Cited by Trilobatin as a potential adjuvant therapy for NAFLD: Targeting AMPK-PPARα and Nrf2 antioxidant pathways

Passion Fruit Seed Extract Attenuates Hepatic Steatosis in Oleic Acid-Treated HepG2 Cells through Modulation of ERK1/2 and Akt Signaling Pathways DOI

Furoida Moolsup,

Wiwit Suttithumsatid,

Wanwipha Woonnoi

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

Biological Activities and Phytochemical Profile of Hawm Gra Dang Ngah Rice: Water and Ethanolic Extracts DOI

Suchanat Chaithong,

Pinwadee Sukkarn,

Chakkapat Aenglong

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1119 - 1119

Published: March 24, 2025

Hawm Gra Dang Ngah rice (HDNR) is a red variety cultivated in Thailand's southern border region, yet its biological properties have not been extensively studied. This study investigates the effects of HDNR extracts on bioactive constituents, spectral fingerprints, and antioxidant capacities. We evaluated inhibitory aqueous (HDNR-W) ethanolic (HDNR-E) monoamine oxidase (MAO), α-glucosidase, HMG-CoA reductase activities, as well their cytotoxicity normal cancer cells. The results demonstrated that HDNR-E contained significantly higher concentrations phenolic compounds, flavonoids, anthocyanins compared to HDNR-W. In contrast, HDNR-W exhibited greater amino acid content than HDNR-E. FT-IR analysis revealed solvent-specific interactions influenced compound solubility, highlighting distinct extraction efficiencies. Antioxidant assays showed be markedly more potent, with superior performance DPPH, ABTS, metal chelation, FRAP assays, evidenced by lower IC50 values relative Furthermore, displayed stronger activity against both MAO α-glucosidase Conversely, efficacy toward significant antiproliferative A549 lung MCF-7 breast cells without affecting These highlight potential valuable source compounds underscore importance solvent selection enhancing health benefits extracts.

Language: Английский

Citations

Sangyod Rice Extract Attenuates Vascular Inflammation and Injury in a Rat Model of Diabetes by Modulating the Akt/MAPK Signaling Pathway DOI

Wanwipha Woonnoi,

Kornsuda Thipart,

Wanthanee Hanchang

et al.

Advances in Pharmacological and Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Our previous study has shown the beneficial effect of ethanolic extract Sangyod rice (SE) on lipid accumulation and insulin resistance. However, its vascular inflammation yet to be explored. The current aimed investigate anti‐inflammatory effects SE in both vitro vivo models, specifically examining impact LPS‐induced RAW264.7 cells evaluating efficacy an animal model diabetes mellitus induced by a high‐fat diet combined with low‐dose streptozotocin. In experiments, treatment effectively suppressed activation key signaling pathways, including Akt, ERK1/2, p38 MAPK, NF‐κB, which are known play pivotal roles inflammatory response. was also found reduce oxidative stress production markers LPS‐stimulated cells. administration (500 mg/kg BW) metformin (200 diet/streptozotocin‐induced diabetic rats improved dyslipidemia, as evidenced reductions serum total cholesterol, LDL‐cholesterol, triglycerides compared untreated control group. Importantly, ameliorated damage endothelium elastic fibers downregulating expression proinflammatory cytokines markers. Additionally, attenuated upregulation associated ER stress‐mediated apoptotic comparable those observed treated standard antidiabetic drug metformin. These findings suggest that possesses protective properties, evident studies.

Language: Английский

Citations

Trilobatin as a potential adjuvant therapy for NAFLD: Targeting AMPK-PPARα and Nrf2 antioxidant pathways DOI

Jinghao Zhao,

Xiaoyu Zhang,

Shang Shi

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 63, P. 105598 - 105598

Published: Dec. 3, 2024

Language: Английский

Citations