International Immunopharmacology, Journal Year: 2023, Volume and Issue: 126, P. 111297 - 111297
Published: Nov. 30, 2023
Language: Английский
South African Journal of Chemical Engineering, Journal Year: 2024, Volume and Issue: 48, P. 184 - 193
Published: Feb. 6, 2024
This paper reports the ability of chitosan-reduced graphene oxide (rGO) modified electrode as a sensitive layer working in detecting formaldehyde. The substrate is form copper-SPE which has been shaped into 5 mm area. On top electrode, number chitosan and matrices were placed thin film that works electrode. Characterization films was done using SEM, TEM, AFM FTIR. test for electrochemical sensing observed cyclic voltammetry (CV), whereas chitosan-rGO deposited onto surface electrodes. novelty this research utilization based testing results showed sensitivity response increased when used formaldehyde detection compared to It proven from value at lowest 4.6 × 10−4 µA/µM linear range 1-12 µM/L, well worked limit (LoD) 0.36 µM/L quantification (LoQ) 1.21 µM/L.
Language: Английский
Citations
5
iScience, Journal Year: 2024, Volume and Issue: 27(4), P. 109358 - 109358
Published: March 5, 2024
Mesenchymal stem cell (MSC)-mediated coupling of osteogenesis and angiogenesis is a critical phenomenon in bone formation. Herein, we investigated the role mechanism SGMS1 osteogenic differentiation MSCs and, combination with angiogenesis, to discover new therapeutic targets for skeletal dysplasia defects. addition accelerated MSC differentiation, whereas silencing suppressed this process. Moreover, overexpression inhibited ceramide (Cer) promoted sphingomyelin (SM) levels. SM treatment neutralized suppressive effect shSGMS1 on osteogenesis. restrained PP2A activity by regulating Cer/SM metabolism thus enhanced levels phosphorylated Akt, Runx2, vascular endothelial growth factor (VEGF). Furthermore, transcription was regulated Runx2. increased MSC-mediated promoting VEGF expression. rat regeneration vivo. In conclusion, induces osteogenic-angiogenic through regulation Cer/PP2A/Akt signaling pathway.
Language: Английский
Citations
5
The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 985, P. 179752 - 179752
Published: May 27, 2025
Language: Английский
Citations
0
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(14)
Published: July 1, 2024
Abstract Long non‐coding RNAs (lncRNAs) have emerged as crucial regulators in the central nervous system, yet their role vestibular compensation remains elusive. To address this knowledge gap, we employed unilateral labyrinthectomy (UL) rats to establish animal models of peripheral dysfunction. Utilizing ribonucleic acid sequencing (RNA‐seq), comprehensively analysed expression profiles genes dysregulated medial nucleus (MVN) these at distinct time points: 4 h, days, and 14 days post‐UL. Through trans‐target prediction analysis integrating differentially co‐expressed messenger (mRNAs) lncRNAs, constructed lncRNA‐mRNA regulatory networks. Validation selected mRNAs lncRNAs was performed using RT‐qPCR. Our RNA‐seq revealed significant aberrant 3054 1135 compared control samples. By applying weighted gene co‐expression network (WGCNA), identified 11 modules encompassing all genes. Notably, within MEmagenta module, observed an initial upregulation expressed (DEGs) followed by downregulation 4‐ 14‐days findings indicated that 3068 positively regulated 1259 DEGs, while 1482 negatively 433 DEGs MVN. The RT‐qPCR results corroborated data, validating our findings. This study offers novel insights into landscape during compensation, paving way for further exploration lncRNA functions context.
Language: Английский
Citations
1
International Immunopharmacology, Journal Year: 2023, Volume and Issue: 126, P. 111297 - 111297
Published: Nov. 30, 2023
Language: Английский
Citations
0