Journal of Composites Science, Journal Year: 2025, Volume and Issue: 9(1), P. 31 - 31
Published: Jan. 10, 2025
The delivery of mesothelial cells by nanofibrous membranes (NFMs) can repair a damaged peritoneal mesothelium and enhance healing in patients with chronic renal failure. On the other hand, orientation nanofibers NFMs may affect cell attachment, proliferation, phenotype nanostructured scaffold. We prepare composite gelatin/chitosan aligned or random fiber orientations electrospinning. cross-link to maintain during vitro culture. then study cellular response attached From culture rat cells, prepared show high biocompatibility support growth, regardless orientation. However, alignment electrospun well-defined geometry promote adhesion proliferation rates directional organization. anisotropic arrangement NFM also coincides phenotypic maintenance biophysical cues provided nanofibers. find applications tissue engineering layer regenerative therapies where is critical for neo-tissue regeneration.
Language: Английский