Antioxidant Activity of Anthocyanins and Anthocyanidins: A Critical Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12001 - 12001

Published: Nov. 8, 2024

Anthocyanins are the main plant pigments responsible for color of flowers, fruits, and vegetative organs many plants, applied also as safe food colorants. They efficient antioxidants. In this review, reactivity anthocyanins their aglycones, anthocyanidins, in antioxidant assays, reactions with reactive oxygen nitrogen species, effects interactions other compounds metal ions on activity electrochemical properties presented. Numerous cases attenuation oxidative stress at cellular organismal levels by cited. The direct indirect action anthocyanins, question specificity anthocyanin complex extracts, well limitations vitro assays biomarkers used detection critically discussed.

Language: Английский

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Natural remedies proposed for the management of diabetic retinopathy (DR): diabetic complications

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Abstract Diabetic retinopathy (DR) represents a significant and serious complication associated with diabetes mellitus (DM), often resulting in considerable visual impairment or even blindness. The intricate pathological processes underlying DR complicate the effectiveness of current treatment modalities. Studies have highlighted potential natural products via several beneficial effects including anti-inflammatory, antioxidant, anti-neovascular, anti-apoptotic properties. Flavonoids, saponins, saccharides, alkaloids exhibited various vivo vitro studies. However, clinical utilization these compounds is hindered by issues such as inadequate specificity, low bioavailability, toxicity. Therefore, there pressing need for rigorous studies to confirm efficacy preventing mitigating progression DR.

Language: Английский

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Blueberry Anthocyanin Extracts (BAEs) Protect Retinal and Retinal Pigment Epithelium Function from High-Glucose-Induced Apoptosis by Activating GLP-1R/Akt Signaling

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Diabetic retinopathy is a severe diabetes complication leading to vision impairment and blindness primarily due the disruption of insulin signaling in retina. This study investigated protective effects blueberry anthocyanin extracts (BAEs) its main component, anthocyanin-3-glucoside (C3G), retinas diabetic mice ARPE-19 cells under high-glucose (HG) conditions. The results showed that suffered significant weight loss, elevated glycemic levels, increased retinal cell apoptosis after 10 weeks. Treatment with various doses BAEs resulted reduction stabilization, decreased levels inflammatory cytokines, inhibition apoptosis. These findings suggested possess hypoglycemic properties, potentially mitigating diabetes-induced damage by modulating associated pathways. Immunoblotting analysis revealed persistent hyperglycemia impaired Akt/GSK3β pathway mice, while high significantly restored function these pathways promoted GLP-1 release, enhancing GLP-1R expression retina injury. Finally, studies on C3G models deficient REDD1 HG conditions protected from through GLP-1R/Akt pathway. In conclusion, this research provides valuable insights into therapeutic potential for managing diabetes-related ocular complications.

Language: Английский

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Protective Effects of Purple Corn (Zea mays L.) Byproduct Extract on Blue Light-Induced Retinal Damage in A2E-Accumulated ARPE-19 Cells

Preventive Nutrition and Food Science, Journal Year: 2024, Volume and Issue: 29(3), P. 376 - 383

Published: Sept. 30, 2024

This study investigated the antioxidative characteristics of

Language: Английский

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