International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138387 - 138387
Published: Dec. 1, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 672, P. 125323 - 125323
Published: Feb. 7, 2025
Language: Английский
Citations
0
Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 124 - 124
Published: Feb. 8, 2025
Nanogels are promising drug delivery systems since they possess undeniable advantages such as high loading capacity for hydrophilic and hydrophobic drugs, stabilization of sensitive biocompatibility, biodegradability. The present review summarizes experimental studies related to carriers, loading, membrane transport nanogels. In particular, the discusses properties, advantages, limitations polymeric carriers with respect behavior prepared nanogels in vivo conditions. potential nanogel encapsulation or drugs mechanisms release also emphasized. Moreover, challenges through barriers presented parenteral, oral, ocular, nasal, dermal routes administration considered.
Language: Английский
Citations
0
Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
Introduction Traditional administration routes have limitations including first-pass metabolism and gastrointestinal degradation for sensitive drugs (oral) pain associated with parenteral injections, which also require trained personnel refrigeration, making them expensive. This has increased interest in alternative routes, mucosal surfaces being of high priority.
Language: Английский
Citations
0
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 170 - 170
Published: Feb. 26, 2025
Cancer is a global health concern. Various therapeutic approaches, including chemotherapy, photodynamic therapy, and immunotherapy, have been developed for cancer treatment. Silica nanoparticles, quantum dots, metal–organic framework (MOF)-based nanomedicines gained interest in therapy because of their selective accumulation tumors via the enhanced permeability retention (EPR) effect. However, bare nanoparticles face challenges poor biocompatibility, low stability, limited drug-loading capacity, rapid clearance by reticuloendothelial system (RES). Gels with unique three-dimensional network structures formed through various interactions such as covalent hydrogen bonds are emerging promising materials addressing these challenges. Gel hybridization enhances facilitates controlled drug release, confers cancer-targeting abilities to nanoparticles. This review discusses gel–nanoparticle hybrid systems treatment past five years analyzes roles gels systems.
Language: Английский
Citations
0
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 190 - 190
Published: March 8, 2025
In recent years, hydrogels have emerged as promising candidates for bone defect repair due to their excellent biocompatibility, high porosity, and water-retentive properties. However, conventional face significant challenges in clinical translation, including brittleness, low mechanical strength, poorly controlled drug degradation rates. To address these limitations, a multifunctional polymer, polydopamine (PDA) has shown great potential both regeneration delivery systems. Its robust adhesive properties, responsiveness photothermal stimulation make it an ideal candidate enhancing hydrogel performance. Integrating PDA into not only improves properties but also creates environment conducive cell adhesion, proliferation, differentiation, thereby promoting repair. Moreover, facilitates release, offering approach optimizing treatment outcomes. This paper first explores the mechanisms through which promotes regeneration, laying foundation its translation. Additionally, discusses application of PDA-based nanocomposite advanced systems repair, providing valuable insights research
Language: Английский
Citations
0
Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 201 - 201
Published: March 14, 2025
This study investigates the synthesis and properties of innovative poly(oligo(alkylene glycol)) methacrylate hydrogels synthesized via gamma radiation-induced copolymerization crosslinking oligo(ethylene glycol) (OEGMA) oligo(propylene (OPGMA) at varying mole fractions. Our primary objective is to investigate impact on swelling P(OEGMA/OPGMA) compared their homopolymeric counterparts, namely, POEGMA POPGMA, which exhibit distinct volume phase transition temperatures (VPTTs) around 70 13 °C, respectively, under physiological conditions. To this end, a comprehensive library smart methacrylate-based hydrogel biomaterials was developed, featuring detailed data behavior across different copolymer molar ratios temperature ranges. achieve these objectives, we conducted analysis wide range temperatures, assessed pH sensitivity hydrogels, utilized scanning electron microscopy for morphological characterization, performed in vitro biocompatibility assessment through cell viability hemolysis assays, employed diclofenac sodium as model drug control delivery testing. findings demonstrate that newly P(OEGMA40/OPGMA60) copolymeric exhibits desirable characteristics, with VPTT close required controlled applications.
Language: Английский
Citations
0
Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 227 - 227
Published: March 22, 2025
In this project, a new class of temperature- and pH-sensitive hydrogel consisting N-isopropyl acrylamide (NIPAM), hydroxyethyl methacrylate (HEMA), (AAm) was prepared via controlled route through the reversible addition–fragmentation chain-transfer (RAFT) polymerization process. Poly(ethyleneglycol) dimethacrylate (PEG-DMA) used as long-chain hydrophilic biocompatible crosslinking agent. The structure confirmed by different characteristic techniques such 1H NMR, FT-IR, SEC, morphology particle diameters were checked scanning electron microscopy (SEM) dynamic light scattering (DLS) methods. Afterward, as-prepared hydrogel, poly(NIPAM-co-HEMA-co-AAm), loaded with doxorubicin (DOX) to be pH-triggered delivery carrier. system released DOX slowly at 37 °C neutral pH, but increased release significantly 42 acidic pH. anti-cancer efficiencies free DOX, DOX–hydrogel conjugate tested in vitro using human colorectal adenocarcinoma HT-29 cell lines. Cytotoxicity evaluation compared revealed that more cancer cells killed increasing concentration. Moreover, DOX-mediated apoptosis ROS levels showed beneficial effects poly(NIPAM-co-HEMA-co-AAm) for drug delivery. Generally, results suggest can potential candidate designing systems.
Language: Английский
Citations
0
European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113932 - 113932
Published: April 1, 2025
Language: Английский
Citations
0
Food Chemistry X, Journal Year: 2024, Volume and Issue: 24, P. 101974 - 101974
Published: Nov. 7, 2024
In the face of growing global challenges in food security and increasing demand for sustainable protein sources, aquaculture industry is undergoing a transformative shift through integration nanotechnology. This review paper explores profound role nanotechnology aquaculture, addressing critical issues such as efficient feed utilization, disease management, environmental sustainability. Nanomaterials are used to enhance nutritional content digestibility aquafeed, optimize fish growth health, improve prevention. Nanoparticle-based vaccines drug delivery systems reduce antibiotic reliance, while nano sensors monitor water quality real-time. Furthermore, has revolutionized infrastructure design, contributing smart, self-regulating systems. Despite its vast potential, ethical considerations long-term safety must be addressed. highlights nanotechnology's underscoring potential contribute significantly enhanced productivity
Language: Английский
Citations
3
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138387 - 138387
Published: Dec. 1, 2024
Language: Английский
Citations
0