Exploring the Renoprotective Potential of Bioactive Nutraceuticals in Chronic Kidney Disease Progression: A Narrative Review DOI Open Access
Anindita Ghosh, Arti Muley,

Sakshi Bhat

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Chronic kidney disease (CKD) is a condition that characterized by progressive loss of function over time. A substantial increase in the burden CKD evident globally, attributed to multifactorial conditions like an expanding aging population, rising diabetes and hypertension rates, more significant exposures risk factors associated with environment lifestyle. Nutraceuticals are substances usually considered food or active part provides medical health benefits, including prevention treatment disease. The aim review positive role nutraceuticals managing CKD. narrative generated, extracting papers from databases Web Science, Scopus, ScienceDirect, ResearchGate, PubMed. Animal human trials focusing on effect different initial stage disease, i.e., stages 1, 2, 3 CKD, were included. review's outcome understanding effectiveness have shown results conditions. Active compounds include ubiquinone, curcumin, nitrates, nitrites, lycopene, resveratrol. These bioactive components also beneficial for other comorbid diabetes, hypertension, cardiovascular eminent adverse Lycopene, coenzyme Q10 (CoQ10), resveratrol, flavonoids positively impacted complications. hold great promise individuals coming years, offering diverse potential benefits. delivering vital antioxidant anti-inflammatory support alleviate oxidative stress inflammation, helping regulate blood pressure lipid levels improved health, promoting optimal renal sustain assisting maintaining electrolyte balance, warding off complications, influencing gut microbiota enhanced digestive well-being, ultimately elevating overall quality life, those

Language: Английский

Clam Peptides Attenuated Adenine-Induced Chronic Kidney Disease by Improving Inflammation, Oxidative Stress, and Intestinal Flora Composition DOI Open Access
Wenping Ren,

Qiaoni You,

Shanglong Wang

et al.

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 15

Published: March 4, 2024

Previously, we have prepared clam peptides (RBPs) that exhibited potential antihypertension and kidney protective effects in SHR rats by fermentation of Ruditapes philippinarum with Bacillus natto. In this study, established an adenine-induced chronic disease (CKD) SD investigated the improvement RBPs on CKD. The results showed compared model group, 8 weeks gavage restored structure reduced serum levels CKD-related biochemical indicators, including NGAL, CR, Ca, UA, TG, IP, L-FABP, BUN, CHO, cystatin C ( p<0.05 ). treatment also MDA, IL-1β, TGF-β1, TNF-α increased those CAT T-AOC id="M2">p<0.05 addition, intestinal microbiota analysis improved flora composition downregulating proportion Firmicutes Bacteroidetes, decreasing relative abundance Romboutsia, Ruminococcaceae_UCG-005, Christensenellaceae_R-7_group increasing Lactobacillus Muribaculaceae id="M3">p<0.05 study indicated can be used as bioactive substances marine drugs or functional foods to alleviate

Language: Английский

Citations

1
Isolation and identification of bitter peptides during sequential hydrolysis of wheat gluten by enzyme preparations with endo-and exo-activities DOI

Yunjin Wei,

Boye Liu, Hanxiao Zhang

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140491 - 140491

Published: July 23, 2024

Language: Английский

Citations

1
Exploring the Renoprotective Potential of Bioactive Nutraceuticals in Chronic Kidney Disease Progression: A Narrative Review DOI Open Access
Anindita Ghosh, Arti Muley,

Sakshi Bhat

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Chronic kidney disease (CKD) is a condition that characterized by progressive loss of function over time. A substantial increase in the burden CKD evident globally, attributed to multifactorial conditions like an expanding aging population, rising diabetes and hypertension rates, more significant exposures risk factors associated with environment lifestyle. Nutraceuticals are substances usually considered food or active part provides medical health benefits, including prevention treatment disease. The aim review positive role nutraceuticals managing CKD. narrative generated, extracting papers from databases Web Science, Scopus, ScienceDirect, ResearchGate, PubMed. Animal human trials focusing on effect different initial stage disease, i.e., stages 1, 2, 3 CKD, were included. review's outcome understanding effectiveness have shown results conditions. Active compounds include ubiquinone, curcumin, nitrates, nitrites, lycopene, resveratrol. These bioactive components also beneficial for other comorbid diabetes, hypertension, cardiovascular eminent adverse Lycopene, coenzyme Q10 (CoQ10), resveratrol, flavonoids positively impacted complications. hold great promise individuals coming years, offering diverse potential benefits. delivering vital antioxidant anti-inflammatory support alleviate oxidative stress inflammation, helping regulate blood pressure lipid levels improved health, promoting optimal renal sustain assisting maintaining electrolyte balance, warding off complications, influencing gut microbiota enhanced digestive well-being, ultimately elevating overall quality life, those

Language: Английский

Citations

0