Published: Jan. 1, 2024
Language: Английский
Published: Jan. 1, 2024
Language: Английский
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122691 - 122691
Published: Aug. 30, 2024
Language: Английский
Citations
5Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106687 - 106687
Published: Jan. 23, 2025
Language: Английский
Citations
0Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 11, 2025
Preterm birth (PTB) is a major cause of infant morbidity and mortality. The aim this study was to investigate the effect vaginal microbiota metabolites on outcome pregnant women. In study, total 127 women provided written informed consent prior enrollment in accordance with approved institutional guidelines, but only 45 pregnancies met experimental requirements, then blood cervical fluid (CVF) samples were collected before delivery (at second week after cerclage). Pregnant PTB exhibited high white cell neutrophil contents, neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI) blood. Vaginal microbiome revealed that proportion beneficial bacteria (including Lactobacillus , [ Ruminococcus ] gnavus group Megamonas ) significantly decreased group, harmful Desulfovibrionaceae Helicobacter Gardnerella increased, which strongly related biochemical parameters (white cells, neutrophils, NLR, SIRI). addition, metabolomics-based liquid chromatography–Orbitrap–tandem mass spectrometry (LC-Orbitrap-MS/MS) found alteration involved starch sucrose metabolism; arginine praline galactose purine tryptophan metabolism N-glycan biosynthesis; cysteine methionine taurine hypotaurine amino acid propanoate valine, leucine, isoleucine glycine, serine, threonine steroid hormone biosynthesis. These results elaborated distinct metabolome profiles preterm following cerclage provide valuable information for establishing prediction models PTB.
Language: Английский
Citations
0Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: March 17, 2025
Preterm birth is a major cause of perinatal morbidity and mortality. The disruption vaginal microbiota in pregnant women the most significant risk factor for preterm delivery. In this study, 65 were enrolled, which 29 with term births 36 births, then categorized based on gestational age at results showed that α-diversity (ACE, Chao1, Simpson, Shannon indices) group (TG) was significantly higher than (PG). relative abundance beneficial bacteria (e.g., Lactobacillus) reduced PG compared to TG, while harmful Gardnerella, Atopobium, Ralstonia, Sneathia) increased. A prediction model delivery established key microbial phylotypes, further verified using clinical samples. Statistical analysis revealed utilizing Methyloversatilis, Sneathia, Brevundimonas, Acinetobacter, Peptostreptococcus had accuracy. These suggest certain could serve as prospective predictors provide theoretical basis treatment birth.
Language: Английский
Citations
0Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106834 - 106834
Published: April 21, 2025
Language: Английский
Citations
0International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138400 - 138400
Published: Dec. 1, 2024
Language: Английский
Citations
3Published: Jan. 1, 2024
Language: Английский
Citations
0