The
assessment
of
neurotoxic
effects
lead,
cadmium,
mercury,
and
arsenic
mixture
(MIX)
administered
at
environmentally
relevant
low
doses,
was
conducted
using
both
in
vivo
silico
approaches.
A
subacute
study
on
a
rat
model
(number
animals
per
group:
5),
consisting
control
five
treatment
groups
subjected
to
oral
exposure
with
gradually
increasing
doses
(from
MIX
1
5).
Behavioral
tests
were
the
last
day,
brain
tissue
examined
for
oxidative
stress,
pathohistological
changes
acetylcholinesterase
(AChE)
activity.
Low
did
not
affect
spontaneous
locomotor
activity
(SLA),
but
highest
dose
showed
tendency
memory
impairment
(NORT).
Dose-response
analysis
indicated
that
even
concentrations
toxic
metals
can
cause
damage
(Benchmark
methodology).
2
imbalance
most
narrow
BMDI
detected
superoxide
dismutase
falling
within
range
1e-06
3.18e-05
mg
As/kg
b.w./day.
Pathohistological
alterations
severe
5
group.
In
(Comparative
Toxicogenomics
Database)
predicted
reduction
AChE
by
MIX.
This
prediction
subsequently
validated
an
experiment,
demonstrating
dose-dependent
decrease.
current
highlights
vulnerability
mature
minimal
amounts
investigated
metal
mixture,
particularly
context
early
onset
cholinergic
susceptibility
higher
doses.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
287, P. 117315 - 117315
Published: Nov. 1, 2024
Lead
(Pb),
mercury
(Hg),
and
cadmium
(Cd)
are
prevalent
persistent
environmental
contaminants,
causing
detrimental
effects
on
millions
of
individuals
worldwide.
Our
previous
research
demonstrated
that
early-life
exposure
to
low-level
Pb,
Hg,
Cd
mixtures
may
lead
cognitive
impairments.
However,
the
association
interaction
among
low
levels
or
remains
unclear.
In
this
study,
a
two-level
full
factorial
design
(5.481,
0.036,
2.132
mg/L
for
respectively)
was
conducted
assess
interplay
maternal
offspring
cognition.
Following
during
pregnancy
lactation,
competitive
absorption
observed.
Maternal
each
metal
alone
resulted
in
higher
blood
brain
concentrations
compared
co-exposure
at
equivalent
levels.
behavioral
experiments
Morris
water
maze
novel
object
recognition
test
revealed
synergistically
impaired
offspring's
spatial
cognition
memory.
Importantly,
dysfunction
persisted
into
middle
age
even
without
after
adulthood.
Moreover,
open
field
elevated
plus
indicated
triggered
risk-taking
behavior
weaning
offspring,
with
significant
main
effect
Pb
exposure.
No
long-lasting
detected
middle-aged
offspring.
Further
investigation
molecular
mechanisms
showed
dysregulation
corticosterone
reaction
immune
response
might
be
potential
mechanism
underlying
co-exposure-induced
study
highlights
synergistic
multiple
heavy
exposures,underscoring
urgency
prevent
children
women
childbearing
age.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
264, P. 115425 - 115425
Published: Sept. 1, 2023
Lead
(Pb),
cadmium
(Cd),
and
mercury
(Hg)
are
environmentally
toxic
heavy
metals
that
can
be
simultaneously
detected
at
low
levels
in
the
blood
of
general
population.
Although
our
previous
studies
have
demonstrated
neurodevelopmental
toxicity
upon
co-exposure
to
these
levels,
precise
mechanisms
remain
largely
unknown.
Dendritic
spines
structural
foundation
memory
undergo
significant
dynamic
changes
during
development.
This
study
focused
on
dynamics
dendritic
brain
development
following
Pb,
Cd,
Hg
co-exposure-induced
impairment.
First,
characteristics
prefrontal
cortex
were
observed
throughout
life
cycle
normal
rats.
We
increased
rapidly
from
birth
their
peak
value
weaning,
followed
by
pruning
a
decrease
adolescence.
tended
stable
until
loss
old
age.
Subsequently,
rat
model
low-dose
embryo
adolescence
was
established.
The
results
showed
exposure
doses
equivalent
those
population
impaired
spatial
altered
spine
weaning
Proteomic
analysis
samples
suggested
differentially
expressed
proteins
metal
enriched
spine-related
cytoskeletal
regulation
axon
guidance
signaling
pathways
cofilin
both
pathways.
Further
experiments
confirmed
actin
cytoskeleton
disturbed
pruning-related
LIM
domain
kinase
1-cofilin
pathway
cortex.
Our
findings
demonstrate
may
promote
impairment
perturbing
through
Annals of Occupational and Environmental Medicine,
Journal Year:
2023,
Volume and Issue:
35(1)
Published: Jan. 1, 2023
Exposure
to
heavy
metals
is
a
public
health
concern
worldwide.
Previous
studies
on
the
association
between
metal
exposure
and
neurobehavioral
functions
in
children
have
focused
single
exposures
clinical
manifestations.
However,
present
study
evaluated
effects
of
complex
subclinical
function
using
Korean
Computerized
Neurobehavior
Test
(KCNT).Urinary
mercury,
lead,
cadmium
analyses
as
well
symbol
digit
substitution
(SDS)
choice
reaction
time
(CRT)
tests
KCNT
were
conducted
aged
10
12
years.
Reaction
urinary
levels
analyzed
partial
correlation,
linear
regression,
Bayesian
kernel
machine
regression
(BKMR),
weighted
quantile
sum
(WQS)
G-computation
analysis.Participants
203
SDS
198
CRT
analyzed,
excluding
poor
cooperation
inappropriate
urine
sample.
Partial
correlation
analysis
revealed
no
individual
metals.
The
result
multiple
shows
significant
positive
CRT.
BMKR,
WQS
showed
statistically
concentrations,
especially
lead
time.Assuming
exposures,
concentrations
with
These
results
suggest
that
during
childhood
should
be
managed
strictly.
