Prognostic Factors for COVID-19 Hospitalized Patients with Preexisting Type 2 Diabetes

International Journal of Endocrinology, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 13

Published: Jan. 17, 2022

Type 2 diabetes (T2D) as a worldwide chronic disease combined with the COVID-19 pandemic prompts need for improving management of hospitalized patients preexisting T2D to reduce complications and risk death. This study aimed identify clinical factors associated outcomes specifically targeted at build an individualized prediction nomogram stratification early intervention mortality.In this retrospective study, characteristics 382 confirmed patients, consisting 108 274 without T2D, from January 8 March 7, 2020, in Tianyou Hospital Wuhan, China, were collected analyzed. Univariate multivariate Cox regression models performed specific mortality T2D. An was developed evaluated by discrimination calibration.Nearly 15% (16/108) died. Twelve predictive identified. Older age (HR = 1.076, 95% CI 1.014-1.143, p=0.016), elevated glucose level 1.153, 1.038-1.28, p=0.0079), increased serum amyloid A (SAA) 1.007, 1.001-1.014, p=0.022), treatment only oral medication 0.152, 95%CI 0.032-0.73, p=0.0036), plus insulin 0.095, 0.019-0.462, p=0.019) independent prognostic factors. based on these built 7-day, 14-day, 21-day survival patients. High concordance index (C-index) achieved, calibration curves showed model had good ability within three weeks onset.By incorporating factors, provided user-friendly graphical tool clinicians quickly high-risk COVID-19.

Language: Английский

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Risk stratification and prognostic value of prothrombin time and activated partial thromboplastin time among COVID-19 patients

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(8), P. e0272216 - e0272216

Published: Aug. 11, 2022

Background COVID-19 is a viral disease caused by new strain of corona virus. Currently, prognosis and risk stratification patients done the disease’s clinical presentation. Therefore, identifying laboratory biomarkers for critical prompt treatment. main objective this study was to assess prognostic value basic coagulation parameters factors associated with severity among at Tibebe Ghion Specialized Hospital, treatment center, Northwest Ethiopia. Methods A follow-up conducted conveniently recruited attended from March June 2021. Socio-demographic data were collected using structured questionnaire checklist, respectively. Prothrombin time (PT) activated partial thromboplastin (APTT) analyzed HUMACLOT DUE PLUS ® machine. Descriptive statistics used summarize socio-demographic characteristics participants. Kruskal Wallis tests compare difference between parametric non-parametric continuous variables, The area under receiver operating characteristic curve (AUC) evaluate PT APTT in patients. Ordinal logistic regression identify prognosis. P-value < 0.05 defined as statistically significant all results. Result Baseline cut-off ≥ 16.25 seconds differentiated severe mild moderate (AUC: 0.89, 95% CI: 0.83–0.95). also ≤ 15.35 0.90, 0.84–0.96). Moreover, alcohol drinkers 3.52 times more likely chance having than non-drinkers (95% 1.41–8.81). one-year increment age increased odds 6% 3–9%). An 0.65 baseline predicted poor 0.93, 0.87–0.99). Conclusions recommendations Prolonged observed worsen increase can be marker

Language: Английский

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Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility

Infection Genetics and Evolution, Journal Year: 2022, Volume and Issue: 104, P. 105357 - 105357

Published: Aug. 28, 2022

The ACE2 protein acts as a gateway for SARS-CoV-2 in the host cell, playing an essential role susceptibility to infection by this virus. Genetics and epigenetic mechanisms related gene are associated with changes its expression and, therefore, linked increased infection. Although some variables such sex, age, obesity have been described risk factors COVID-19, molecular causes involved disease still unknown. To evaluate profiles their association demographic or clinical variables. In 500 adult volunteers, mRNA levels of nasopharyngeal swab samples methylation status peripheral blood were quantified RT-qPCR qMSP, respectively. existence significant differences determinants evaluated different study groups according several body mass index (BMI), smoking, infection, presence underlying diseases type II diabetes mellitus (DM2), asthma arterial hypertension (AHT). Our results show that overexpression, directly depends on multiple male age over 30 years, obesity, DM2. Likewise, it was determined is regulated DNA patterns promoter region. highly variable, variability habits smoking variables, which details impact environmental our epigenome

Language: Английский

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Bacterial and Fungal Co-Infections and Superinfections in a Cohort of COVID-19 Patients: Real-Life Data from an Italian Third Level Hospital

Infectious Disease Reports, Journal Year: 2022, Volume and Issue: 14(3), P. 372 - 382

Published: May 12, 2022

The use of immune suppressive drugs combined with the natural suppression caused by SARS-CoV-2 can lead to a surge secondary bacterial and fungal infections. aim this study was estimate incidence superinfections in hospitalized subjects COVID-19. We carried out an observational retrospective single center cohort study. enrolled patients admitted at "Garibaldi" hospital for ≥72 h, confirmed diagnosis All were routinely investigated bacterial, viral, pathogens. A total 589 adults COVID-19 included. 88 infections documented different sites among 74 (12.6%). As etiology, 84 isolates (95.5%), while only 4 (4.5%). 51 episodes hospital-acquired (HAI) found 43 patients, etiology 47 cases (92.2%). Community-acquired (CAIs) are more frequently Streptococcus pneumoniae, HAIs mostly associated Pseudomonas aeruginosa. high rate CAIs due high-dose corticosteroids long stays be suspected. should evaluated infection colonization. More data about antimicrobial resistance its correlation antibiotic misuse required.

Language: Английский

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SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Promote a Proinflammatory Activation Profile on Human Dendritic Cells

Cells, Journal Year: 2021, Volume and Issue: 10(12), P. 3279 - 3279

Published: Nov. 23, 2021

Dendritic cells (DCs) are the most potent antigen-presenting cells, and their function is essential to configure adaptative immunity avoid excessive inflammation. DCs predicted play a crucial role in clinical evolution of infection by severe acute respiratory syndrome (SARS) coronavirus (CoV)-2. interaction with SARS-CoV-2 Spike protein, which mediates cell receptor binding subsequent fusion viral particle host cell, key step induce effective against this virus S protein-based vaccination protocols. Here we evaluated human response or fragment encompassing domain (RBD) challenge. Both proteins increased expression maturation markers, including MHC molecules costimulatory receptors. protein promotes activation signaling involved inflammation, MAPK, AKT, STAT1, NFκB, correlates secretion distinctive proinflammatory cytokines. Differences ACE2 along differentiation monocytes mature inter-donor were found. Our results show that inflammatory provides molecular links between individual variations degree virus.

Language: Английский

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