The Health Benefits and Functional Properties of Gochujang: A Comprehensive Review of Fermentation and Bioactive Compounds

Fermentation, Journal Year: 2025, Volume and Issue: 11(2), P. 67 - 67

Published: Feb. 1, 2025

Gochujang, a traditional Korean fermented red pepper paste, is celebrated for its unique spicy and flavor. This natural, whole food offers several health benefits due to the bioactive compounds formed during fermentation diverse ingredients. These have been shown anti-cancer properties anti-inflammatory effects by reducing inflammatory cytokines suppressing pathways associated with diseases such as colitis hepatitis. Gochujang has also help prevent obesity promoting weight loss, inhibiting fat accumulation, improving lipid profiles. It aid in prevention of diabetes hepatic glucose production insulin sensitivity. The influence gochujang on gut microbiota remarkable, ability increase beneficial bacteria, improve microbial balance, alleviate metabolic disorders. primary agents responsible these are capsaicin, by-products, other compounds. process, driven microorganisms, enhances nutritional functional gochujang, strengthening health-promoting potential. paper provides comprehensive review gochujang’s historical background, methods, role microorganisms fermentation, properties, emphasizing value overall improvement.

Language: Английский

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Arecoline Alleviates T2DM via Gut Microbiota Modulation and Liver Gene Regulation in Mice

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT Scope Arecoline, the main alkaloid in areca nut, has shown potential modulating metabolism and gut microbiota. This study aimed to evaluate its therapeutic effects on glucose lipid metabolism, inflammation, liver function, mechanisms a Type 2 diabetes mellitus (T2DM) mouse model. Methods results T2DM was established mice with high‐fat, high‐sugar diet, streptozotocin injections. Arecoline significantly reduced fasting blood glucose, enhanced tolerance, increased insulin sensitivity. Serum profiles showed marked decreases total cholesterol, triglycerides, LDL‐C levels. Systemic as measured by serum levels of IL‐1β, IL‐6, MCP‐1, decreased significantly. Improvements function were observed, indicated reductions ALT AST Liver transcriptomic analysis revealed modulation pathways related glutathione MAPK signaling, cAMP which involved signaling oxidative stress response. Additionally, arecoline mitigated dysbiosis restoring microbial diversity, altering microbiota composition, regulating key NAD biosynthesis fatty acid β‐oxidation, critical for maintaining energy homeostasis. Conclusion improves profiles, while metabolic pathways, showing agent T2DM.

Language: Английский

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Self-assembly of phosphorylated capsaicin and curcumin for treatment of triple-negative breast cancer via combination of chemotherapy and photodynamic therapy

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 137108 - 137108

Published: May 1, 2025

Language: Английский

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Efficacy and Mechanism of Schisandra chinensis Fructus Water Extract in Alzheimer’s Disease: Insights from Network Pharmacology and Validation in an Amyloid-β Infused Animal Model

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3751 - 3751

Published: Oct. 31, 2024

Fructus (SCF) is a traditional medicinal herb containing lignans that improves glucose metabolism by mitigating insulin resistance. We aimed to investigate the therapeutic potential and action mechanism of SCF for Alzheimer's disease (AD) using network pharmacology analysis, followed experimental validation in an AD rat model.

Language: Английский

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Special Issue: “Gut Microbiota and Nutrition in Human Health”

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11589 - 11589

Published: Oct. 29, 2024

The microbiome is a singular term for vast array of life forms that live symbiotically within the bodies human and animal hosts, forming commensal, parasitic, or mutualistic relationships [...]

Language: Английский

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