Chinese Medical Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
The
rise
in
global
life
expectancy
has
led
to
an
increase
the
older
population,
presenting
significant
challenges
managing
infectious
diseases.
Aging
affects
innate
and
adaptive
immune
systems,
resulting
chronic
low-grade
inflammation
(inflammaging)
function
decline
(immunosenescence).
These
changes
would
impair
defense
mechanisms,
susceptibility
infections
reduce
vaccine
efficacy
adults.
Cellular
senescence
exacerbates
these
issues
by
releasing
pro-inflammatory
factors,
further
perpetuating
inflammation.
Moreover,
comorbidities,
such
as
cardiovascular
disease
diabetes,
which
are
common
adults,
amplify
dysfunction,
while
immunosuppressive
medications
complicate
responses
infections.
This
review
explores
molecular
cellular
mechanisms
driving
inflammaging
immunosenescence,
focusing
on
genomic
instability,
telomere
attrition,
mitochondrial
dysfunction.
Additionally,
we
discussed
how
aging-associated
alterations
influence
bacterial,
viral,
parasitic
evaluated
emerging
antiaging
strategies,
aimed
at
mitigating
effects
improve
health
outcomes
aging
population.
British Journal of Community Nursing,
Journal Year:
2025,
Volume and Issue:
30(3), P. 118 - 122
Published: Feb. 26, 2025
Nearly
a
million
people
are
living
with
dementia
in
the
UK,
and
less
than
65%
of
them
have
been
formally
diagnosed
according
to
Alzheimer's
Society.
Dementia
exists
on
continuum
can
mild,
moderate
or
severe
symptoms.
People
more
likely
experience
health
problems
same
age
who
do
not
dementia.
affects
ability
understand
relate
world
manage
conditions.
This
article
discusses
how
person
be
helped
maintain
enjoy
best
possible
quality
life.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(3), P. 721 - 721
Published: March 15, 2025
Background/Objectives:
Immunosenescence
implies
innate
and
adaptive
immunity
dysfunction,
which
naturally
occurs
with
aging.
It
is
a
complex
multifactorial
process
can
be
triggered
by
either
genetic
changes,
immune
changes
or
both.
Numerous
research
studies
have
shown
that
the
of
senescence
goes
alongside
chronic
activation.
The
purpose
this
study
to
analyze
in
expression
genes
associated
responses
order
identify
reliable
biomarkers
for
Methods:
For
aim,
55
clinically
healthy
individuals
active
age
(21–65
years)
were
distributed
based
on
immunophenotyping
two
groups,
without
signs
premature
senescence.
A
gene
analysis
was
subsequently
made
those
differentially
expressed
presented
interpreted.
Results:
Altogether,
forty-eight
(48)
exhibited
differential
between
most
showed
up-regulation
(45)
(fold
change
more
than
2),
only
three
down-regulated
less
−2).
highest
positive
fold
IL-1β
(10.76),
BCL6
(13.25)
CCL4
(15.91),
while
negative
documented
IL23R
(−3.10),
IL5
(−2.66)
PTGS2
(COX-2)
(−2.15).
Conclusions:
Our
results
reveal
immunosenescence
positively
inflammation,
typical
aging
process.
On
other
hand,
we
identified
markers
possible
protective
effects
against
oxidative
stress
tumorigenesis.
These
findings
aid
early
diagnosis
degenerative
diseases
subclinical
phase,
as
well
development
strategies
prevent
processes
BMJ Public Health,
Journal Year:
2025,
Volume and Issue:
3(1), P. e001941 - e001941
Published: Jan. 1, 2025
Objectives
To
easily
detect
frailty
in
a
timely
fashion,
enabling
targeted
interventions
and
appropriate
monitoring,
will
be
major
worldwide
public
health
economic
challenge
as
the
proportion
of
older
people
increases
population.
Based
on
review
meta-analysis
showing
that
C-reactive
protein
(CRP),
haemoglobin,
albumin
vitamin
D
are
associated
with
frailty,
we
aimed
to
develop
validate
biological
score
using
these
biomarkers
for
detection
frailty.
Design
We
conducted
retrospective,
cross-sectional,
monocentric
study
electronic
healthcare
database
Lille
University
Hospital,
France.
Participants
Inclusion
criteria
were
patients
aged
50
over,
being
hospitalised
at
Hospital
between
1
January
2008
31
December
2021.
identified
whose
CRP,
levels
measured.
selected
assays
fell
within
normal
thresholds,
outside
acute
clinical
situations.
