Biogerontology, Journal Year: 2024, Volume and Issue: 26(1)
Published: Oct. 29, 2024
Language: Английский
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102278 - 102278
Published: March 19, 2024
Vascular dementia (VaD) is the second most common type of dementia. VaD synonymous with ageing, and its symptoms place a significant burden on health wellbeing older people. Despite identification substantial number risk factors for VaD, pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, biogerontological imperative exists highlight modifiable lifestyle which can mitigate against developing VaD. This review will critically examine some have been revealed modulate risk. The survey commences by providing an overview putative are associated pathobiology Next, influence examined. Finally, emerging treatment avenues including epigenetics, gut microbiome, pro-longevity pharmaceuticals discussed. By drawing key evidence together, it our hope that used inform future experimental investigations in field.
Language: Английский
Citations
15
Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: 187, P. 21 - 35
Published: Feb. 3, 2024
Language: Английский
Citations
5
OBM Geriatrics, Journal Year: 2023, Volume and Issue: 07(04), P. 1 - 23
Published: Oct. 11, 2023
Both from a healthcare and socioeconomic perspective, research on senescence is increasingly essential. Indeed, in industrialized countries, the increased human longevity confronts medicine with many old patients age-related pathologies. The paper reviews biological theories aging, impact of reactive oxygen species, telomers, epigenetics, genetics (e.g., gerontogenes) on-age-related Also, available under therapeutic approaches senolytics) aimed to prolong life span reduce morbidity related age.
Language: Английский
Citations
2
Experimental Gerontology, Journal Year: 2023, Volume and Issue: 184, P. 112324 - 112324
Published: Nov. 22, 2023
What are the structural components and physiological mechanisms determining aging process? Can different described in biology converge into a core of coordinated effectors? Why some human beings, for instance, can reach 115-122 years age while rats live at best maximum 4 years? rate be modified? How much lifespan extended? Is programmed or non-programmed This special issue includes invited articles to explore aging, both classical updated hypotheses on evolutionary meaning aging. Breakthroughs aging-related research currently unveiling longevity factors highly conserved during evolution animal species discovering details how why molecular cellular processes decline physiologically normal Investigations model organisms humans uncovering potential approaches extend not only mean individual survival but also (from here on) longevity. Experimental Gerontology presents this Special Issue (SI) highlighting recent advances mechanistic understanding longevity, interventions that lifespan. SI address most reasonably well known tries evaluate available evidence supporting opposed biological exists all?. The is composed ten peer reviewed reviews primary articles, covering basic concepts with specific focus mitochondrial function, mitROS production (mitROSp), mitDNA damage caloric restriction; autophagy; role dietary antioxidants; drug has consistently demonstrated (ITP/NIA/NIH program performed three independent laboratories) increases mammals over controls: rapamycin; heterochronic parabiosis; secondary inflammaging; epigenetics control nuclear program, hypothetical existence peripheral central clocks.
Language: Английский
Citations
2
Published: Jan. 1, 2024
Language: Английский
Citations
0
Journal of Urban Health Research, Journal Year: 2024, Volume and Issue: 2(3), P. 25 - 41
Published: Aug. 15, 2024
Background: Extensive studies have reported the involvement of epigenetic dynamics in aging. Common modifications aging include methylation DNA, rearrangement chromatin, and regulation gene expression by non-coding RNA (ncRNA). Some important conclusions that emerged from various past few decades are lifespan living organisms is largely determined epigenetics instead genetics, where environmental lifestyle influences change information a dominant effect. Purpose: This study aims to review current understanding mechanisms involved during would provide new insights for development strategies prevent Methods: A search literature regarding regulations biological was carried out Web Science Scopus on “epigenetics” [AND] “aging”. In this study, we used total 73 articles published between 2010 2024. Results: Aging accompanied alterations marks, including DNA (global hypomethylation non-CpG regions hypermethylation OF CpG islands), chromatin reduction histones redistribution histone modifications), ncRNA (particularly miRNA). Epigenetic reversible molecular mechanism allow therapeutic interventions improve or reverse aging-related pathogenesis. Chemical-based manipulation lifestyle-based reprogramming can be developed conditions. Conclusion: Based extensive review, found changes potential biomarkers early detection age-related diseases. Drugs target key signatures therefore promising intervene Keywords: - disease biomarker
Language: Английский
Citations
0
Biogerontology, Journal Year: 2024, Volume and Issue: 26(1)
Published: Oct. 29, 2024
Language: Английский
Citations
0