A soluble garlic polysaccharide supplement alleviates fatigue in mice DOI Creative Commons
Tianyi Li, Chanyuan Xie,

Zhenyang Tian

et al.

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: Nov. 21, 2024

Garlic polysaccharide (GP) is an inulin-type fructan with potent antioxidant activity, whereas its health-promoting functions are not well explored. In the current study, we established a fatigue model by forcing mice to swim in water tank for at least one hour every day. We measured changes body weight, exhaustive swimming time, and biochemical indices related weight-bearing fed low (1.25 g/kg-BW) high doses (2.5 of GP daily gavage 7 weeks. The soluble was extracted from industrial garlic wastes using patented method. results indicate that improved symptoms increasing duration swimming, restoring blood markers (BUN BLA), liver muscle glycogen reserves fatigued mice. also increased enzyme activity (SOD, GSH-Px, CAT) restored ATPase activating AMPK/PGC-1α pathway. Additionally, modified gut microbiota potentially beneficial bacteria decreasing harmful bacteria. increase Bacteroidota decrease Firmicutes phyla regulate metabolism short-chain fatty acids gut. conclusion, may be effective alleviating exercise-induced through multiple mechanisms can developed into health anti-fatigue supplements.

Language: Английский

Ethyl acetate extract from Herpetospermun cardigerum Wall. Ameliorated Concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways DOI
Xiao Yu, Tao Luo,

Changsong Duan

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119578 - 119578

Published: March 1, 2025

Language: Английский

Citations

0
Flammulina velutipes residue Polysaccharide Alleviates Immunosuppression and Intestinal Injury by Modulating Gut Microbiota and Associated Metabolites DOI
Yiting Yang, Yao Zhang, Wenying Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

This study elucidated the mechanisms underlying immunoregulatory and gut-microbiota-modulating effects of Flammulina velutipes residue polysaccharide (FVRP) using cyclophosphamide (CTX)-induced mouse models. FVRP supplementation alleviated CTX-induced intestinal damage boosted antioxidant enzyme activity cytokine secretion. Additionally, enhanced diversity total species richness gut microbiota, promoting proliferation beneficial bacteria (e.g., Prevotellaceae), while reducing abundance CTX-derived (Lachnospiraceae Rikenellaceae). facilitates accumulation short-chain fatty acids. Untargeted metabolomic analyses cecal content revealed that treatment notably restored levels 32 endogenous metabolites altered by CTX. Based on a pseudosterility mice model, fecal microbiota transplantation (FMT), filtrate (FFT), associated were demonstrated to play crucial role in immunomodulatory protective against injury. In conclusion, exhibits significant potential as an immune enhancer natural therapeutic agent for alleviating inflammatory conditions.

Language: Английский

Citations

0
The protective effect of Auricularia auricula polysaccharides on cyclophosphamide-induced immunosuppression and intestinal injury: A fecal microbiota transplantation study DOI
Tianci Wang,

Zikun Jia,

Canghai An

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105416 - 105416

Published: Nov. 5, 2024

Language: Английский

Citations

2
The intestinal mucosal immunity in mice enhanced by crosslinked ready-to-eat sea cucumber via regulating the SIgA secretion and gut microbiota DOI

Lulu Zhu,

Yuqian Meng,

Yuhan Zhao

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104282 - 104282

Published: May 9, 2024

Language: Английский

Citations

1
Sea Cucumber Intestinal Osteotropic Peptide Promotes Tibial Fracture Healing in Osteoporotic Mice by Promoting Glutamine Metabolism DOI

Haowen Yin,

Sun Jin Hur, Tianqi Zhang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104370 - 104370

Published: Aug. 1, 2024

Language: Английский

Citations

1
A systematic review of preclinical studies targeted toward the management of co-existing functional gastrointestinal disorders, stress, and gut dysbiosis DOI
Shreyashi Pal,

Ruhi Arisha,

Papiya Mitra Mazumder

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 25 - 46

Published: Aug. 3, 2024

Language: Английский

Citations

1
Integrated metabolome and transcriptome revealed the metabolite profiles and regulatory network during tea tree (Camellia sinensis) seed maturation DOI

Jiaxin Kang,

Ziyi Han,

Mengxin Huang

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 220, P. 119214 - 119214

Published: July 18, 2024

Language: Английский

Citations

1
Stability of oil‐in‐water emulsion and immunomodulating activity in S180 tumor‐bearing mice DOI
Yanying Zhang,

Jingning Dong,

Feifei Wang

et al.

Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(9), P. 5884 - 5899

Published: Aug. 16, 2024

Abstract The stability and nutritional integrity of emulsions are susceptible to various factors including thermal treatment, solid–liquid ratio, sterilization. In this study, the physicochemical immunomodulatory activities an oil‐in‐water emulsion containing immune peptides (TUFSE) were assessed through particle size, zeta potential, related cytokines, so on. When temperature was 70°C a ratio 1:4, revealed at high‐pressure homogenization, with small size. loss rates vitamins 8.57%–62.26% in 6 months 25°C. After treatment cyclophosphamide (CTX), lymphocyte proliferation activity TUFSE‐H group increased ( p < 0.05), globulin levels notably elevated 0.05) TUFSE groups compared model group. It confirms parameters emulsion, suggesting its ability be prepared minimal vitamin while simultaneously improving disease status CTX‐treated tumor‐bearing mice. shows potential as immune‐enhancing supplement significant value. Practical Application This study validated showed that it can stably minor exhibited notable increase lymphocytes activity, whereas serum cytokines MC group, indicating substantial

Language: Английский

Citations

0
A soluble garlic polysaccharide supplement alleviates fatigue in mice DOI Creative Commons
Tianyi Li, Chanyuan Xie,

Zhenyang Tian

et al.

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: Nov. 21, 2024

Garlic polysaccharide (GP) is an inulin-type fructan with potent antioxidant activity, whereas its health-promoting functions are not well explored. In the current study, we established a fatigue model by forcing mice to swim in water tank for at least one hour every day. We measured changes body weight, exhaustive swimming time, and biochemical indices related weight-bearing fed low (1.25 g/kg-BW) high doses (2.5 of GP daily gavage 7 weeks. The soluble was extracted from industrial garlic wastes using patented method. results indicate that improved symptoms increasing duration swimming, restoring blood markers (BUN BLA), liver muscle glycogen reserves fatigued mice. also increased enzyme activity (SOD, GSH-Px, CAT) restored ATPase activating AMPK/PGC-1α pathway. Additionally, modified gut microbiota potentially beneficial bacteria decreasing harmful bacteria. increase Bacteroidota decrease Firmicutes phyla regulate metabolism short-chain fatty acids gut. conclusion, may be effective alleviating exercise-induced through multiple mechanisms can developed into health anti-fatigue supplements.

Language: Английский

Citations

0