İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi,
Journal Year:
2024,
Volume and Issue:
24, P. 1270 - 1278
Published: Dec. 30, 2024
Aim:
This
study
aimed
to
examine
the
relationship
between
frailty,
successful
aging,
and
physical
activity
levels
in
older
individuals.
Method:
Data
were
collected
from
99
volunteer
participants
aged
≥65.
The
questionnaire
was
delivered
online
via
its
Google
Forms
link.
In
study,
Tilburg
Frailty
Indicator
(TFI)
used
evaluate
participants’
frailty
levels,
Successful
Aging
Scale
(SAS)
utilized
determine
their
aging
status,
International
Physical
Activity
Questionnaire-Short
Form
(IPAQ-SF)
employed
measure
levels.
Results:
results
of
revealed
a
moderate,
significant
negative
correlation
TFI
SAS
total
scores.
Additionally,
weak,
positive
found
IPAQ-SF
scores
(s=0.982;
p<0.001).
A
detected
component
score
score.
There
significant,
highly
healthy
lifestyle
sub-parameter
(s=-.0634;
Conclusion:
It
has
been
determined
that
more
active
individuals
exhibit
both
healthier
lower
frailty.
women
have
be
statistically
frail
less
compared
men.
observed
increases
with
age.
Geriatrics,
Journal Year:
2025,
Volume and Issue:
10(1), P. 9 - 9
Published: Jan. 7, 2025
Background/Objectives:
Frailty
screening
facilitates
the
identification
of
older
adults
at
risk
adverse
health
outcomes.
The
Program
Research
to
Integrate
Services
for
Maintenance
Autonomy
7
(PRISMA-7)
is
a
widely
utilised
frailty
tool;
however,
concerns
regarding
its
potential
sex
bias
persist
due
item
2,
which
assigns
point
male
sex.
This
study
compared
PRISMA-7
with
modified
version,
PRISMA-6
(excluding
2),
assess
their
suitability
in
South
Tyrol,
Italy.
Objectives
included
evaluating
impact
2
on
classification
and
exploring
feasibility
as
more
equitable
alternative.
Methods:
A
cross-sectional
survey
1695
community-dwelling
aged
≥75
years
was
conducted
Tyrol.
assessed
using
both
PRISMA-6.
Sociodemographic,
health,
lifestyle
data
were
collected
examine
associations
classifications.
Logistic
regression
applied
identify
predictors
each
tool.
Agreement
between
assessed,
internal
consistency
evaluated
Cronbach's
alpha.
Results:
prevalence
33.9%
27.0%
classified
men
frail
frequently
than
women
(34.7%
vs.
33.0%),
while
reversed
this
trend
(men,
21.4%;
women,
33.0%).
Excluding
improved
(Cronbach's
alpha:
PRISMA-7,
0.64;
PRISMA-6,
0.75)
aligned
classifications
such
age,
status,
physical
activity.
revealed
significant
differences
but
not
Conclusions:
introduces
by
overestimating
men,
whereas
provides
consistent
findings
highlight
PRISMA-6's
reliable
tool
unbiased
screening.
Future
research
should
validate
against
established
tools
support
integration
into
primary
care
settings.
Aging Clinical and Experimental Research,
Journal Year:
2025,
Volume and Issue:
37(1)
Published: April 2, 2025
This
study
aimed
to
determine
the
relationship
among
socioeconomic
status,
social
support
and
frailty,
its
gender
difference.
Education
income
were
combined
indicate
status.
The
Social
Support
Rating
Scale
(SSRS)
was
used
measure
level
of
support.
Frailty
measured
by
FRAIL
Scale.
Mediation
effects
analyzed
using
PROCESS
4.1
macro
in
SPSS
version
26.0.
Among
936
participants,
status
had
a
direct
effect
on
frailty
(effect
=
-
0.088,
95%
CI:
0.142,
0.021).
an
indirect
pathway
for
between
0.011,
0.023,
0.003),
accounting
11.11%
total
effect.
Stratified
gender,
we
found
that
total,
significant
only
female
subsample.
Overall,
there
association
rural
older
adults,
mediated
this
relationship.
However,
differences
frailty.
Specifically,
correlation
mediating
role
public
health
sector
should
focus
adults
with
low
lack
support,
taking
targeted
interventions
avoid
delay
occurrence
progress
Journal of Bone and Joint Surgery,
Journal Year:
2024,
Volume and Issue:
106(16), P. 1512 - 1519
Published: July 2, 2024
There
is
increasing
evidence
that
musculoskeletal
tissues
are
differentially
regulated
by
sex
hormones
in
males
and
females.
The
influence
of
hormones,
addition
to
other
sex-based
differences
such
as
anatomical
alignment
immune-system
function,
impact
the
prevalence
severity
disease
well
types
injuries
affect
system
outcomes
prevention
measures
treatment.
Literature
specifically
addressing
related
limited,
underscoring
imperative
for
both
basic
clinical
research
on
this
topic.
