Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review DOI Creative Commons

Lebin Ke,

Yingying Cao,

Zhiwei Lü

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 9, 2024

Neurological disorders are being increasingly recognized as major causes of death and disability around the world. refer to a broad range medical conditions that affect brain spinal cord. These can have various causes, including genetic factors, infections, trauma, autoimmune reactions, or neurodegenerative processes. Each disorder has its own unique symptoms, progression, treatment options. Optimal communication between interneurons neuron-glia cells within homeostatic microenvironment is paramount importance. Within this microenvironment, exosomes play significant role in promoting intercellular by transferring diverse cargo contents, proteins, lipids, non-coding RNAs (ncRNAs). Partially, nervous system homeostasis preserved stem cell-derived exosomal ncRNAs, which include circular (circRNAs), long noncoding (lncRNAs), microRNAs (miRNAs), PIWI-interacting (piRNAs). The diversity these ncRNAs suggests their potential influence multiple pathways cellular processes system. Stem ncRNA contents been investigated for therapeutic uses neurological disorders, owing demonstrated capabilities neuroprotection, neuroregeneration, modulation disease-related pathways. ability cross blood-brain barrier makes them promising delivery vehicle ncRNAs. This review aims summarize current understanding different clinical applications.

Language: Английский

The Therapeutic Potential of MicroRNA-21 in the Treatment of Spinal Cord Injury DOI Creative Commons
Ahmed Hasan, Alessio Ardizzone, Domenico Giosa

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 70 - 70

Published: Jan. 21, 2025

Spinal cord injury (SCI) involves complex pathological processes that often result in significant and long-term neurological deficits. Increasingly, research has identified microRNA-21 (miR-21) as a pivotal regulator SCI, with studies focusing on its roles inflammation, apoptosis, tissue repair. This review synthesizes current findings miR-21’s involvement post-injury molecular events, emphasizing interactions regulatory targets such Phosphatase Tensin Homolog (PTEN) Programmed Cell Death Protein 4 (PDCD4), well broader effects inflammatory apoptotic signaling pathways. Evidence from both vitro vivo suggests modulating miR-21 influences lesion size, cellular dynamics, functional recovery, highlighting potential therapeutic target for SCI. Nonetheless, the clinical translation of miR-21-based therapies poses challenges, including need to optimize dosages, delivery mechanisms, safety profiles. Further is crucial fully delineate determine feasibility integration into SCI treatment protocols. aims provide comprehensive overview pathology, offering insights mechanisms underlying recovery emerging management enhance outcomes quality life affected patients.

Language: Английский

Citations

0
Induced Pluripotent Stem Cell-Derived Exosomes Promote Peripheral Nerve Regeneration in a Rat Sciatic Nerve Crush Injury Model: A Safety and Efficacy Study DOI Creative Commons

Fatima Aldali,

Yujie Yang, Chunchu Deng

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 529 - 529

Published: April 2, 2025

Peripheral nerve injury (PNI) remains a significant clinical challenge, often leading to long-term functional impairment. Despite advances in therapies, current repair strategies offer unsatisfactory outcomes. Exosomes derived from induced pluripotent stem cells (iPSC-Exos) have emerged as promising therapeutic approach regenerative medicine. This study assesses the efficacy and safety of iPSC-Exos rat model sciatic crush injury. Briefly, iPSCs were generated peripheral blood mononuclear (PBMCs) healthy donors using Sendai virus vectors validated for pluripotency. characterized injected at site. Functional recovery was assessed through gait analysis, grip strength, pain response. Histological molecular analyses used examine axonal regeneration, myelination, Schwann cell (SC) activation, angiogenesis, changes gene expression. efficiently internalized by SC, promoting their proliferation. No adverse effects observed between groups on body weight, organ histology, or hematological parameters. injection significantly enhanced muscle preservation, vascularization, with RNA sequencing revealing activation PI3K-AKT focal adhesion pathways. These findings support safe effective non-cell-based therapy PNIs, highlighting potential applications

Language: Английский

Citations

0
The effect of electric field microenvironment on the exosome secretion of PC12 cells by chitosan carbon dots DOI

Z.Y. Li,

Huajun Wang, Lin Zhou

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142747 - 142747

Published: April 1, 2025

Language: Английский

Citations

0
Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review DOI Creative Commons

Lebin Ke,

Yingying Cao,

Zhiwei Lü

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 9, 2024

Neurological disorders are being increasingly recognized as major causes of death and disability around the world. refer to a broad range medical conditions that affect brain spinal cord. These can have various causes, including genetic factors, infections, trauma, autoimmune reactions, or neurodegenerative processes. Each disorder has its own unique symptoms, progression, treatment options. Optimal communication between interneurons neuron-glia cells within homeostatic microenvironment is paramount importance. Within this microenvironment, exosomes play significant role in promoting intercellular by transferring diverse cargo contents, proteins, lipids, non-coding RNAs (ncRNAs). Partially, nervous system homeostasis preserved stem cell-derived exosomal ncRNAs, which include circular (circRNAs), long noncoding (lncRNAs), microRNAs (miRNAs), PIWI-interacting (piRNAs). The diversity these ncRNAs suggests their potential influence multiple pathways cellular processes system. Stem ncRNA contents been investigated for therapeutic uses neurological disorders, owing demonstrated capabilities neuroprotection, neuroregeneration, modulation disease-related pathways. ability cross blood-brain barrier makes them promising delivery vehicle ncRNAs. This review aims summarize current understanding different clinical applications.

Language: Английский

Citations

0