Toxicology Reports,
Journal Year:
2024,
Volume and Issue:
14, P. 101859 - 101859
Published: Dec. 10, 2024
Acrylamide
(AA)
has
raised
concerns
throughout
the
world
in
recent
years
because
of
its
potential
negative
effects
on
human
health.
Numerous
researches
humans
and
animals
have
connected
a
high
dietary
exposure
to
AA
possible
risk
cancer.
Additionally,
higher
consumption
acrylamide
also
been
associated
with
dysfunctioning
various
organ
systems
from
nervous
system
reproductive
system.
is
primarily
metabolised
into
glycidamide
inside
body
which
gets
accumulated
different
tissues
including
kidney
liver,
chronic
this
can
lead
nephrotoxicity
hepatotoxicity
through
molecular
mechanisms.
This
review
summarizes
sources,
formation
metabolism
along
mechanisms
such
as
oxidative
stress,
inflammation,
DNA
damage,
autophagy,
mitochondrial
dysfunction
morphological
changes
nephron
hepatocytes
exerts
deleterious
effect
liver
causing
hepatotoxicity.
animal
cellular
studies
that
demonstrate
AA-induced
Lastly,
article
emphasizes
underlying
protective
pharmacological
interventions
against
induced
nephrotoxicity.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 19, 2024
Abstract
Moringa
oleifera
is
one
of
the
popular
functional
foods
that
has
been
tremendously
exploited
for
synthesis
a
vast
majority
metal
nanoparticles
(NPs).
The
diverse
secondary
metabolites
present
in
this
plant
turn
it
into
green
tool
different
NPs
with
various
biological
activities.
In
review,
we
discussed
types
including
silver,
gold,
titanium
oxide,
iron
and
zinc
oxide
produced
from
extract
parts
M.
oleifera.
Different
take
role
as
reducing,
stabilizing,
capping
agent,
depending
on
source
extract,
color
solution
changes
within
NP
synthesis.
We
highlighted
polyphenols
among
major
constituents
extract.
methods
could
lead
to
formation
sizes
shapes
play
crucial
biomedical
application
were
critically
discussed.
further
debated
mechanism
interaction
cells,
their
clearance
body.
made
anticancer,
antimicrobial,
wound
healing,
water
treatment
agent
also
Small
show
better
antimicrobial
activity,
while
they
can
be
easily
cleared
body
through
kidney.
contrast,
large
are
taken
by
mono
nuclear
phagocyte
system
(MPS)
cells.
case
shape,
spherical
shape
penetrate
bacteria,
stronger
antibacterial
activity
compared
other
shapes.
Finally,
review
aims
correlate
key
characteristics
such
size
interactions
cells
designing
engineering
them
bio-applications
especially
therapeutic
purposes.
Graphical
Biofuels Bioproducts and Biorefining,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Abstract
The
Moringa
oleifera
oil
tree
is
commonly
known
as
the
‘tree
of
life’
or
‘miracle
tree’
owing
to
its
multiple
benefits
for
humans.
different
parts
that
make
up
this
(leaves,
seeds
and
bark)
have
been
used
treat
various
ailments,
diseases
wounds.
However,
in
recent
years
being
by
scientific
community
obtain
high
value‐added
products
bioenergy
sector.
This
review
aims
compile
research
works
existing
literature,
which
aim
at
development
application
added
value
These
include
extraction
lipids
present
production
biodiesel,
activated
carbon
manufacture
supercapacitors
electrodes
fuel
cells,
bio‐coagulant
water
purification,
second‐generation
bioethanol
metallic
nanoparticles.
Furthermore,
leaves
are
green
heterogeneous
catalysts
well
explored
bio‐hydrogen
production.
main
physicochemical
properties
compounds
each
mentioned
along
with
variables
these
results
obtained.
It
expected
article
will
contribute
strengthening
carrying
out
new
work
focused
on
use
M.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(9), P. e30627 - e30627
Published: May 1, 2024
Hepatotoxin
carbon
tetrachloride
(CCl4)
causes
liver
injury.
This
research
aims
to
create
ZnO-NPs
using
green
synthesis
from
Moringa
oleifera
(MO)
leaves
aqueous
extract,
and
chemically
prepared
confirming
the
by
specialized
equipment
analysis.
The
sizes
formed
of
were
80
55
nm
for
chemical
methods,
respectively.
In
addition,
study
their
ability
protect
Wistar
Albino
male
rats
against
oxidative
stress
exposed
tetrachloride.
MO
leaf
synthesized
ZnO-NPs,
at
100
200
mg/kg
BW
per
day
investigated
hepatoprotective
effects
on
enzyme
biomarkers,
renal
antioxidant
enzymes,
lipid
peroxidation,
hematological
parameters,
histopathological
changes.
Compared
control
group,
all
kidney
indicators
considerably
elevated
after
CCl4
injection.
However,
activity
enzymes
in
was
significantly
reduced
These
outcomes
indicate
that
greenly
can
restore
normal
function
activity,
as
well
enzymes.
highest
impact
enhancing
effect
recorded
received
ZnO-NPs.
increased
drug
delivery
mechanism
resulted
a
higher
protective
than
extract.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 172 - 172
Published: Jan. 28, 2025
Background/Objectives:
Bee
venom
(BV),
as
a
natural
product,
is
one
of
the
foundations
pharmaceutical
industry,
through
which
many
diseases,
including
serious
ones,
can
be
effectively
treated.
The
BV
nanofilm
an
effective
antidote
delivered
into
human
body
to
target
affected
area
and
address
issue
without
major
side
effects.
In
this
study,
we
investigated
intriguing
therapeutic
effects
apitoxin
(bee
venom)
used
in
isolation,
combined
with
powerful
properties
zinc
oxide
nanoparticles.
Methods
Results:
was
evaluated
using
Fourier
transform
infrared
(FTIR)
spectroscopy
X-ray
diffraction
(XRD).
extract
analyzed
mass
spectrometry
(MS),
identified
84
active
components
present
at
varying
concentrations.
treated
both
polyvinyl
alcohol
(PVA)
nanoparticles
(ZNPs)
increase
intensity
OH
CH2
groups
enhance
dispersion
C=O.
has
demonstrated
anti-type
2
diabetes
activity
by
inhibiting
α-amylase
α-glucosidase,
are
starch-degrading
enzymes.
mixture
BV,
PVA,
ZNPs,
exhibited
highest
antidiabetic
IC50
values
30.33
μg/mL
5.55
for
inhibition
compared
51.69
µg/mL
7.30
respectively.
also
showed
higher
anti-inflammatory
red
blood
cell
(RBC)
hemolysis,
16.99
comparison
72.99
alone.
broad-spectrum
antimicrobial
activity,
targeting
Gram-positive
(Staphylococcus
aureus
ATCC
6538
Bacillus
subtilis
6633)
Gram-negative
bacteria
(Salmonella
typhi
6539,
Escherichia
coli
8739).
Furthermore,
increased
antioxidant
recorded
1,1-diphenyl-2-picrylhydrazyl
(DPPH)
scavenging
effect
4.26
19.43
found
more
toxic
liver
tissue
(HepG2
line)
than
nanofilm,
18.5
±
0.08
52.27
0.7
μg/mL,
displayed
toxicity
(2.3%)
97.7%
viability
250
0.09%
99.9%
same
concentration.
Conclusions:
emerges
promising
alternative
medicine,
offering
innovative
solution
treating
various
diseases
its
high
concentration
therapeutically
compounds
effortless
delivery.