This
review
highlights
areas
have
implications
bone
cartilage
health,
including
growth
development,
sports
injuries,
osteoarthritis,
osteoporosis,
frailty.
It
clear
important
aspects
been
understudied.
Consideration
how
hormone
therapy
will
prepuberty,
during
puberty,
adults
vital,
yet
little
known.
purpose
article
foster
awareness
interest
advancing
our
understanding
orthopaedic
practice.
Biology,
Journal Year:
2025,
Volume and Issue:
14(1), P. 92 - 92
Published: Jan. 18, 2025
This
proposed
review
aims
to
shed
light
on
the
major
genetic
and
epigenetic
contributions
ageing
process
longevity
of
individuals.
In
this
context,
we
summarize
state
knowledge
most
important
variants,
their
interactions
with
environment,
in
achieving
a
healthy
lifespan.
We
also
explore
contribution
lifestyle
influence
non-heritable
environmental
factors
(i.e.,
epigenetics).
Accordingly,
discuss
role
inflammageing
as
one
targets
overcome
morbidity
mortality
older
people
for
maintenance
ageing.
more
integrated
view
will
display
not
only
underlying
mechanisms
at
play
but
invites
reader
rethink
both
our
attitudes
toward
age.
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(7), P. 915 - 915
Published: April 2, 2025
Background/Objectives:
Frailty
screening
is
essential
in
primary
care
for
the
early
identification
of
vulnerable
older
adults.
PRISMA-7
a
widely
used
tool,
but
Item
2
("Are
you
male?")
introduces
potential
sex
bias
and
overestimates
frailty
men.
PRISMA-6,
modified
version
that
excludes
2,
might
provide
more
equitable
alternative.
This
study
evaluates
PRISMA-6's
alignment
with
Clinical
Scale
(CFS)
its
impact
on
sex-specific
classification.
Methods:
A
cross-sectional
was
conducted
142
general
practices
across
South
Tyrol,
including
9190
practice
patients
aged
≥75
years.
assessed
using
PRISMA-7,
CFS.
Correlations
between
tools
were
calculated
Kendall's
Tau-b,
whereas
Fisher's
z-test
to
compare
differences
alignment.
The
prevalence
odds
ratios
stratified
according
age.
Results:
PRISMA-6
showed
stronger
correlation
CFS
(τ
=
0.492)
than
0.308,
z
-10.2,
p
<
0.001).
effect
pronounced
men
(z
-9.8,
0.001),
no
difference
observed
women
0.00,
1.000).
reduced
detection
rate
closely
aligned
Conclusions:
demonstrated
improved
compared
PRISMA-7.
However,
use
as
tool
requires
prospective
validation
diverse
settings.
shows
promise
reliable
should
be
considered
future
studies,
particularly
settings,
while
awaiting
further
validation.
JGH Open,
Journal Year:
2025,
Volume and Issue:
9(5)
Published: May 1, 2025
ABSTRACT
Introduction
Nonvariceal
upper
gastrointestinal
bleeding
(NVUGIB)
is
a
common
cause
of
hospitalization
in
the
United
States,
with
approximately
400
000
admissions
annually
and
5%–10%
mortality
rate.
This
study
aimed
to
evaluate
frailty's
impact
on
NVUGIB
outcomes.
Methods
We
utilized
2019
National
Readmission
Database
(NRD)
identify
adult
patients
(≥
18
years)
admitted
principal
diagnosis
using
ICD‐10‐CM
codes.
hospitalizations
were
stratified
by
frailty
hospital
risk
score
(HFRS)
5
or
more
as
cut‐off
for
frailty.
Multivariate
regression
analyses
conducted
analyze
STATA
14.2
was
used
statistical
testing.
Results
Among
218
647
admissions,
99
892
(45.69%)
frail.
Frail
older,
often
female,
had
higher
comorbidity
burdens.
They
showed
significantly
greater
in‐hospital
(adjusted
odds
ratio
[aOR]
5.64,
95%
CI
4.94–6.44;
p
<
0.001),
acute
kidney
injury
(5.85),
respiratory
failure
(6.93),
septic
shock
(40.94),
hemorrhagic
(2.64),
vasopressor
use
(4.36),
mechanical
ventilation
(6.04),
ICU
admission
(5.41).
Although
frail
esophagogastroduodenoscopy
(EGD)
intervention
(1.04;
they
less
likely
receive
EGD
within
24
h
(0.75;
0.001).
also
rebleeding
(1.18;
0.001)
radioembolization
(2.69;
Length
stay
increased
2.30
days,
total
charges
rose
$28
518,
discharge
rehabilitation
frequent
(3.12;
0.01),
30‐day
readmission
(15.24%
vs.
11.43%,
HR
1.16;
Conclusion
Frailty
independently
predicts
worse
clinical
outcomes
resource
NVUGIB.
Recognizing
may
improve
stratification
guide
tailored
management
strategies
this
high‐risk
population.