Diallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(10)

Published: Oct. 23, 2024

Background: Heavy metals can cause serious health problems that affect different organs. Cadmium (Cd) is an environmental contaminant known for its toxicological consequences on Hepatotoxicity a effect of exposure to Cd with oxidative stress (OS) and inflammation playing central role. Diallyl disulfide (DADS), organo-sulfur compound found in garlic, cytoprotective antioxidant effects. In this study, the DADS Cd-induced inflammation, liver injury was investigated. Methods: supplemented 14 days via oral gavage, single intraperitoneal dose (1.2 mg/kg body weight) administered rats day 7. Blood samples were collected at end experiment analyses. Results: administration resulted remarkable hepatic dysfunction, degenerative changes, necrosis, infiltration inflammatory cells, collagen deposition other histopathological alterations. increased malondialdehyde (MDA) nitric oxide (NO) (p < 0.001), upregulated toll-like receptor (TLR)-4, nuclear factor-kappaB (NF-κB), pro-inflammatory mediators, caspase-3 0.001) whereas decreased glutathione (GSH) enzymes 0.001). downregulated peroxisome proliferator activated gamma (PPARγ), transcription factor involved OS suppression ameliorated tissue alterations, attenuated apoptosis, suppressed TLR-4/NF-κB signaling, enhanced antioxidants. addition, PPARγ Cd-administered rats. Conclusions: effective against hepatotoxicity beneficial effects are linked apoptosis upregulation PPARγ. could be valuable protect individuals risk exposure, pending further studies elucidate underlying mechanism(s).

Language: Английский

Diallyl disulfide prevents cadmium-induced testicular injury by attenuating oxidative stress, apoptosis, and TLR-4/NF-κB and JAK1/STAT3 signaling and upregulating SIRT1 in rats

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127560 - 127560

Published: Nov. 12, 2024

Language: Английский

Perindopril Dampens Cd-induced Nephrotoxicity by Suppressing Inflammatory Burden, Ang II/Ang 1–7, and Apoptosis Signaling Pathways

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(7), P. 3193 - 3203

Published: Oct. 17, 2023

Language: Английский