Chitosan microporous foam filled 3D printed polylactic acid-pearl macroporous scaffold: Dual-scale porous structure, biological and mechanical properties

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140508 - 140508

Published: Jan. 1, 2025

Language: Английский

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Dual-functional Hydroxyapatite scaffolds for bone regeneration and precision drug delivery

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2024, Volume and Issue: 157, P. 106661 - 106661

Published: July 14, 2024

Language: Английский

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Unveiling the potential of pullulan in enhancing ketoprofen release from PHBV filaments

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139421 - 139421

Published: Jan. 2, 2025

Language: Английский

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Recent Advances and Challenges for Biological Materials in Micro/Nanocarrier Synthesis for Bone Infection and Tissue Engineering

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.

Language: Английский

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Transcriptomic Profile of Human Osteoblast-like Cells Grown on Trabecular Titanium

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3598 - 3598

Published: April 11, 2025

Trabecular titanium implants are widely used in orthopedic surgery and known to promote osseointegration. In this study, we investigated whether primary human osteoblast-like cells grown inside a 3D trabecular scaffold undergo changes migration capacity, transcriptomic profile, cellular phenotype as compared the same osteoblasts not scaffold. Scratch tests have shown that of from external environment into Next generation sequencing analysis demonstrated modified expression genes involved cell cycle extracellular matrix remodeling, while maintaining normal specific osteoblast markers, such osteocalcin osterix, well comparable mineralization capacity. These data demonstrate acquire features favoring

Language: Английский

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Mechanical Properties and Decomposition Behavior of Compression Moldable Poly(Malic Acid)/α-Tricalcium Phosphate Hybrid Materials

Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 147 - 147

Published: Jan. 9, 2025

Calcified tissues in living organisms, such as bone, dentin, and enamel, often require surgical intervention for treatment. However, advances regenerative medicine have increased the demand materials to assist regenerating these tissues. Among various forms of calcium phosphate (CaP), tricalcium (TCP)-particularly its α-TCP form-stands out due high solubility efficient release, making it a promising candidate bone regeneration applications. Nevertheless, rapid dissolution rate presents challenges when used reinforcing agent. In this study, we developed hybrid material composed poly(malic acid) (PMA) achieve controlled release while maintaining mechanical strength. The were prepared using compression molding method optimized suppress hydrolysis PMA. bond between carboxyl group PMA was confirmed through infrared (IR) spectroscopy. A test demonstrated that interaction extends period both components. These findings indicate PMA/α-TCP significant potential applications tissue engineering.

Language: Английский

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Bioinspired PCL-Based Composite Scaffolds Produced via Hot Melt Extrusion and Fused Filament Fabrication: An Integrated Workflow for Enhanced Bone Regeneration

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106679 - 106679

Published: Feb. 1, 2025

Language: Английский

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Mechanical and fatigue performance of multidirectional functionally graded Ti6Al4V scaffolds produced via laser powder bed fusion for orthopedic implants

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113725 - 113725

Published: Feb. 1, 2025

Language: Английский

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Contemporary Advances in Diagnosis, Management, and Prevention of Traumatic Dental Injuries

Dentistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Traumatic dental injuries (TDIs) represent a significant global healthcare challenge, affecting different age groups and socioeconomic strata. This comprehensive chapter presents contemporary advances in diagnosing, managing, preventing TDIs, integrating evidence-based approaches with emerging technologies biological interventions. The text systematically addresses the multifaceted nature of trauma, from immediate emergency response to long-term rehabilitation, while considering broader implications for systems society. Recent developments diagnostic technologies, including artificial intelligence-assisted imaging advanced assessment tools, have transformed initial evaluation trauma. explores innovative treatment modalities, encompassing regenerative endodontics, stem cell applications, computer-guided interventions alongside traditional approaches. Particular emphasis is placed on digital workflows, teledentistry minimally invasive techniques that revolutionized trauma management. critically examines impact TDI, direct indirect costs, quality life considerations, resource allocation. Special attention given age-specific management protocols, medically compromised patients, legal-ethical considerations. concludes an analysis future directions traumatology, providing framework continued advancement.

Language: Английский

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Fabrication and Characterization of 3D-Printed Porous Structures Based on Walstromite-Type Silicate Ceramics

Inorganics, Journal Year: 2025, Volume and Issue: 13(3), P. 68 - 68

Published: Feb. 25, 2025

This study investigates the additive manufacturing of 3D porous scaffolds based on walstromite-type silicate ceramics for bone tissue engineering applications. Walstromite powders were synthesized using sol-gel method and printed extrusion-based printing. Both sintered unsintered characterized scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-Ray diffraction (XRD) energy dispersive X-ray (EDS) analyses to evaluate effects sintering microstructure, porosity, mechanical properties. Results indicate that exhibited significantly higher compressive strength due presence organic binders, whereas demonstrated enhanced facilitating cell infiltration nutrient flow. Therefore, process reduced strength, probably loss compounds increased porosity. These findings underline need optimizing parameters balance integrity ensuring meet biological requirements regeneration. Alternative methods, such as microwave sintering, are also suggested future research minimize degradation observed post-sintering.

Language: Английский

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