Traumatic brain injury enhances the intrinsic excitation and excitatory transmission of granule cells DOI Creative Commons
Joanna Danielewicz, Nerea Llamosas,

Irene Durá

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Abstract Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide, affecting millions people each year. TBI can lead to wide range physical cognitive impairments. It also known impact on neuronal excitability synaptic functions. Although hippocampal impairments have been widely described following TBI, the specific effects dentate gyrus (DG), which act as “gatekeeper” information processing filter excessive or aberrant input activity, remains be fully elucidated. In this study we investigated controlled cortical (CCI), model granule cells excitatory postsynaptic transmission in DG at three different time periods, 3 days, 15 day 4 months after injury. Our results indicate does not provoke changes passive membrane properties cells. By applying dimensionality reduction analysis action potential properties, were able identify variables that exhibited significant short-medium long-term changes. Indeed, observed half-width, amplitude overshoot greater points. Conversely, duration afterhyperpolarization was reduced compared control Lastly, although sEPSC did show differences among groups any point, frequency sEPCS points, follow same temporal evolution animals. These findings long term increases intrinsic excitation activity DG.

Language: Английский

Traumatic brain injury enhances the intrinsic excitation and excitatory transmission of granule cells DOI Creative Commons
Joanna Danielewicz, Nerea Llamosas,

Irene Durá

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Abstract Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide, affecting millions people each year. TBI can lead to wide range physical cognitive impairments. It also known impact on neuronal excitability synaptic functions. Although hippocampal impairments have been widely described following TBI, the specific effects dentate gyrus (DG), which act as “gatekeeper” information processing filter excessive or aberrant input activity, remains be fully elucidated. In this study we investigated controlled cortical (CCI), model granule cells excitatory postsynaptic transmission in DG at three different time periods, 3 days, 15 day 4 months after injury. Our results indicate does not provoke changes passive membrane properties cells. By applying dimensionality reduction analysis action potential properties, were able identify variables that exhibited significant short-medium long-term changes. Indeed, observed half-width, amplitude overshoot greater points. Conversely, duration afterhyperpolarization was reduced compared control Lastly, although sEPSC did show differences among groups any point, frequency sEPCS points, follow same temporal evolution animals. These findings long term increases intrinsic excitation activity DG.

Language: Английский

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