Published: Jan. 1, 2024
Language: Английский
Advanced Engineering Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
It has been more than two decades since laser‐induced forward transfer (LIFT) was studied on a laboratory scale for its ability to print biomaterials. Most of the published works in this field are focused use nanosecond lasers. Our final objective is LIFT technique picosecond regime create vitro biomodels tissue engineering and regenerative medicine applications. But first approach, work presented here focuses hydrodynamics rheological studies optimization process bioapplications. In order precisely control amount position deposited material, it necessary carefully investigate jetting dynamics as function various parameters, including laser fluence properties bioink. study, time‐resolved fast imaging used successive jets at high pulse repetition rate. Different conditions have determined (bioink viscosity, specific dynamic associated with precise distance printing, parameters) quantity ink number cells per droplet accuracy their location good reproducibility printing process.
Language: Английский
Citations
0
Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00407 - e00407
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16
Published: April 28, 2025
Stem cell research has significantly transformed regenerative medicine, with pluripotent stem cells (PSCs) serving as the cornerstone for disease modeling, drug screening, and therapeutic applications. Embryonic (ESCs) exhibit unparalleled self-renewal tri-lineage differentiation, while induced (iPSCs) bypass ethical constraints through somatic reprogramming. Clinical trials highlight potential of mesenchymal (MSCs) in osteoarthritis graft-versus-host disease, which leverage their immunomodulatory paracrine effects. Despite advancements, challenges persist: iPSCs face epigenetic instability tumorigenic risks, adult struggle inefficient differentiation. This paper systematically reviews source classification, differentiation regulatory mechanisms, cutting-edge technologies such CRISPR/Cas9, explores field-specific controversies (e.g., stability iPSCs) future directions integration organoids biomaterials). By analyzing current progress challenges, it provides a multidimensional perspective research.
Language: Английский
Citations
0
Biomimetics, Journal Year: 2024, Volume and Issue: 9(12), P. 733 - 733
Published: Dec. 1, 2024
Three-dimensional bioprinting (3DP) is transforming the field of regenerative medicine by enabling precise fabrication complex tissues, including retina, a highly specialized and anatomically tissue. This review provides an overview 3DP’s principles, its multi-step process, various techniques, such as extrusion-, droplet-, laser-based methods. Within scope biomimicry biomimetics, emphasis placed on how 3DP potentially enables recreation retina’s natural cellular environment, structural complexity, biomechanical properties. Focusing retinal tissue engineering, we discuss unique challenges posed layered structure, vascularization needs, interplay between numerous cell types. Emphasis recent advancements in bioink formulations, designed to emulate characteristics improve viability, printability, mechanical stability. In-depth analyses bioinks, scaffold materials, emerging technologies, microfluidics organ-on-a-chip, highlight potential bioprinted models replicate disease states, facilitating drug development testing. While remain achieving clinical translation—particularly immune compatibility long-term integration—continued innovations bioinks scaffolding are paving way toward functional constructs. We conclude with insights into future research directions, aiming refine for personalized therapies transformative applications vision restoration.
Language: Английский
Citations
1
Published: Jan. 1, 2024
Language: Английский
Citations
0