Akebia trifoliata extracts attenuate liver injury via gut–liver axis in a murine model of nonalcoholic fatty liver disease with low-grade colitis

Food Research International, Journal Year: 2025, Volume and Issue: 208, P. 116202 - 116202

Published: March 15, 2025

Language: Английский

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Pandanus Amaryllifolius Roxb. Polyphenol Extract Alleviates NAFLD via Regulating Gut Microbiota and AMPK/AKT/mTOR Signaling Pathway

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 1000 - 1000

Published: March 15, 2025

With the drastic changes in lifestyle, nonalcoholic fatty liver disease (NAFLD) has become a widespread health problem. Natural actives such as polyphenols have multi-target, multi-mechanism characteristics, and offer new opportunities for NAFLD treatment. This study established high-fat diet (HFD)-induced model mice to investigate molecular mechanism of Pandanus amaryllifolius Roxb. polyphenol extract (PAE) alleviating NAFLD. The results showed that PAE significantly inhibited HFD-induced obesity, maintained glucose homeostasis, mitigated oxidative damage tissue, reduced steatosis. Moreover, treatment remarkably reversed 16 endogenous DMs, affected glycerophospholipid metabolism, which increased levels phosphatidylcholine phosphatidylethanolamine, down-regulated choline sn-glyceropl-3P. Further validation revealed was able prevent progression by regulating AMPK/AKT/mTOR signaling pathway enhance autophagy levels. Meanwhile, restored balance gut microbiota mainly increasing relative abundance Bacteroidetes, decreasing Firmicutes ratio Firmicutes/Bacteroidetes. Overall, findings highlight alleviates may be related regulation microbes pathway, enriching health-promoting effects on

Language: Английский

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Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 22, 2025

Abstract Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, characterized by range metabolic and complications, including insulin resistance, hyperandrogenism, menstrual irregularities. The complexity PCOS necessitates innovative therapeutic strategies that extend beyond conventional pharmacological treatments. Main body Ursolic acid (UA), natural pentacyclic triterpenoid found in various plants, has gained significant attention for its diverse properties anti-inflammatory, antioxidant, anticancer, antidiabetic, antimicrobial, antihyperlipidemic, anti-obesity, neuroprotective, hepatoprotective, cardioprotective activities. Additionally, the integration predictive tools, such as artificial intelligence bioinformatics databases like STRING (Search Tool Retrieval Interacting Genes/Proteins) KEGG (Kyoto Encyclopedia Genes Genomes), allows identification key protein targets pathways influenced UA, TP53 (Tumor Protein P53), AR (Androgen Receptor), ESR1 (Estrogen Receptor 1), BCL2 (B-cell Lymphoma 2), STAT3 (Signal Transducer Activator Transcription 3), IL6 (Interleukin 6). These are crucial inflammatory regulation have been linked to symptoms PCOS. Further silico studies were conducted validate these findings, highlighting need additional preclinical clinical research. Conclusion Comprehensive guidelines effective use UA managing warranted ensure optimal treatment strategies.

Language: Английский

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Mechanistic study of a triterpenoid-enriched fraction derived from Cynomorium songaricum against NAFLD: An integrative elucidation

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156782 - 156782

Published: April 24, 2025

Language: Английский

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Pharmacological and therapeutic effects of natural products on liver regeneration-a comprehensive research

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 6, 2025

Abstract Liver regeneration (LR) refers to the physiological process by which hepatocytes undergo cellular proliferation restore structure and function of liver following significant hepatocyte loss due injury or partial hepatectomy (PH). While possesses a remarkable regenerative capacity, this is tightly regulated ensure appropriate cessation once homeostasis reestablished. Various strategies, including technological interventions pharmacological agents, have been explored enhance LR. Among these, natural products emerged as promising candidates for promoting For instance, quercetin, compound, has shown LR PH maintaining redox stimulating proliferation. However, present certain limitations, such poor solubility low bioavailability, may hinder their clinical application. Modifications in formulation mode administration demonstrated potential overcoming these challenges optimizing effects. Recent advancements research further highlighted growing relevance products, traditional Chinese medicine (TCM), context Despite progress, comprehensive systematic review roles, mechanisms, therapeutic remains lacking. This aims bridge gap summarizing with promote Drawing on data from PubMed, Web Science, CNKI databases, it elucidates effects regulatory providing valuable reference future application field

Language: Английский

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Resistant starch type 1 and 2 macromolecules from giant swamp taro (Cyrtosperma merkusii): A potential solution for lipid metabolism–regulating strategies

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144193 - 144193

Published: May 1, 2025

Language: Английский

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Schisandrin A alleviates non-alcoholic fatty liver disease by improving liver metabolic disorders and suppressing the GSK3β signaling pathway

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105245 - 105245

Published: Oct. 1, 2024

Language: Английский

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