Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects DOI
Yuan Liang, Zhuolin Li, Jie Zhang

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 21(2)

Published: Dec. 22, 2023

Over the past decades, synthetic glucocorticoids (GCs) have been widely used in clinical practice and animal husbandry. Given health hazard of these toxic residues food, it is necessary to explore detailed interaction mechanisms typical GCs their main target glucocorticoid receptor (GR). Hence, this work compared GR binding agonist activities GCs. Fluorescence polarization assay showed that were potent ligands GR. Their affinities order methylprednisolone>betamethasone≈prednisolone>dexamethasone, with IC

Language: Английский

Insights into interaction of triazine herbicides with three kinds of different alkyl groups (simetryne, ametryn and terbutryn) with human serum albumin via multi-spectral analysis DOI
Ying Yang,

Wenhui Han,

Honglu Zhang

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 201, P. 105895 - 105895

Published: April 2, 2024

Language: Английский

Citations

4
Insights into the Interactions of two perfluorocarboxylic acids with Human Serum Albumin: Thermodynamics, Spectroscopy, and Molecular Simulations DOI

Mingguo Peng,

Xichen Wang, Yao Wu

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142172 - 142172

Published: March 1, 2025

Language: Английский

Citations

0
Exploring the interaction of hesperetin-mediated green synthesised gold and silver nanoparticles with human serum albumin: A comparative analysis DOI
Aparna Raj,

L. Vidya,

T.N. Vipina Vinod

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126488 - 126488

Published: Nov. 1, 2024

Language: Английский

Citations

3
Current analytical methods and applications used in the insight of serum proteins interactions with various food additives, pesticides, and contaminants DOI Creative Commons
Cem Erkmen, Md. Zahirul Kabır

Published: May 24, 2024

In recent years, many societies have expressed increasing apprehension regarding the potential negative impacts of food additives, pesticides, and environmental contaminants on human health. Environmental or occupational exposure to these compounds can cause significant adverse effects health by causing temporary permanent changes in immune system. There is supporting evidence linking pesticides/food ingredients/contaminants-induced alterations prevalence diseases associated with responses. Hence, it essential comprehensively understand key mechanisms contributing dysregulation induced substances, including direct immunotoxicity, endocrine disruption, antigenicity. The impact ingredients body ranges from mild severe, depending their affinity for blood components. These form complexes serum proteins, influencing metabolism, transport, absorption, overall toxicity. Numerous studies literature explored interactions between proteins various molecules, drugs, dyes. investigations employed a range techniques, spectroscopy, electrochemical chromatographic methods as well molecular modeling dynamics simulations analyses. This review, spanning 2020 present, has been investigate binding characteristics, mechanisms, attributes different using techniques such steady-state fluorescence, circular dichroism ultra-violet spectroscopies, computational docking methods. review provides insights into compounds’ positions affinities possible through detailed research studies.

Language: Английский

Citations

2
Typical endocrine disruptors diethylstilbestrol and its analogues non-covalently bind to human serum albumin DOI

Y. Ao,

Y. Liu,

Yuan Chen

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1311, P. 138409 - 138409

Published: April 19, 2024

Language: Английский

Citations

1
Degradation Kinetics and Mechanism of β-Cypermethrin and 3-Phenoxybenzoic Acid by Lysinibacillus pakistanensis VF-2 in Soil Remediation DOI
Xuan Yu,

Hu Zhou,

Jie Tang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Pyrethroid pesticide residues have detrimental effects on soil ecology and crop growth during insecticidal operations in agriculture. In this study, a novel strain

Language: Английский

Citations

0
Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects DOI
Yuan Liang, Zhuolin Li, Jie Zhang

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 21(2)

Published: Dec. 22, 2023

Over the past decades, synthetic glucocorticoids (GCs) have been widely used in clinical practice and animal husbandry. Given health hazard of these toxic residues food, it is necessary to explore detailed interaction mechanisms typical GCs their main target glucocorticoid receptor (GR). Hence, this work compared GR binding agonist activities GCs. Fluorescence polarization assay showed that were potent ligands GR. Their affinities order methylprednisolone>betamethasone≈prednisolone>dexamethasone, with IC

Language: Английский

Citations

1