Chinese Medical Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
The
rise
in
global
life
expectancy
has
led
to
an
increase
the
older
population,
presenting
significant
challenges
managing
infectious
diseases.
Aging
affects
innate
and
adaptive
immune
systems,
resulting
chronic
low-grade
inflammation
(inflammaging)
function
decline
(immunosenescence).
These
changes
would
impair
defense
mechanisms,
susceptibility
infections
reduce
vaccine
efficacy
adults.
Cellular
senescence
exacerbates
these
issues
by
releasing
pro-inflammatory
factors,
further
perpetuating
inflammation.
Moreover,
comorbidities,
such
as
cardiovascular
disease
diabetes,
which
are
common
adults,
amplify
dysfunction,
while
immunosuppressive
medications
complicate
responses
infections.
This
review
explores
molecular
cellular
mechanisms
driving
inflammaging
immunosenescence,
focusing
on
genomic
instability,
telomere
attrition,
mitochondrial
dysfunction.
Additionally,
we
discussed
how
aging-associated
alterations
influence
bacterial,
viral,
parasitic
evaluated
emerging
antiaging
strategies,
aimed
at
mitigating
effects
improve
health
outcomes
aging
population.
npj Aging,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: April 6, 2024
Abstract
The
US
healthcare
system
is
at
a
crossroads.
With
an
aging
population
requiring
more
care
and
strained
facing
workforce
shortages,
capacity
issues,
fragmentation,
innovative
solutions
policy
reforms
are
needed.
This
paper
aims
to
spark
dialogue
collaboration
among
stakeholders
inspire
action
meet
the
needs
of
population.
Through
comprehensive
analysis
impact
society,
this
work
highlights
urgency
addressing
issue
importance
restructuring
be
efficient,
equitable,
responsive.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(4), P. 775 - 775
Published: April 11, 2024
Immune
system
aging
is
becoming
a
field
of
increasing
public
health
interest
because
prolonged
life
expectancy,
which
not
paralleled
by
an
increase
in
expectancy.
As
age
progresses,
innate
and
adaptive
immune
systems
undergo
changes,
are
defined,
respectively,
as
inflammaging
senescence.
A
wealth
available
data
demonstrates
that
these
two
conditions
closely
linked,
leading
to
greater
vulnerability
elderly
subjects
viral,
bacterial,
opportunistic
infections
well
lower
post-vaccination
protection.
To
face
this
novel
scenario,
in-depth
assessment
the
players
involved
changing
epidemiology
demanded
regarding
individual
concerted
involvement
cells
mediators
within
endogenous
exogenous
factors
co-morbidities.
This
review
provides
overall
updated
description
changes
affecting
system,
may
be
help
understanding
underlying
mechanisms
associated
with
main
age-associated
infectious
diseases.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(3), P. 260 - 260
Published: Feb. 22, 2024
Anti-ageing
biology
and
medicine
programmes
are
a
focus
of
genetics,
molecular
biology,
immunology,
endocrinology,
nutrition,
therapy.
This
paper
discusses
metabolic
therapies
aimed
at
prolonging
longevity
and/or
health.
Individual
components
these
effects
postulated
to
be
related
the
energy
supply
by
tricarboxylic
acid
(TCA)
cycle
intermediates
free
radical
production
processes.
article
presents
several
theories
ageing
clinical
descriptions
top
markers
ageing,
which
define
in
different
categories;
additionally,
their
interactions
with
age-related
changes
diseases
α-ketoglutarate
(AKG)
succinate
SC
formation
metabolism
pathological
states
explained.
review
describes
convincingly
differences
mitochondrial
characteristics
animals,
levels
(high
low)
physiological
reactivity
functional
systems
state
regulatory
providing
oxygen-dependent
Much
attention
is
given
crucial
role
AKG
cells
amino
synthesis,
epigenetic
regulation,
cell
stemness,
differentiation,
as
well
associated
development
conditions
and,
particular,
cancer
cells.
