Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Plants, Journal Year: 2024, Volume and Issue: 13(12), P. 1584 - 1584

Published: June 7, 2024

Carotenoids constitute compounds of significant biological interest due to their multiple activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and antioxidant properties. Metabolic syndrome (MetS) comprehends a series metabolic abnormalities (e.g., hypertension, obesity, atherogenic dyslipidemia) that can affect children, adolescents, the elderly. The treatment MetS involves numerous medications, which, despite efficacy, pose challenges prolonged use, high costs, various side effects. derivatives have been proposed alternative treatments because they reduce serum triglyceride concentrations, promote insulin response, inhibit adipogenesis, downregulate angiotensin-converting enzyme activity. However, carotenoids are notably sensitive pH, light exposure, temperature. This review addresses activity lycopene, lutein, fucoxanthin, astaxanthin, crocin, β-carotene towards MetS. It includes discussion sources, extraction methods, characterization techniques for analyzing carotenoids. Encapsulation approaches critically reviewed alternatives prevent degradation improve performance A brief overview physiopathology epidemiology diseases, including MetS, is also provided.

Language: Английский

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Anti-Adipogenic and Anti-Steatotic Potential of Edible Pigment Bixin and Annatto Seed Extracts: LC-MS based Bioactive Profiling and in vitro Biochemical Validation

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105893 - 105893

Published: Jan. 1, 2025

Language: Английский

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Fucoxanthin Mitigates High-Fat-Induced Lipid Deposition and Insulin Resistance in Skeletal Muscle through Inhibiting PKM1 Activity

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(32), P. 18013 - 18026

Published: Aug. 1, 2024

Glucose and lipid metabolism dysregulation in skeletal muscle contributes to the development of metabolic disorders. The efficacy fucoxanthin alleviating disorders remains poorly understood. In this study, we systematically investigated impact on mitigating deposition insulin resistance employing palmitic acid-induced C2C12 cells ob/ob mice. Fucoxanthin significantly alleviated PA-induced resistance. addition, prominently upregulated expression metabolism-related genes (Pparα Cpt-1), promoting fatty acid β-oxidation metabolism. Additionally, increased Pgc-1α Tfam, elevated mtDNA/nDNA ratio, reduced ROS levels. Further, identified pyruvate kinase isozyme 1 (PKM1) as a high-affinity protein for by drug affinity-responsive target stability LC–MS confirmed their robust interaction CETSA, microscale thermophoresis, circular dichroism. Supplementation with pyruvate, product PKM1, attenuated beneficial effects Mechanistically, glucose glycolysis rate enhanced mitochondrial biosynthesis through inhibiting PKM1 activity, thereby stress. These findings present novel clinical strategy treating diseases using fucoxanthin.

Language: Английский

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Kelp nanocellulose combined with fucoxanthin achieves lipid-lowering function by reducing oxidative stress with activation of Nrf2/HO-1/NQO1 pathway

Food Chemistry, Journal Year: 2024, Volume and Issue: 464, P. 141588 - 141588

Published: Oct. 9, 2024

Language: Английский

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