Foxa2 attenuates steatosis and inhibits the NF-κB/IKK signaling pathway in nonalcoholic fatty liver disease DOI Creative Commons
Li Yang, Qiang Ma, Jiayu Chen

et al.

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e16466 - e16466

Published: Dec. 7, 2023

Objective Forkhead box a2 (Foxa2) is proven to be an insulin-sensitive transcriptional regulator and affects hepatic steatosis. This study aims investigate the mechanism by which Foxa2 nonalcoholic fatty liver disease (NAFLD). Methods Animal cellular models of NAFLD were constructed using high-fat diet (HFD) feeding oleic acid (OA) stimulation, respectively. mice received tail vein injections either overexpressing negative control (oe-NC) or (oe-Foxa2) for four weeks. HepG2 cells transfected with oe-NC oe-Foxa2 48 h before OA stimulation. Histological changes lipid accumulation assessed hematoxylin-eosin staining oil red O staining, Expression Foxa2, NF-κB/IKK pathway proteins, synthesis β-oxidation protein in HFD OA-induced was detected western blot. Results expression downregulated cells. overexpression attenuated injury, reduced levels aspartate aminotransferase, alanine total cholesterol, triglyceride Moreover, decreased proteins increased tissues. Furthermore, p-NF-κB/NF-κB p-IKK/IKK Additionally, lipopolysaccharide (NF-κB/IKK activator) administration reversed downregulation upregulation protein. Conclusion NAFLD. ameliorated steatosis inhibited activation signaling pathway.

Language: Английский

Polysaccharide from Panax japonicus C.A. Mey prevents non-alcoholic fatty liver disease development based on regulating liver metabolism and gut microbiota in mice DOI
Yi Wu, Wen Yin,

Ping Hao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129430 - 129430

Published: Jan. 18, 2024

Language: Английский

Citations

11
Effect of Tetrastigma hemsleyanum leaves and Extract supplementation on liver metabolomics and the gut microbiota in alcohol-induced liver injury DOI

Kexin Tao,

Han Peng, Xin Bi

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 58, P. 103617 - 103617

Published: Jan. 20, 2024

Language: Английский

Citations

7
Exploring the mechanism of SLXG for treating nonalcoholic fatty liver disease based on network pharmacology and molecular docking DOI Creative Commons
Yang Wang, Jiaxing Wang, Zitong Chen

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(6), P. e40255 - e40255

Published: Feb. 7, 2025

Background: The Shugan Lidan Decoction and Chaihu formula are traditional Chinese medicine formulas for treating liver diseases, with a history of over 1000 years. By comprehensively improving 2 medicinal formulas, Xiaoshi Granules (SLXG) has been developed the treatment nonalcoholic fatty disease (NAFLD) other liver-related metabolic diseases. Methods: First, effective active ingredients targets SLXG were determined using Traditional Medicine Systems Pharmacology Database Analysis Platform database. NAFLD identified GeneCards, OMIM, CTD databases, intersection decoction was obtained. then subjected to protein–protein interaction network analysis, Kyoto encyclopedia genes genomes (KEGG) enrichment gene ontology analysis. KEGG analysis revealed pathway. Molecular docking performed validate binding between crucial enriched in this pathway corresponding SLXG. Results: A total 219 related from 239 non-duplicated drug obtained 24 target both drug- disease-related 6 results showed that 13 gene–active ingredient bindings had energy less than −6.5. Conclusion: use pharmacology molecular technology mechanism action treatment, thus laying theoretical foundation clinical application therapy.

Language: Английский

Citations

0
SUSTAINABLE AND CONTEMPORARY APPROACHES TO EXPLORE THE NUTRITIONAL AND PROCESSING PERSPECTIVES OF BUCKWHEAT: CURRENT EVIDENCE AND PROSPECTS DOI

Zunaira Basharat,

Tabussam Tufail, Feng Shao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106312 - 106312

Published: March 1, 2025

Language: Английский

Citations

0
Effect and mechanism of polysaccharide from Crataegus pinnatifida on nonalcoholic fatty liver disease DOI
Haiyan Fan,

Meng Yan,

Yongshuai Jing

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106876 - 106876

Published: May 10, 2025

Language: Английский

Citations

0
Structure characterization and cryoprotective activity of an exopolysaccharide from Pseudoalteromonas sp. LP6-12-2 DOI
Q.P. Kong, Dezhi Wang, Bailin Cong

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 57, P. 103557 - 103557

Published: Jan. 1, 2024

Language: Английский

Citations

2
New insights into the hepato-protective effects of ferulic acid based on transcriptomic and metabolomic profiling DOI Creative Commons
Lu Liu, Yuanyuan Sun, Haixia Cui

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106554 - 106554

Published: Nov. 1, 2024

Language: Английский

Citations

0
Foxa2 attenuates steatosis and inhibits the NF-κB/IKK signaling pathway in nonalcoholic fatty liver disease DOI Creative Commons
Li Yang, Qiang Ma, Jiayu Chen

et al.

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e16466 - e16466

Published: Dec. 7, 2023

Objective Forkhead box a2 (Foxa2) is proven to be an insulin-sensitive transcriptional regulator and affects hepatic steatosis. This study aims investigate the mechanism by which Foxa2 nonalcoholic fatty liver disease (NAFLD). Methods Animal cellular models of NAFLD were constructed using high-fat diet (HFD) feeding oleic acid (OA) stimulation, respectively. mice received tail vein injections either overexpressing negative control (oe-NC) or (oe-Foxa2) for four weeks. HepG2 cells transfected with oe-NC oe-Foxa2 48 h before OA stimulation. Histological changes lipid accumulation assessed hematoxylin-eosin staining oil red O staining, Expression Foxa2, NF-κB/IKK pathway proteins, synthesis β-oxidation protein in HFD OA-induced was detected western blot. Results expression downregulated cells. overexpression attenuated injury, reduced levels aspartate aminotransferase, alanine total cholesterol, triglyceride Moreover, decreased proteins increased tissues. Furthermore, p-NF-κB/NF-κB p-IKK/IKK Additionally, lipopolysaccharide (NF-κB/IKK activator) administration reversed downregulation upregulation protein. Conclusion NAFLD. ameliorated steatosis inhibited activation signaling pathway.

Language: Английский

Citations

0