Another
goal
was
address
issue
terms
individual
reactivity.
also
demonstrated
Krebs
key
component
cellular
closely
various
pathologies,
such
cancer,
type
2
diabetes,
cardiovascular
or
neurodegenerative
where
mTOR
pathway
plays
role.
provides
postulates
postischaemic
phenomena
an
organism
demonstrates
dependence
accelerated
pathology
on
studies
species
(roundworm
Caenorhabditis
elegans,
Drosophila,
mice,
humans
used
models).
The
findings
suggest
that
this
approach
may
useful
show
metabolites
involved
abnormalities
thus
induce
reprogramming
contributes
senile
phenotype
degenerative
diseases.
compounds
particularly
important
when
considering
mechanisms
connected
initial
able
initiate
programmed
depending
intensity
oxygen
consumption,
peculiarities,
behavioural
reactions.
Frontiers in Genetics,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 13, 2024
Background:
Physical
weakness
and
cardiovascular
risk
increase
significantly
with
age,
but
the
underlying
biological
mechanisms
remain
largely
unknown.
This
study
aims
to
reveal
causal
effect
of
circulating
metabolites
on
frailty,
sarcopenia
vascular
aging
related
traits
diseases
through
a
two-sample
Mendelian
Randomization
(MR)
analysis.
Methods:
Exposures
were
486
analyzed
in
genome-wide
association
(GWAS),
while
outcomes
included
sarcopenia,
arterial
stiffness,
atherosclerosis,
peripheral
disease
(PAD)
aortic
aneurysm.
Primary
estimates
calculated
using
inverse-variance
weighted
(IVW)
method.
Methods
including
MR
Egger,
median,
Q-test,
leave-one-out
analysis
used
for
sensitive
Results:
A
total
125
suggestive
causative
associations
between
identified.
Seven
strong
links
ultimately
identified
six
(kynurenine,
pentadecanoate
(15:0),
1-arachidonoylglycerophosphocholine,
androsterone
sulfate,
glycine
mannose)
three
(sarcopenia,
PAD
atherosclerosis).
Besides,
metabolic
pathway
13
significant
pathways
6
age-related
diseases.
Furthermore,
metabolite-gene
interaction
networks
constructed.
Conclusion:
Our
research
suggested
new
evidence
relationship
diseases,
which
may
hold
promise
as
valuable
biomarkers.
Frontiers in Public Health,
Journal Year:
2024,
Volume and Issue:
12
Published: July 31, 2024
Objective
This
study
aimed
to
evaluate
the
association
between
six
complete
blood
count
(CBC)-derived
inflammatory
markers
[neutrophil-to-lymphocyte
ratio
(NLR),
monocyte-to-lymphocyte
(MLR),
platelet-to-lymphocyte
(PLR),
systemic
immune-inflammatory
index
(SII),
response
(SIRI),
and
pan-immune
inflammation
value
(PIV)]
risk
of
frailty
mortality.
Methods
Data
were
obtained
from
National
Health
Nutrition
Examination
Survey
(NHANES)
1999–2018.
Mortality
was
identified
using
Death
Index
until
December
31,
2019.
Multiple
logistic
regression
analysis
conducted
CBC-derived
frailty.
The
Cox
model
assessed
mortality
in
frail
populations.
Restricted
cubic
spline
(RCS)
used
visualize
with
risk.
predictive
for
further
a
random
survival
forest
(RSF)
approach.
Results
analyzed
data
total
16,705
middle-aged
older
participants.
Among
them,
6,503
participants
frail,
rate
41.47%.
showed
that
NLR,
MLR,
PLR,
SII,
SIRI,
PIV
positively
associated
revealed
highest
quartile
had
significantly
increased
death
compared
those
lowest
quartile:
NLR
(HR
=
1.73,
95%
CI:1.54,
1.94),
MLR
1.71,
CI:1.51,
1.93),
PLR
1.28,
95%CI:
1.15,
1.43),
SII
1.50,
95%CI:1.34,
1.68),
SIRI
1.88,
CI
95%:1.67,
2.12),
1.55,
95%CI:1.38,
1.73).
