Niacin Modulates SIRT1-Driven Signaling to Counteract Radiation-Induced Neurocognitive and Behavioral Impairments DOI Open Access

Erdinç Tunç,

Hatice Aygün, Mümin Alper Erdoğan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(11), P. 5285 - 5285

Published: May 30, 2025

Radiation exposure causes neuroinflammation, oxidative stress, and neuronal loss, leading to cognitive behavioral impairments. This study aims evaluate the effect of niacin interventions on whole-brain irradiation (WBI)-induced impairment. Female Wistar rats were randomly assigned Control (Group 1), +Saline 2), +niacin 3) groups. Rats in irradiated groups (Groups 2 received a single dose 20 Gy photon irradiation. Group water seven days after irradiation, while 3 (60 mg/kg, mL) oral gavage for 15 days. On 22, 23, 24, assessments performed, including Open Field Test, Sociability Passive Avoidance Learning (PAL) task. Biochemical analyses included MDA, BDNF, TNF-α, CREB), SIRT1, SIRT6 measured by ELISA. Histological density GFAP immunostaining CA1 CA3 regions hippocampus cerebellar Purkinje neurons. importantly increased MDA TNF-α levels, SIRT6, CREB notably reduced. was accompanied loss cerebellum hippocampus, astrogliosis, deficits. Niacin treatment significantly decreased levels increasing CREB, expression, attenuating apoptosis. Immunohistochemical analysis demonstrated that enhanced neurons reducing immunoreactivity CA1, CA3, following WBI. Behaviorally, improved social interaction, locomotor activity, memory performance, underscoring its neuroprotective potential against WBI-induced damage. These findings suggest may ameliorate impairments whole brain activating SIRT1/CREB/BDNF or SIRT1/SIRT6/MDA/TNF-α signaling pathway.

Language: Английский

Associations Between Dietary B Vitamin Intakes and Cognitive Function Among Elderly Individuals: An Observational Study DOI
Qinyu Chen, Jie Huang, Xiaoming Shi

et al.

Nutrition, Journal Year: 2025, Volume and Issue: 134, P. 112716 - 112716

Published: Feb. 17, 2025

Language: Английский

Citations

0
Niacin Modulates SIRT1-Driven Signaling to Counteract Radiation-Induced Neurocognitive and Behavioral Impairments DOI Open Access

Erdinç Tunç,

Hatice Aygün, Mümin Alper Erdoğan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(11), P. 5285 - 5285

Published: May 30, 2025

Radiation exposure causes neuroinflammation, oxidative stress, and neuronal loss, leading to cognitive behavioral impairments. This study aims evaluate the effect of niacin interventions on whole-brain irradiation (WBI)-induced impairment. Female Wistar rats were randomly assigned Control (Group 1), +Saline 2), +niacin 3) groups. Rats in irradiated groups (Groups 2 received a single dose 20 Gy photon irradiation. Group water seven days after irradiation, while 3 (60 mg/kg, mL) oral gavage for 15 days. On 22, 23, 24, assessments performed, including Open Field Test, Sociability Passive Avoidance Learning (PAL) task. Biochemical analyses included MDA, BDNF, TNF-α, CREB), SIRT1, SIRT6 measured by ELISA. Histological density GFAP immunostaining CA1 CA3 regions hippocampus cerebellar Purkinje neurons. importantly increased MDA TNF-α levels, SIRT6, CREB notably reduced. was accompanied loss cerebellum hippocampus, astrogliosis, deficits. Niacin treatment significantly decreased levels increasing CREB, expression, attenuating apoptosis. Immunohistochemical analysis demonstrated that enhanced neurons reducing immunoreactivity CA1, CA3, following WBI. Behaviorally, improved social interaction, locomotor activity, memory performance, underscoring its neuroprotective potential against WBI-induced damage. These findings suggest may ameliorate impairments whole brain activating SIRT1/CREB/BDNF or SIRT1/SIRT6/MDA/TNF-α signaling pathway.

Language: Английский

Citations

0