Crosstalk between the subiculum and sleep–wake regulation: A review

Journal of Sleep Research, Journal Year: 2024, Volume and Issue: 33(5)

Published: Jan. 9, 2024

Summary The circuitry underlying the initiation, maintenance, and coordination of wakefulness, rapid eye movement sleep, non‐rapid sleep is not thoroughly understood. Sleep thought to arise due decreased activity in ascending reticular arousal system, which originates brainstem awakens thalamus cortex during wakefulness. Despite conventional association sleep–wake states with hippocampal rhythms, mutual influence formation regulating vigilance has been largely neglected. Here, we focus on subiculum, main output region formation. particulary ventral part, sends extensive monosynaptic projections crucial regions implicated regulation, including thalamus, lateral hypothalamus, tuberomammillary nucleus, basal forebrain, ventrolateral preoptic tegmental area, suprachiasmatic nucleus. Additionally, second‐order from subiculum are received by laterodorsal locus coeruleus, median raphe suggesting potential involvement regulation cycle. We also discuss alterations observed individuals disorders sleep‐deprived mice, underscoring significance investigating neuronal communication between pathways promoting both

Language: Английский

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Somatic mosaicism and interneuron involvement in mTORopathies

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Transition to seizure in focal epilepsy: From SEEG phenomenology to underlying mechanisms

Epilepsia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract Objective For the pre‐surgical evaluation of patients with drug‐resistant focal epilepsy, stereo‐electroencephalographic (SEEG) signals are routinely recorded to identify epileptogenic zone network (EZN). This consists remote brain regions involved in seizure initiation. However, pathophysiological mechanisms underlying typical SEEG patterns that occur during transition from interictal ictal activity distant nodes EZN remain poorly understood. The primary aim is and explain these using a novel physiologically‐plausible model EZN. Methods We analyzed 10 activity. consisted sequence periods which neocortical showed stereotypical activity: sustained preictal spiking preceding fast occurring at onset, followed by Spectral content non‐linear correlation were analyzed. In addition, we developed neuro‐inspired computational consisting bidirectionally coupled neuronal populations. Results proposed captured essential characteristics patient signals, including quasi‐synchronous onset rapid discharges interconnected zones. Statistical analysis confirmed dynamic correlation/de‐decorrelation pattern observed accurately reproduced simulated signals. Significance study provides insight into abnormal changes glutamatergic γ‐aminobutyric acid (GABA)ergic synaptic transmission seizures. results strongly support hypothesis bidirectional connections between populations (from pyramidal cells vaso‐intestinal peptide‐positive interneurons) play key role this transition, while parvalbumin‐positive interneurons intervene emergence onset.

Language: Английский

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Impaired Response to Mismatch Novelty in the Li2+-Pilocarpine Rat Model of TLE: Correlation with Hippocampal Monoaminergic Inputs

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 631 - 631

Published: March 12, 2024

Novelty detection, crucial to episodic memory formation, is impaired in epileptic patients with mesial temporal lobe resection. Mismatch novelty that activates the hippocampal CA1 area humans and vital for reformulation reconsolidation, also lesions. In this work, we investigated response mismatch novelty, as occurs new location of known objects a familiar environment, Li2+-pilocarpine rat model TLE its correlation monoaminergic markers. Animals showing spontaneous recurrent seizures (SRSs) at least 4 weeks time behavioural testing showed spatial learning radial arm maze, described. Concurrently, SRS rats displayed exploratory responses yet novel object recognition was not significantly affected rats. While levels serotonin dopamine transporters were mildly decreased membranes from rats, on norepinephrine transporter, tyrosine hydroxylase dopamine-β-hydroxylase enhanced, hinting an augmentation, rather than impairment noradrenergic function animals. Altogether, reveals detection particularly by damage associated epilepsy 4–8 after onset SRSs suggests deficits may substantially contribute cognitive MTLE. As such, tasks based these aspects prove useful development therapy strategies aiming rescue observed epilepsy.