Random
analyses
demonstrated
adult
Conclusion
results
suggest
are
higher
as
well
middle
old-aged
population
United
States.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 29, 2025
Introduction
The
aging
process
is
frequently
associated
with
a
decline
in
functional
capacity,
endurance,
muscle
quality,
and
overall
quality
of
life.
Examining
aging-related
biomarkers
often
requires
significant
time
financial
resources,
underscoring
the
need
for
straightforward
practical
indicator.
This
study
aims
to
investigate
association
between
handgrip
strength
laboratory
parameters
elderly
population
Indonesia.
Methods
A
cross-sectional
was
conducted
involving
109
participants
aged
60–82
years.
Handgrip
measured
using
Jamar
hydraulic
hand
dynamometer
PLUS+
digital
dynamometer.
Aging-related
were
defined
as
those
indicating
physiological
processes.
Results
revealed
several
parameters,
including
leukocyte
count,
absolute
neutrophil
lymphocyte
neutrophil/lymphocyte
ratio,
erythrocyte
sedimentation
rate.
Discussion
These
findings
suggest
that
could
serve
cost-effective,
non-invasive
predictor
health
status
older
adults.
Its
utility
highlights
its
potential
guiding
interventions
targeting
population.
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(6), P. 566 - 566
Published: May 22, 2024
The
share
of
the
elderly
population
is
growing
worldwide
as
life
expectancy
increases.
Immunosenescence
and
comorbidities
increase
infectious
diseases’
morbidity
mortality
in
older
adults.
Here,
we
aimed
to
summarize
latest
findings
on
vaccines
for
against
herpes
zoster,
influenza,
respiratory
syncytial
virus
(RSV),
COVID-19,
pneumococcal
disease
examine
vaccine
recommendation
differences
this
age
group
Europe
United
States.
PubMed
was
searched
using
keywords
“elders”
“vaccine”
alongside
disease/pathogen
question
paraphrased
or
synonymous
terms.
Vaccine
recommendations
were
also
sought
European
US
Centers
Disease
Control
Prevention
databases.
Improved
vaccines,
tailored
elderly,
mainly
by
novel
adjuvants
increasing
antigen
concentration,
are
now
available.
Significant
exist
between
immunization
policies,
especially
countries,
terms
recipient’s
age,
number
doses,
vaccination
schedule,
implementation
(mandatory
recommended).
Understanding
factors
that
influence
immune
response
may
help
design
offer
long-term
protection
vulnerable
group.
A
consensus-based
strategy
could
fill
gaps
policy
particularly
regarding
RSV
pneumococcus.
Mechanisms of Ageing and Development,
Journal Year:
2023,
Volume and Issue:
215, P. 111872 - 111872
Published: Sept. 8, 2023
Inflammaging
is
a
low-grade
inflammatory
state
that
can
be
considered
an
adaptive
process
aimed
at
stimulating
appropriate
anti-inflammatory
response.
Frailty
determined
by
the
accumulation
of
molecular
and
cellular
defects
accumulated
throughout
life;
therefore,
frailty
computation
could
valuable
tool
for
measuring
biological
age.
This
study
aims
to
analyse
association
between
markers
both
chronological
age
"per
se"
frailty.
We
studied
452
persons
aged
43-114
years.
A
Index
(FI)
was
computed
considering
wide
range
age-related
signs,
symptoms,
disabilities,
diseases.
Plasma
concentrations
cytokines
peripheral
neuroinflammation
were
analysed
next-generation
ELISA.
The
mean
cohort
79.7
(from
43
114)
years
median
FI
0.19
0.00
0.75).
most
increased
significantly
with
age,
after
adjustment
sex
FI.
Interferon-γ
affected
only
FI,
while
interleukin
(IL)-10
IL-1β
associated
In
conclusion,
we
described
different
associations
components
vs.
better
characterization
signature
aging
help
understand
complexity
this
process.
