
very
important
in
chemical,
environmental,
biological
processes.
Photochemical
sensors
including
fluorescent
compounds
have
been
used
as
smart
systems
to
detect
sense
ions.
Current Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
28(15), P. 1179 - 1189
Published: May 23, 2024
Abstract:
Photoresponsive
polymers
have
emerged
as
innovative
tools
in
the
domain
of
drug
delivery,
presenting
advanced
solutions
for
controlled
and
targeted
release
therapeutic
agents.
This
review
explores
recent
advances
design
application
photoresponsive
polymers,
focusing
on
their
pivotal
role
light-triggered
delivery
systems.
It
also
encompasses
organic
synthesis
methodologies,
key
advancements
polymer
design,
integration
elements
into
carriers.
Moreover,
this
focuses
applications,
challenges,
future
prospects,
providing
a
comprehensive
overview
evolving
landscape
light-responsive
technologies.
The
information
about
presented
herein
aims
to
contribute
understanding
advancement
dynamic
field,
offering
insights
researchers
practitioners
engaged
development
next-generation
Macromolecules,
Journal Year:
2024,
Volume and Issue:
57(12), P. 5915 - 5928
Published: June 4, 2024
Stimuli-responsive
helical
polymers
form
an
intriguing
class
of
materials
that
may
find
broad
applications
in
chiroptical
or
switchable
chiral
devices.
Here
we
report
the
synthesis
a
dendronized
copolymers
with
poly(phenylacetylene)
(PPA)
backbones.
These
carry
methoxy-terminated
dendritic
oligoethylene
glycol
(OEG)
pendants
and
spiropyran
moieties.
Both
block
random
were
prepared
to
investigate
effect
structure
on
their
stimuli-responsiveness
helicities,
as
well
supramolecular
assemblies
aqueous
conditions.
The
exhibited
typical
thermoresponsive
behavior
through
thermal
dehydration
OEGs
tunable
cloud
point
temperatures
(Tcps).
Polarity
differences
between
hydrophilic
OEG
lipophilic
PPA
backbones
afforded
all
radial
amphiphilicity.
In
addition,
for
copolymers,
polarity
SP
further
provided
axial
Their
unprecedented
amphiphilic
nature
drove
preferentially
aggregate
water
even
below
Tcps.
On
heating
across
Tcps,
thermally
induced
phase
transitions
resulted
switches
helicity.
Photoisomerization
moieties
closed
spirocyclic
(SP)
open
merocyanine
(MC)
within
copolymer
matrices
was
dependent
balance
interactions
OEGs,
which
did
not
exhibit
obvious
influence
helicities.
Supramolecular
assembly
tend
extremely
long
fibers
thicknesses
about
25
nm,
while
anisotropic
nanocubes
dimensions
around
400–600
nm
observed
from
indicating
topology
plays
important
role
modulating
assemblies.