Language: Английский

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Impaired response to mismatch novelty in the Li2+-pilocarpine rat model of TLE: correlation with hippocampal monoaminergic inputs

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 7, 2024

Novelty detection, crucial to episodic memory formation, is impaired in epileptic patients with mesial temporal lobe resection. Mismatch novelty that activates the hippocampal CA1 area humans and vital for reformulation reconsolidation, also lesions. In this work we investigated response mismatch novelty, as occurs new location of known objects a familiar environment, Li2+-pilocarpine rat model TLE its correlation monoaminergic markers. Animals showing spontaneous recurrent seizures (SRSs) at least 4 weeks time behavioural testing showed spatial learning radial arm maze, described. Concurrently, SRSs rats displayed exploratory responses yet novel object recognition was not significantly affected rats. While levels serotonin dopamine transporters were mildly decreased membranes from SRS rats, on norepinephrine transporter, tyrosine hydroxylase dopamine-β-hydroxylase enhanced, hinting an augmentation, rather than impairment noradrenergic function animals. Altogether, reveals detection particularly by damage associated epilepsy 4-8 after onset suggests deficits may substantially contribute cognitive MTLE. As such, tasks based these aspects prove useful development therapy strategies aiming rescue observed epilepsy.

Language: Английский

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Postweaning Development Influences Endogenous VPAC1 Modulation of LTP Induced by Theta-Burst Stimulation: A Link to Maturation of the Hippocampal GABAergic System

Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 379 - 379

Published: March 20, 2024

Long-term potentiation (LTP) induced by theta-burst stimulation (TBS) undergoes postweaning developmental changes partially linked to GABAergic circuit maturation. Endogenous vasoactive intestinal peptide (VIP) acting on its VPAC1 receptor strongly influences LTP (TBS), an effect dependent transmission. Although levels are developmentally regulated during embryogenesis, their variation along development is unknown, as the modulation of or relation hippocampal As such, we investigated how adjusts from weaning adulthood with described, mild TBS (5 bursts, 4 pulses delivered at 100 Hz) was increasingly greater adulthood. The influence antagonist PG 97-269 (100 nM) TBS-induced much larger in juvenile (3-week-old) than young adult (6–7-week-old) (12-week-old) rats. This not associated a decrease synaptic levels. However, increase pre and post-synaptic markers suggests number contacts that more prominent one observed glutamatergic connections this period. Conversely, endogenous VPAC2 activation did significantly LTP. enhance pronouncedly development, but sites. Given involvement VIP interneurons several aspects hippocampal-dependent learning, neurodevelopmental disorders, epilepsy, could provide important insights into role plasticity normal altered brain potentially contributing epileptogenesis.

Language: Английский

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Postweaning development influences endogenous VPAC1 modulation of LTP induced by theta-burst stimulation: a link to maturation of the hippocampal GABAergic system?

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 19, 2024

Long-term potentiation (LTP) induced by theta-burst stimulation (TBS) undergoes postweaning developmental changes partially linked to GABAergic circuit maturation. Endogenous VIP acting on VPAC1 receptors strongly influences LTP (TBS), an effect dependent transmission. Although receptor levels are developmentally regulated during embryogenesis, its variation along development is unknow, as modulation of or relation hippocampal As such, we investigated how adjusts from weaning adulthood with described, TBS (5x4) (5 bursts, 4 pulses delivered at 100Hz) was increasingly greater adulthood. The influence the antagonist PG 97-269 (100nM) TBS-induced much larger in juvenile (3-week-old) than young-adult (6-7-week-old) adult (12-week-old) rats. This not associated a decrease synaptic levels. However, increase pre and post markers, suggests number contacts that more prominent one observed glutamatergic connections this period. Conversely, endogenous VPAC2 activation did significantly LTP. enhance pronouncedly development, but sites. Given involvement interneurons several aspects hippocampal-dependent learning, neurodevelopmental disorders, epilepsy, could provide important insights into role plasticity normal altered brain potentially contributing epileptogenesis.

Language: Английский

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