Main
outcome
measures
assess
used
scale
adapted
database,
called
Frailty
Risk
Score.
predictive
score,
whole
population
was
divided
into
development
validation
cohort.
Results
26
554
included,
which
17
702
cohort
8852
results
multivariate
analysis,
developed
an
equation
combining
age
sex
obtain
referred
bFRAil
(biological
FRAilty)
score.
Within
cohort,
area
under
curve
this
is
0.78
(0.77–0.80)
negative
value
83.7%.
Conclusions
This
has
made
it
possible,
first
time,
hospital
setting
based
simple,
measurable
identifying
frail
daily
medical
practice.
Further
studies
needed
its
use.
Journal of Texture Studies,
Journal Year:
2025,
Volume and Issue:
56(2)
Published: March 1, 2025
Textural
modification
and
nutritional
customization
of
food
is
considered
an
effective
strategy
to
ensure
safe
swallowing
prevent
malnutrition
in
people
with
dysphagia,
while
improving
quality
life
physical
health.
The
aim
the
present
study
was
evaluate
effect
added
fat
15%-16%
(in
form
pork
fat,
liquid
oil
or
bigel
structured
collagen
mono-
diglycerides
fatty
acids),
fibers
(3.0%)
lingonberry
pomace
protein
(2.0%-3.0%)
as
well
interactions
between
them
on
stability,
rheological
textural
properties,
color
printing
performance
meat-based
ink
formulations
its
application
dysphagia
diet.
Results
showed
that
all
samples
exhibited
shear-thinning
behavior
(the
viscosity
a
material
decreases
shear
rate
increases)
n
<
1.
Pork
fiber
incorporation
increase
concentration
affected
apparent
viscosity,
consistency
coefficient,
elasticity
loss
modulus
values.
Structured
addition
helped
create
more
stable
gel-like
network
(confirmed
by
higher
elastic
G'
hardness
values)
provided
stability
matrix
trapping
inside
phase,
affecting
post-printing
(>
98%)
after
thermal
treatment
(80%-93%).
Thermally
treated
were
selected
labeled
Level
6
(soft
bite-sized),
defined
International
Dysphagia
Diet
Standardization
Initiative
(IDDSI)
framework,
suggesting
they
suit
mild
dysphagia.
outcome
this
provides
insights
into
how
tailor
meet
needs
patients.
Frontiers in Genetics,
Journal Year:
2024,
Volume and Issue:
15
Published: July 12, 2024
Background:
Although
genome-wide
association
studies
(GWAS)
have
identified
14
loci
associated
with
frailty
index
(FI)
susceptibility,
the
underlying
causative
genes
and
biological
mechanisms
remain
elusive.
Methods:
A
cross-tissue
transcriptome-wide
study
(TWAS)
was
conducted
utilizing
Unified
Test
for
Molecular
Markers
(UTMOST),
which
integrates
GWAS
summary
statistics
from
164,610
individuals
of
European
ancestry
10,616
Swedish
participants,
alongside
gene
expression
matrices
Genotype-Tissue
Expression
(GTEx)
Project.
Validation
significant
performed
through
three
distinct
methods:
FUSION,
FOCUS,
Multiple
Marker
Analysis
Genome-wide
Annotation
(MAGMA).
Exploration
tissue
functional
enrichment
FI-associated
SNPs
using
MAGMA.
Conditional
joint
analyses,
along
fine
mapping,
were
employed
to
enhance
our
understanding
FI’s
genetic
architecture.
Mendelian
randomization
ascertain
causal
relationships
between
FI,
co-localization
analysis
utilized
investigate
shared
FI.
Results:
In
this
study,
two
novel
susceptibility
risk
FI
application
four
TWAS
methods.
demonstrated
that
HTT
may
elevate
developing
frailty,
whereas
LRPPRC
could
offer
protection
against
onset
frailty.
Additionally,
a
SNP
Tissue
analyses
revealed
genomic
regions
linked
predominantly
enriched
in
various
brain
regions,
including
frontal
cortex,
cerebral
cerebellar
hemispheres.
Conditional,
combined
mapping
collectively
frailty:
2p21
4q16.3.
Functional
pathways
primarily
related
MHC
complex,
PD-1
signaling,
cognition,
inflammatory
response
antigenic
stimuli,
production
second
messenger
molecules.
Conclusion:
This
investigation
uncovers
newly
forecasted
levels
offering
new
perspectives
on
architecture
Frontiers in Public Health,
Journal Year:
2023,
Volume and Issue:
11
Published: Nov. 7, 2023
Backgrounds
Frailty
is
a
significant
problem
for
older
persons
since
it
linked
to
number
of
unfavorable
consequences.
According
observational
researches,
air
pollution
may
raise
the
risk
frailty.
We
investigated
causal
association
between
frailty
and
(including
PM
2.5
,
2.5–10
10
nitrogen
dioxide,
oxides)
using
Mendelian
randomization
approach.
Methods
conducted
MR
analysis
extensive
publically
accessible
GWAS
(genome-wide
studies)
summary
data.
The
inverse
variance
weighted
(IVW)
method
was
employed
as
primary
method.
median
model,
MR-Egger,
simple
model
approaches
were
chosen
quality
control.
Cochran’s
Q
test
utilized
evaluate
heterogeneity.
Pleiotropy
found
MR-Egger
regression
test.
MR-PRESSO
used
recognize
outliers.
leave-one-out
strategy
conduct
sensitivity
analysis.
Results
results
suggested
that
statistically
significantly
associated
with
[odds
ratio
(OR)
=
1.33;
95%confidence
interval
(CI)
1.12–1.58,
p
0.001]
in
IVW
observed
no
statistical
(OR
1.00,
95%
CI
0.79–1.28,
0.979),
0.91,
0.75–1.11,
0.364),
dioxide
0.98,
0.85–1.12,
0.730),
oxides
1.15,
0.98–1.36,
0.086)
There
pleiotropy
results.
based
on
showed
individual
single
nucleotide
polymorphisms
(SNPs)
did
not
affect
robustness
Conclusion
current
investigation
shows
Frailty’s
detrimental
progression
be
slowed
down
help
prevention
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 23, 2024
Background
Despite
the
recognized
link
between
immune
responses
and
frailty,
association
cell
counts
frailty
based
on
previous
observational
studies
remains
disputed,
with
uncertain
causal
nexus.
This
study
aimed
to
elucidate
genetically
predicted
circulating
frailty.
Methods
We
conducted
two-sample
Mendelian
randomization
(MR)
independent
genetic
variants
associated
six
subtype
from
genome-wide
in
563,946
European
individuals.
Frailty
summary
data,
assessed
via
index
(FI),
was
obtained
comprising
175,226
subjects.
Univariate
MR,
reverse
MR
multivariate
were
comprehensive
investigate
FI,
two-step
analysis
for
mediation
analysis.
Results
evidence
indicated
that
among
leukocyte
counts,
only
elevated
eosinophil
count
significantly
correlated
higher
FI
(β
=
0.059,
95%
confidence
interval
[CI],
0.042–0.078,
P
=5.63E-11),
no
relationship
identified
MR.
In
effect
of
retained
statistical
significance
0.063,
CI,
0.021–0.104,
0.003).
Ultimately,
demonstrated
two
mediators
this
pathway:
asthma
(β=
0.019,
0.013–0.025,
35.84E-10,
mediated
proportion,
31.732%)
rheumatoid
arthritis
0.004,
0.001–0.006,
=1.75E-03,
6.411%).
Conclusions
Within
subtypes,
had
irreversible
possibly
serving
as
partial
mediators.
The
finding
stressed
need
further
exploring
physiological
functions
eosinophils
order
develop
effective
strategies
against
Medical Hypotheses,
Journal Year:
2024,
Volume and Issue:
186, P. 111322 - 111322
Published: March 14, 2024
Inflamm-aging
is
a
condition
of
low-grade
and
chronic
systemic
inflammation
characterized
by
increase
in
multiple
inflammatory
biomarkers
such
as
tumor
necrosis
factor
(TNF),
interleukin
6
(IL-6),
C-reactive
protein
(CRP),
CXCL9
(MIG)
experimental
clinical
settings.
However,
despite
the
recent
identification
extracellular
procathepsin
L
(pCTS-L)
novel
mediator
diseases
sepsis,
its
possible
role
inflamm-aging
was
previously
not
investigated.
In
present
study,
we
compared
blood
levels
pCTS-L
other
62
cytokines
chemokines
between
young
aged
Balb/C
mice
Western
blotting
Cytokine
Antibody
Arrays.
light
surprising
finding
marked
mice,
propose
that
may
serve
another
biomarker
inflamm-aging.
Given
capacity
inducing
various
(e.g.,
TNF
IL-6),
it
will
be
important
to
test
hypothetic
under
conditions.
